Retrospective cohort study of laparoscopic ICG-Guided Lymphadenectomy in gastric cancer from a Western country center

Efficacy of indocyanine green fluorescence imaging-guided lymphadenectomy in radical gastrectomy for gastric cancer: A systematic review and meta-analysis

“…( 19 ) reported that ICG fluorescence imaging-guided lymphadenectomy could reduce the tumor recurrence rate after surgery, with the recurrence rate 8.1% and 17.0% in the ICG and control groups, respectively. And another two studies also got the similar results ( 21 , 22 ). However, Wei M et al.…”

“…In terms of oncological outcomes, four studies ( 19 , 21 , 22 , 28 ) reported the overall recurrence rate and the pooled analysis showed that the use of ICG could reduce the overall recurrence rate (OR = 0.50; 95% CI 0.28-0.89; P = 0.02) ( Figure 6A ). However, in terms of postoperative overall survival, two studies ( 19 , 28 ) reported the 2-year overall survival rate but there was no difference between the ICG and control groups (OR = 1.25; 95% CI 0.72-2.18; P = 0.43) ( Figure 6B ).…”

“…A total of 612 studies were identified, and 17 studies including 15 retrospective studies and 2 randomized controlled trials (RCTs) were ultimately included in this meta-analysis (13,14,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The details of the selection procedures are shown to be in line with the PRISMA flowchart (Figure 1).…”

“…The primary outcome of this study was to assess the efficacy of lymphadenectomy by using ICG fluorescence imaging. Ultimately, 17 studies (2274 patients) (13,14,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) reporting this outcome were included in our meta-analysis. The pooled analysis revealed that the number of retrieved LNs in the ICG group was significantly more than that in the control group (MD = 7.41, 95% CI = 5.44 to 9.37, P < 0.00001) (Figure 4A), but there is no significant difference in terms of metastatic LNs between the ICG and control groups (MD = -0.05, 95% CI = -0.25 to 0.16, P = 0.65) (Figure 4B).…”

Securing Resection Margin Using Indocyanine Green Diffusion Range on Gastric Wall during NIR Fluorescence-Guided Surgery in Early Gastric Cancer Patients

“…Recently, near-infrared (NIR) fluorescence-guided surgery has been widely employed for minimally invasive gastrectomy to visualize lymphatic drainage from the primary tumor by endoscopic submucosal indocyanine green (ICG) injection around the tumor in four quadrants [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In particular, since the enlargement of metastatic lymph nodes is rare in early gastric cancer, fluorescence-guided lymphadenectomy is expected to reduce the risk of missing small, potentially metastatic lymph nodes by visualizing lymphatic structures draining from the tumor.…”