Retrospective diagnosis of sickle cell-hemoglobin C disease and parvovirus infection by molecular DNA analysis of postmortem tissue

Goldstein, Lisa; Strenger, Rochelle; King, Thomas C.; Le, Stacy Comfort; Rogers, Beverly Barton

doi:10.1016/0046-8177(95)90304-6

Cited by 5 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirty-nine (34.5%) children seroconverted during the course of this study but did not have documented exacerbation of anemia with severe reticulocytopenia: SCD-SS (22), SCD-S␤ 0 thalassemia (1), SCD-SC (12), and SCD-S␤ ϩ thalassemia (4). Two of these children with SCD-SS were on hydroxyurea therapy, and 6 were on chronic transfusion therapy.…”

Section: Acute Infections Without Exacerbation Of Anemiamentioning

confidence: 86%

“…These complications or untreated severe anemia could result in chronic medical conditions or death. 1,7,12,13 Since HPV B19 was found to be the cause of TRCA in 1981, 14,15 clinicians have been eagerly awaiting the development of a vaccine or other prevention strategies that would diminish the morbidity and mortality of these infections. 16 Accurate epidemiologic data on the frequency of HPV B19 infection and its associated complications in children with SCD are essential for assessing the potential effect of viral prevention programs in this patient population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of human parvovirus B19 in children with sickle cell disease

Smith‐Whitley

Zhao

Hodinka

et al. 2004

Blood

134

View full text Add to dashboard Cite

Human parvovirus (HPV) B19 causes significant morbidity and mortality in children with sickle cell disease (SCD), but little data are published about the epidemiology of HPV B19 infection and its associated complications in this patient population. In this study, prevalence and incidence rates of HPV B19 were determined in 633 patients with SCD followed at The Children's Hospital of Philadelphia between November 1996 and December 2001. Thirty percent (30%) were HPV B19 immunoglobulin G (IgG) positive at first testing, and the 70% without evidence of past HPV B19 infection were tested annually. One hundred ten patients developed evidence of HPV B19 infection for an incidence rate of 11.3 per 100 patient years. Sixty-eight episodes of HPV B19-induced transient red cell aplasia occurred with the following clinical events: fever (89.7%), pain (61.8%), acute splenic sequestration (19.1%), and acute chest syndrome (11.8%). Pain, fever, and acute splenic sequestration were more frequent events with acute HPV B19 infections compared with acute events in uninfected patients. The results of this epidemiologic study, the largest and most comprehensive to date, justify the development of HPV B19 prevention strategies to diminish the frequent and often severe complications associated with HPV B19 infections in patients with SCD.

show abstract

Section: Acute Infections Without Exacerbation Of Anemiamentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Epidemiology of human parvovirus B19 in children with sickle cell disease

Smith‐Whitley

Zhao

Hodinka

et al. 2004

Blood

134

View full text Add to dashboard Cite

show abstract

“…Only in the latter setting is a bone marrow biopsy likely to be performed. Only rare sickle cell disease patients develop bone marrow necrosis on nondirected biopsies; increasing the likelihood of necrosis includes the presence concomitant parvovirus infection . Bone marrow necrosis appears to enrich in sickle cell variants such as Hgb SC disease or Hgb S/ beta + thalassemia.…”

Section: Differential Diagnosis Of Underlying Etiologymentioning

confidence: 99%

How I investigate bone marrow necrosis

Deucher

Wool

2019

Int J Lab Hematology

View full text Add to dashboard Cite

Hematopathologists encounter bone marrow biopsy specimens with marrow necrosis relatively infrequently; when necrosis is seen, determining the clinical significance can be challenging. While bone marrow necrosis is not uncommon in site‐directed biopsy specimens or autopsy material, substantial necrosis is much less common in nondirected bone marrow biopsy specimens. Retrospective review showed the prevalence of bone marrow necrosis to vary between 0.3% and 2% antemortem, depending on the patient population. Numerous causes of bone marrow necrosis have been identified, including malignancy, radiation/chemotherapy, medication, infection, autoimmune disease, disseminated intravascular coagulation, antiphospholipid syndrome and other thrombotic disorders, granulocyte‐colony stimulating factor (G‐CSF) exposure, and hemoglobinopathies. Clinical findings associated with bone marrow necrosis include bone pain and fever, cytopenias, elevated LDH and ferritin, and leukoerythroblastosis. Rarely, such as in fat embolization syndrome (FES), bone marrow necrosis can be associated with thrombotic microangiopathy, neurologic dysfunction, and multiorgan failure. A thorough review of the patient's clinical record (including medical history, clinical presentation, and other laboratory findings), a thorough morphologic review of the bone marrow with appropriate ancillary stains, and an appreciation of the causes of bone marrow necrosis in different patient populations are required to determine the underlying cause of bone marrow necrosis. The purpose of this review is to present a strategy for evaluation of bone marrow necrosis found in an antemortem biopsy specimen.

show abstract

“…The cause for the splenic sequestration was unknown, although one could postulate that anemia with resulting hypoxia predisposed the patients to sickling, followed by obstruction of the splenic sinusoids by the sickled cells. Acute chest syndrome and bone marrow necrosis have been described in patients with acute parvovirus B19 infection [45][46][47]. Bone marrow necrosis with pulmonary emboli resulted in death in a patient with hemoglobin sickle cell disease [46] and a patient with sickle/betaϩ thalassemia [47].…”

Section: Parvovirus B19 In Patients With Underlying Disease Inheritedmentioning

confidence: 99%

“…Acute chest syndrome and bone marrow necrosis have been described in patients with acute parvovirus B19 infection [45][46][47]. Bone marrow necrosis with pulmonary emboli resulted in death in a patient with hemoglobin sickle cell disease [46] and a patient with sickle/betaϩ thalassemia [47]. Because of the concomitant presentation of bone marrow emboli and acute chest syndrome, Lowenthal et al postulated that the acute chest syndrome may be a clinical reflection of bone marrow emboli to the lungs [45].…”

Section: Parvovirus B19 In Patients With Underlying Disease Inheritedmentioning

confidence: 99%