Retrospective evaluation of 211 patients with maxillofacial reconstruction using parietal bone graft for implants insertion

Depeyre, Arnaud; Touzet-Roumazeille, Sandrine; Lauwers, Ludovic; Raoul, G.; Ferri, Joël

doi:10.1016/j.jcms.2016.06.034

Cited by 20 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, 41 of these studies were excluded after full‐text reading, as they did not fulfill all criteria. Reasons for exclusion can be seen in Table . A PRISMA 2009 flow diagram of the study selection can be seen in Figure .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Long term follow‐up of titanium implants installed in block‐grafted areas: A systematic review

Fuglsig

Thorn

Ingerslev

et al. 2018

Clin Implant Dent Rel Res

View full text Add to dashboard Cite

Background An enduring clinical question concerns the outcome (ie, success) of implants placed in areas grafted with block‐grafts. Objective To undertake a systematic review of the literature on the long term results (≥5 years) of implants placed in maxillofacial areas grafted with any type of osseous block‐grafts in two‐stage surgeries. Further, the review addresses how available success criteria were used within the studies. Materials and Methods The MEDLINE (PubMed) and EMBASE bibliographic databases were searched up to March 2017 for studies evaluating the long term results of implants placed in grafted areas. The search strategy was restricted to English language publications using combined terms which referred to the treatment method (implants placed in areas grafted with bone blocks), and follow‐up characteristics (≥5 years and assessment of at least one parameter related to implant success criteria). To qualify for inclusion, studies should present outcome measurements indicating the success (or at least the survival) of the implants. Results The search strategy yielded 17 studies, which were included in this systematic review. These studies presented survival rates ranging from 88.7% (after 15 years follow‐up) to 98.7% (after 5 years follow‐up). Five studies presented data based on predefined success criteria with success rates ranging from 86.8% to 100%. In these studies, the term “success” was often not properly defined. Conclusion The long term survival (≥5 years) of implants placed into block‐grafted areas in two‐stage surgeries was not lower than 75%, while success rates ranged from 86.8% to 100%. Although it was possible to identify published success criteria for implant follow‐up, there is no broad consensus on how to report implant success in a consistent manner.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Depeyre et al 33 Authors did not recommend to use available long-term data due to major patient drop-out…”

Section: Implant Success and Osseointegration Were Assessed By Means mentioning

confidence: 99%

Long term follow‐up of titanium implants installed in block‐grafted areas: A systematic review

Fuglsig

Thorn

Ingerslev

et al. 2018

Clin Implant Dent Rel Res

View full text Add to dashboard Cite

show abstract

“…>10,000 cleft palate repairs) [13,14], but current clinical materials have significant shortcomings. Autologous or allogenic bone remains a gold standard [15,16], but are limited by access to autologous bone [17,18], donor site morbidity, surgical complications after cancellous autografts or cadaveric allografts (10-40%) [19,20], and difficulty fitting irregular defects [15,21], as well as inconsistent repair [21,22]. Alloplastic materials are plagued by complications such as extrusion, high cost, and high infection rates (5-12x more complications than autologous transplant) [2,3,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold

et al. 2021

View full text Add to dashboard Cite

Regenerative repair of craniomaxillofacial bone injuries is challenging due to both the large size and irregular shape of many defects. Mineralized collagen scaffolds have previously been shown to be a promising biomaterial implant to accelerate craniofacial bone regeneration in vivo. Here we describe inclusion of a 3D-printed polymer or ceramic-based mesh into a mineralized collagen scaffold to improve mechanical and biological activity. Mineralized collagen scaffolds were reinforced with 3D-printed Fluffy-PLG (ultraporous polylactide-co-glycolide copolymer) or Hyperelastic Bone (90wt% calcium phosphate in PLG) meshes. We show degradation byproducts and acidic release from the printed structures have limited negative impact on the viability of mesenchymal stem cells. Further, inclusion of a mesh formed from Hyperelastic Bone generates a reinforced composite with significantly improved mechanical performance (elastic modulus, push-out strength). Composites formed from the mineralized collagen scaffold and either Hyperelastic Bone or Fluffy-PLG reinforcement both supported human bone-marrow derived mesenchymal stem cell osteogenesis and new bone formation. Strikingly, composites reinforced with Hyperelastic Bone mesh elicited significantly increased secretion of osteoprotegerin, a soluble glycoprotein and endogenous inhibitor of osteoclast activity. These results suggest that architectured meshes can be integrated into collagen scaffolds to boost mechanical performance and actively instruct cell processes that aid osteogenicity; specifically, secretion of a factor crucial to inhibiting osteoclast-mediated bone resorption. Future work will focus on further adapting the polymer mesh architecture to confer improved shape-fitting capacity as well as to investigate the role of polymer reinforcement on MSC-osteoclast interactions as a means to increase regenerative potential.

show abstract

“…Current methods of repair involve the use of autografts or allografts, bone from the patient or a donor, respectively. Autografts are limited by the amount of bone able to be removed and possible morbidity at the site of removal [3,4]. Allografts are limited by the processing method, with cellular materials removed before implantation to avoid disease transmission, which can also remove beneficial components that aid in repair [5].…”

Section: Introductionmentioning

confidence: 99%

Repair of critical-size porcine craniofacial bone defects using a collagen-polycaprolactone composite biomaterial

Dewey

Milner

Weisgerber

et al. 2021

Preprint

View full text Add to dashboard Cite

Regenerative medicine approaches for massive craniomaxillofacial bone defects face challenges associated with the scale of missing bone, the need for rapid graft-defect integration, and challenges related to inflammation and infection. Mineralized collagen scaffolds have been shown to promote mesenchymal stem cell osteogenesis due to their porous nature and material properties, but are mechanically weak, limiting surgical practicality. Previously, these scaffolds were combined with 3D-printed polycaprolactone mesh to form a scaffold-mesh composite to increase strength and promote bone formation in sub-critical sized porcine ramus defects. Here, we compare the performance of mineralized collagen-polycaprolactone composites to the polycaprolactone mesh in a critical-sized porcine ramus defect model. While there were no differences in overall healing response between groups, our data demonstrated broadly variable metrics of healing regarding new bone infiltration and fibrous tissue formation. Abscesses were present surrounding some implants and polycaprolactone polymer was still present after 9-10 months of implantation. Overall, while there was limited successful healing, with 2 of 22 implants showed substantial levels of bone regeneration, and others demonstrating some form of new bone formation, the results suggest targeted improvements to improve repair of large animal models to more accurately represent craniomaxillofacial bone healing. Notably, strategies to increase osteogenesis throughout the implant, modulate the immune system to support repair, and employ shape-fitting tactics to avoid implant micromotion and resultant fibrosis. Improvements to the mineralized collagen scaffolds involve changes in pore size and shape to increase cell migration and osteogenesis and inclusion or delivery of factors to aid vascular ingrowth and bone regeneration.

show abstract

Retrospective evaluation of 211 patients with maxillofacial reconstruction using parietal bone graft for implants insertion

Cited by 20 publications

References 41 publications

Long term follow‐up of titanium implants installed in block‐grafted areas: A systematic review

Long term follow‐up of titanium implants installed in block‐grafted areas: A systematic review

Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold

Repair of critical-size porcine craniofacial bone defects using a collagen-polycaprolactone composite biomaterial

Contact Info

Product

Resources

About