Retrospective chart review of catatonia in child and adolescent psychiatric patients

Ghaziuddin, Neera; Dhossche, Dirk M.; Marcotte, Kayla

doi:10.1111/j.1600-0447.2011.01778.x

Cited by 98 publications

(74 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A small number of patients with an ASD not only demonstrate involuntary, mechanical, and repetitive SIB, but also more classical akinetic motor signs, characteristic of catatonic states associated with mood disorders or psychosis. In fact, in recent years large population-based studies have estimated that 12-18% of autistic adolescents and young adults manifest some symptoms of catatonia (Billstedt et al, 2005;Ghaziuddin et al, 2012;Wing and Shah, 2000). Consistent with the sensitivity of catatonia to electroconvulsive therapy (ECT; Fink and Taylor, 2006), we and others have found ECT can produce life-changing results in ASD patients with extreme SIB that is unresponsive to traditional pharmacological and behavioral therapies (Wachtel and Dhossche, 2013;Consoli et al, 2013;Haq and Ghaziuddin, 2014).…”

Section: Introductionsupporting

confidence: 62%

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Chang

Berges

Chung

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

Approximately one quarter of individuals with an autism spectrum disorder (ASD) display self-injurious behavior (SIB) ranging from head banging to self-directed biting and punching. Sometimes, these behaviors are extreme and unresponsive to pharmacological and behavioral therapies. We have found electroconvulsive therapy (ECT) can produce life-changing results, with more than 90% suppression of SIB frequency. However, these patients typically require frequent maintenance ECT (mECT), as often as every 5 days, to sustain the improvement gained during the acute course. Long-term consequences of such frequent mECT started as early as childhood in some cases are unknown. Accordingly, there is a need for alternative forms of chronic stimulation for these patients. To explore the feasibility of deep brain stimulation (DBS) for intractable SIB seen in some patients with an ASD, we utilized two genetically distinct mouse models demonstrating excessive self-grooming, namely the Viaat-Mecp2 − /y and Shank3B −/− lines, and administered high-frequency stimulation (HFS) via implanted electrodes at the subthalamic nucleus (STN-HFS). We found that STN-HFS significantly suppressed excessive selfgrooming in both genetic lines. Suppression occurs both acutely when stimulation is switched on, and persists for several days after HFS is stopped. This effect was not explained by a change in locomotor activity, which was unaffected by STN-HFS. Likewise, social interaction deficits were not corrected by STN-HFS. Our data show STN-HFS suppresses excessive self-grooming in two autism-like mouse models, raising the possibility DBS might be used to treat intractable SIB associated with ASDs. Further studies are required to explore the circuitry engaged by STN-HFS, as well as other potential stimulation sites. Such studies might also yield clues about pathways, which could be modulated by non-invasive stimulatory techniques.

show abstract

Section: Introductionsupporting

confidence: 62%

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Chang

Berges

Chung

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The central symptom of catatonia is disturbance of motor activity (overall increased activity, reduced activity or mixed) and a variety of other abnormal movements (e.g. reduced eye blink rate, grimacing, sudden cessation of movements or immobility) (39).…”

Section: Discussionmentioning

confidence: 99%

Psychosis and catatonia in fragile X: Case report and literature review

Winarni

Schneider

Ghaziuddin

et al. 2015

IRDR

View full text Add to dashboard Cite

“…Wider recognition of the benefits of ECT in children and adolescents with catatonia will lead to the consideration of ECT as a viable treatment option in this age group (13).…”

Section: Case Report Discussionmentioning

confidence: 99%

Electroconvulsive therapy in a twelve-year-old boy with catatonic symptoms

et al. 2013

View full text Add to dashboard Cite

SummaryStudies Electroconvulsive therapy (ECT) is effective in the treatment of several psychiatric illnesses. Only a few studies describe the use of ECT in children and adolescents. We describe the treatment of catatonic symptoms with ECT in a twelve-year-old boy who presented with complaints of nausea, vomiting and ataxia and developed catatonic symptoms 48 hours after admission to hospital. The response to diazepam infusion was partial but recovery was complete after 12 treatments of ECT. There were no adverse effects to ECT.

show abstract

Retrospective chart review of catatonia in child and adolescent psychiatric patients

Abstract: We concluded that catatonia is under recognized and undertreated among children and adolescents receiving psychiatric treatment.

Cited by 98 publications

References 26 publications

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Psychosis and catatonia in fragile X: Case report and literature review

Electroconvulsive therapy in a twelve-year-old boy with catatonic symptoms

Contact Info

Product

Resources

About