Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation

Cebulska-Wasilewska, Antonina; Krzysiek, M.; Krajewska, G.; Stępień, Artur; Krajewski, P.

doi:10.4103/2041-9414.198906

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25,26 Large doses of radiotherapy may kill tumor cells but could also lead to mutation of tumor cells and further differentiation. 27 Molecular subgrouping has already been applied to clinical trials involving a variety of adjuvant therapy schemes, and this classic scheme is likely to be modified or supplanted by a scheme based on molecular subgroups. 28 MB is a highly malignant brain tumor with a poor prognosis in children.…”

Section: Discussionmentioning

confidence: 99%

Post-treatment maturation of medulloblastoma in children: two cases and a literature review

Zhou

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

We herein report two cases of post-treatment maturation of medulloblastoma (MB). We also conducted a literature review to summarize the clinical and pathologic features of MB maturation. From January 1992 to February 2017, 52 patients with MB underwent surgical resection followed by radiotherapy and chemotherapy. Tumor cell maturation was identified in two patients who underwent a second surgery. We conducted a systematic search of PubMed and identified six such cases. In both of our patients, the pathologic type was MB with extensive nodularity (MBEN). Both patients underwent radiotherapy and chemotherapy. The tumor differentiated to gangliocytoma in both patients. In the overall analysis that also included the six cases identified in the literature, the pathologic types were classic MB (n=1), desmoplastic/nodular MB (n=2), MBEN (n=3), and unclassified MB (n=2). MB differentiated into the following types: gangliocytoma (n=2), ganglioglioma (n=1), melanocyte (n=1), neuronal differentiation (n=2), and classic MB (n=1). Desmoplastic/nodular MB and MBEN can differentiate into less malignant cells types after radiotherapy and chemotherapy. Maturation of MB may be affected radiotherapy and chemotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Post-treatment maturation of medulloblastoma in children: two cases and a literature review

Zhou

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…A plausible explanation for the low gH2AX foci values in samples from 40 Gy BB-irradiated mice with the high dose * area product is the quicker (i.e., complete by 24 hours) repair of DNA damage that was directly inflicted by low doses of scatter radiation. It is also possible that the scatter dose induced an adaptive response (42,43), ameliorating the bystander/abscopal response, although we are not aware of a precedent for such an effect. To add to the complexity of systemic responses in vivo, it should be noted that in directly irradiated cell populations, the relative contribution of bystander damage, compared with directly induced damage sustained by targeted cells, increases with decreasing dose (44,45).…”

Section: Discussionmentioning

confidence: 93%

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses

et al. 2017

View full text Add to dashboard Cite

The importance of nontargeted (systemic) effects of ionizing radiation is attracting increasing attention. Exploiting synchrotron radiation generated by the Imaging and Medical Beamline at the Australian Synchrotron, we studied radiation-induced nontargeted effects in C57BL/6 mice. Mice were locally irradiated with a synchrotron X-ray broad beam and a multiplanar microbeam radiotherapy beam. To assess the influence of the beam configurations and variations in peak dose and irradiated area in the response of normal tissues outside the irradiated field at 1 and 4 days after irradiation, we monitored oxidatively induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apoptosis, and the local and systemic immune responses. All radiation settings induced pronounced persistent systemic effects in mice, which resulted from even short exposures of a small irradiated area. OCDLs were elevated in a wide variety of unirradiated normal tissues. In out-of-field duodenum, there was a trend for elevated apoptotic cell death under most irradiation conditions; however, DSBs were elevated only after exposure to lower doses. These genotoxic events were accompanied by changes in plasma concentrations of macrophage-derived cytokine, eotaxin, IL10, TIMP1, VEGF, TGFβ1, and TGFβ2, along with changes in tissues in frequencies of macrophages, neutrophils, and T lymphocytes. Overall, our findings have implications for the planning of therapeutic and diagnostic radiation treatments to reduce the risk of radiation-related adverse systemic effects. .

show abstract

“…Several studies have reported that chromosome instability varies according to the amount and the repeat number of radioactive iodine taken. Also, it was shown in studies that genetic predisposition, occupational hazard, and life style of individuals exposed to IR can also affect the damage to the cell (26,27). Seo et al (28) showed that incidence of leukemia increases with ≥100 mCi IR.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic Studies of Chromosome Abnormalities in Thyroid Cancer Patients Before and After Iodine-131 Treatment

Öden¹,

Atasoy²,

Demır³

et al. 2019

Bezmialem Science

View full text Add to dashboard Cite

Objective: Thyroid cancer is among the most common endocrine malignancies. Initial management consists surgery and ablation. I-131,which is used to damage surgically unremoved thyroid tissue or treat metastases, is a source for ionizing radiation (IR), also generates potential mutagenic and carcinogenic effects.The purpose of research is to investigate the damage on chromosomes at the I-131 treatment of thyroid cancer patients exposed to the same dose of genotoxic agent. Methods: Peripheral blood of 20 patients and 20 healthy control individuals were used in study. Materials were collected from patients before the I-131 treatment and three times on the 15 th day, the first and second month after the I-131 treatment. All chromosome abnormalities, spontaneous chromosomal breakages, and sister chromatid exchange (SCE) were analyzed by cytogenetic methods in the samples. Results: The results obtained from peripheral blood of patiens who received ablation therapy revealed no significant increase for chromosome breakages, chromosome abnormalities, and SCE. Karyotyped metaphase spreads showed none of the structural and numerical chromosome abnormalities.The results of chromosome breakages and SCE have been statistically assessed by Aspin Welch test and did not differ from the control group.The t values of this variability were found to be-1.001,-1.654, respectively, and p>0.05. Conclusion: Our results demonstrate that applied therapeutic clinical dose does not show cytogenetic abnormalities risks of the early period in patients. I-131 treatment is a good option for the treatment of thyroid cancer,but also we recommend that physicians should perform long term follow-up examinations for IR exposed patients and prevent possible complications.

show abstract

Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation

Cited by 6 publications

References 28 publications

Post-treatment maturation of medulloblastoma in children: two cases and a literature review

Post-treatment maturation of medulloblastoma in children: two cases and a literature review

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses

Cytogenetic Studies of Chromosome Abnormalities in Thyroid Cancer Patients Before and After Iodine-131 Treatment

Contact Info

Product

Resources

About