Retrospective Biodosimetry among United States Radiologic Technologists

Bhatti, Parveen; Preston, Dale L.; Doody, Michele M.; Hauptmann, Michael; Kampa, Diane; Alexander, Bruce H.; Petibone, Dayton M.; Simon, Steven L.; Weinstock, Robert M.; Bouville, André; Yong, Lee C.; Freedman, D. Michal; Mabuchi, Kiyóhiko; Linet, Martha S.; Edwards, Alan; Tucker, James D.; Sigurdson, Alice J.

doi:10.1667/rr0894.1

Cited by 36 publications

(50 citation statements)

References 40 publications

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“…Studies of exposure to diagnostic X rays (39-41) and occupational exposure received by U.S. radiologic technologists (42) in relationship to reconstructed cumulative doses also resulted in dose-response relationships in line with those derived from in vitro studies. This has led to suggestions that translocation frequency can reliably reflect cumulative exposure in low-dose protracted exposure conditions (40,42). The current study confirms a linear dose response for translocations induced by chronic lowdose occupational exposure although there is wide individual variation (Fig.…”

Section: Discussionsupporting

confidence: 75%

FISH Chromosome Analysis of Plutonium Workers from the Sellafield Nuclear Facility

Tawn¹,

Whitehouse²,

Riddell³

2006

Radiation Research

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Section: Discussionsupporting

confidence: 75%

FISH Chromosome Analysis of Plutonium Workers from the Sellafield Nuclear Facility

Tawn¹,

Whitehouse²,

Riddell³

2006

Radiation Research

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“…The occupational dosimetry system used to estimate absorbed dose to the breast has been described in detail elsewhere (18,19), with some significant refinements (20) introduced for this work. The present dosimetry version incorporates new dose factors [i.e., Gray (Gy) to breast per Sievert (Sv) of badge dose] that reflect temporal changes in X-ray machine tube potentials and filtration, more reliable estimates of photon transmission through protective aprons and shields, more precise estimates of individual-specific apron use during the years worked, and substantially greater number of occupational radiation monitoring badge readings from cohort members in the period before 1977.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in Apoptosis- and Proliferation-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among U.S. Radiologic Technologists

Sigurdson¹,

Bhatti²,

Doody³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although genes involved in apoptosis pathways and DNA repair pathways are both essential for maintaining genomic integrity, genetic variants in DNA repair have been thought to increase susceptibility to radiation carcinogenesis, but similar hypotheses have not generally been raised about apoptosis genes. For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women. Methods: In a case-control study of 859 cases and 1,083 controls within the U.S. Radiologic Technologists cohort, we assessed breast cancer risk with respect to 16 candidate variants in eight genes involved in apoptosis, inflammation, and proliferation. Using carefully reconstructed cumulative breast dose estimates from occupational and personal diagnostic ionizing radiation, we also investigated the joint effects of these polymorphisms on the risk of breast cancer. Results: In multivariate analyses, we observed a significantly decreased risk of breast cancer associated

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“…Translocations are the aberration of choice in assessing the long-term radiation damage as discussed previously. Retrospective studies in radiology technologists have shown increased translocations after exposure to low doses [72]; however, uncertainties remain for retrospective dose estimates based on biological markers of exposure.…”

Section: Biomarkers For Diagnostic and Interventional Radiologymentioning

confidence: 99%

Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy

Manning

Rothkamm²

2013

BJR

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Diagnostic and therapeutic radiation technology has developed dramatically in recent years, and its use has increased significantly, bringing clinical benefit. The use of diagnostic radiology has become widespread in modern society, particularly in paediatrics where the clinical benefit needs to be balanced with the risk of leukaemia and brain cancer increasing after exposure to low doses of radiation. With improving long-term survival rates of radiotherapy patients and the ever-increasing use of diagnostic and interventional radiology procedures, concern has risen over the long-term risks and side effects from such treatments. Biomarker development in radiology and radiotherapy has progressed significantly in recent years to investigate the effects of such use and optimise treatment. Recent biomarker development has focused on improving the limitations of established techniques by the use of automation, increasing sensitivity and developing novel biomarkers capable of quicker results. The effect of low-dose exposure (0-100 mGy) used in radiology, which is increasingly linked to cancer incidences, is being investigated, as some recent research challenges the linear-no-threshold model. Radiotherapy biomarkers are focused on identifying radiosensitive patients, determining the treatment-associated risk and allowing for a tailored and more successful treatment of cancer patients. For biomarkers in any of these areas to be successfully developed, stringent criteria must be applied in techniques and analysis of data to reduce variation among reports and allow data sets to be accurately compared. Newly developed biomarkers can then be used in combination with the established techniques to better understand and quantify the individual biological response to exposures associated with radiology tests and to personalise treatment plans for patients.

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Retrospective Biodosimetry among United States Radiologic Technologists

Cited by 36 publications

References 40 publications

FISH Chromosome Analysis of Plutonium Workers from the Sellafield Nuclear Facility

FISH Chromosome Analysis of Plutonium Workers from the Sellafield Nuclear Facility

Polymorphisms in Apoptosis- and Proliferation-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among U.S. Radiologic Technologists

Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy

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