Retrospective Evaluation of 100 Patients with Sarcoidosis in Gazi University, Turkey

Aykan, Filiz Sadi; Türktaş, Haluk; Köktürk, Nurdan; Akten, Serpil

doi:10.5152/ttd.2014.4116

Cited by 4 publications

(9 citation statements)

References 26 publications

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“…ACCESS çalışmasında kadın/erkek oranı 1.77, ülkemizden yapılan çalışmalarda 3.1, 2.08 iken, çalışmamızda bu oran 4.3 olarak daha yük-sek bulunmuştur 1,6,7 . Olgularımızın ortalama yaşı 51 olarak, literatürdeki değerlerin üzerinde bulundu 7,8 . Bu yükseklik yaşlı hastalarda malignite şüphesi ile daha fazla PET/BT çekilmesi ile açıklanabilir.…”

Section: Discussionunclassified

“…Bu yükseklik yaşlı hastalarda malignite şüphesi ile daha fazla PET/BT çekilmesi ile açıklanabilir. Sigara içimi ve sarkoidoz arasında negatif korelasyon olduğu ve sarkoidoz hastalarında sigara içme oranlarının %8-%20 olduğu bildirilmiştir 1,7,8 . Çalışmamızda, sigara öyküsü %25 hastada mevcut olup, daha önce bildirilmiş oranlara göre kısmen yüksektir.…”

Section: Discussionunclassified

“…Sarkoidozda en sık görülen semptomlar öksürük, nefes darlığı ve göğüs ağrısıdır 1,7 . Çalışmamızdaki olgular da en sık öksürük (%28) ve göğüs ağrısı (%28) yakınmasıyla başvurmuştur.…”

Section: Discussionunclassified

“…Sarkoidoz hastalarında yüksek ACE düzeyleri %56-%61 oranında bildirilmiştir 1,7 . Sarkoid granülomlar tarafından üretilen ACE'nin aktivite tayini ve tedavi planlamada kullanılmış, ancak kronik sarkoidozlu hastaların yalnızca %60'ında ACE normalin üstünde saptanmış ve hastalığın ciddiyeti, progresyonu, ve tedavi yanıtı ile ilişkili olmadığı gösterilmiştir 9,10 .…”

Section: Discussionunclassified

“…Toraks tomografisinde tüm olgularda mediastinal lenfadenopati (%100), 30 olguda da pulmoner nodüler görünüm (%56) saptandı. Ülkemizden yapılan diğer sarkoidoz çalışmalarında da hastaların %35-%44 oranında evre 1 ve %40-43 oranında evre 2 olduğu bildirilmiştir 1,7,8 . Akciğer grafisi pulmoner sarkoidozun değerlendirmesinde ilk başvurulacak görüntüleme yöntemidir, ancak radyolojik skorlama, inflamatuar aktiviteyi belirlemede yetersiz kalır 11 .…”

Section: Discussionunclassified

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PET/CT findings in sarcoidosis: Analysis of 53 cases

Duman¹,

Bekir²,

Altunbey³

et al. 2017

MMJ

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Section: Discussionunclassified

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PET/CT findings in sarcoidosis: Analysis of 53 cases

Duman¹,

Bekir²,

Altunbey³

et al. 2017

MMJ

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Ekstrapulmoner sarkoidoz

Aksoy¹

2018

South Clin Ist Euras

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In cases of pulmonary sarcoidosis, extrapulmonary involvement is not uncommon. The skin, eyes, and lymph nodes are the most common sites of extrapulmonary involvement, and multiple organs may be involved at the same time. In this study, patients with extrapulmonary sarcoidosis were investigated in terms of the localization of involvement. Methods: Patients diagnosed with sarcoidosis between 1994 and 2015 were evaluated retrospectively. Demographic characteristics, symptoms, organ involvement, diagnostic methods, and the length of time between the diagnosis of sarcoidosis and additional organ involvement were recorded. The patients were consulted to the departments of dermatology, ophthalmology, and cardiology, and a chest X-ray, high-resolution computed tomography, and abdominal ultrasound examinations were performed. Results: Extrapulmonary involvement was detected in 144 of a total of 337 sarcoidosis patients. In 92% of those patients with extrapulmonary involvement, there was accompanying pulmonary involvement. Women made up 75% of the group, and the mean age was 43 years. The most commonly detected extrapulmonary involvement was of the skin (n=41), followed by erythema nodosum (n=37), and involvement of the liver (n=24), lymph nodes (n=20), spleen (n=18), and salivary/parotid gland (n=15). The most frequent diagnostic method used was mediastinoscopy (n=41), followed by a skin biopsy (n=23), and a transbronchial lung biopsy (n=19). Of the 26 (18%) patients who had multiple-organ involvement, 2 were diagnosed as stage 0, 14 were stage 1, 9 were stage 2, and 1 was stage 3. The mean length of time before a diagnosis of extrapulmonary involvement was 24 days. Conclusion: If there is extrapulmonary involvement in a case of sarcoidosis, it should be kept in mind that more than 1 organ system may be involved and the relevant additional tests may be required.

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Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis

Çelik¹,

BULUT

2022

Acta Medica Alanya

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Aim: The natural course of sarcoidosis is heterogeneous. There is no clear marker that can predict the course of this disease and its characteristics over months/years. We aimed to analyze our patients' data to identify a prediction parameter at admission.Methods: The patients with sarcoidosis and followed-up between 01/01/2015 and 31/12/2020 comprised the study group. The patients were staged by a Scadding staging system. Improvement or deterioration in at least two of the clinical-laboratory-radiological parameters indicates regression, stable disease, progression, or relapse of sarcoidosis.Results: The study group comprised 4 cases (6.9%) defined as stage 0; 15 cases (25.86%) as stage 1; 39 cases (67.24%) were defined as stage 2. The mean age at diagnosis was 40.84±13.56 in stage 0 + stage 1 group, while it was 48.05±13.36 in the stage 2 group (p=0.06). 74.1% of the cases were women. The female/male ratio was found at 2.86. 57 out of 58 cases had a pathological diagnosis (EBUS TBNA). While PFTs values and DLCO were significantly lower at advanced stages but the same statistical significance was not identified between these values and the clinical course of the disease. As a result of the multivariate analysis, it was observed that only the presence of chest pain at admission affected the progression of the disease in the follow-up period.Conclusion: Sarcoidosis is a multi-systemic disease and there is no clear finding for predicting the poor prognosis of the disease. We conclude that chest pain symptom at admission is valuable predictive finding and can be used as a clue for the progression at follow-up.

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Retrospective Evaluation of 100 Patients with Sarcoidosis in Gazi University, Turkey

Cited by 4 publications

References 26 publications

PET/CT findings in sarcoidosis: Analysis of 53 cases

PET/CT findings in sarcoidosis: Analysis of 53 cases

Ekstrapulmoner sarkoidoz

Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis

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