Retrospective audit on tolerability and efficacy of duloxetine for stress urinary incontinence

Patel-Gadhia, R.; Bhal, Kiron; Patil, Prajakta Aloorkar

doi:10.3109/01443615.2010.547955

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Duloxetine is the recommended drug for the treatment of SUI, but due to the large side effects and adverse reactions of the drug, the patient's tolerance is poor, so that the patients cannot take it for a long time. [14] The American Urological Association recommends conservative treatment for mild and moderate SUI, which mainly includes pelvic floor muscle training (PFMT). [15] Although PFMT has A-level evidence of efficacy according to evidence-based guidelines, it needs to be maintained for at least 3 months, which is difficult for most female patients.…”

Section: Introductionmentioning

confidence: 99%

“…Treatments for SUI include behavioral therapy, medication, physical therapy, and surgery. Duloxetine is the recommended drug for the treatment of SUI, but due to the large side effects and adverse reactions of the drug, the patient's tolerance is poor, so that the patients cannot take it for a long time [14] . The American Urological Association recommends conservative treatment for mild and moderate SUI, which mainly includes pelvic floor muscle training (PFMT) [15] .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of moxibustion in the treatment of female stress urinary incontinence

et al. 2022

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Background:Stress urinary incontinence (SUI) is one of the common diseases in female urinary system diseases, and the incidence is increasing year by year. Moxibustion therapy, as a kind of acupuncture therapy, has been widely used in the clinical treatment of SUI, but its therapeutic effect and safety have not been scientifically and systematically evaluated. Therefore, the protocol of this systematic review we propose this time is to scientifically evaluate the effectiveness and safety of moxibustion in the treatment of female stress urinary incontinence (FSUI).Methods:The following 8 electronic databases will be searched from establishment to December 2021: PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, VIP Database, Wanfang Database, China Biology Medicine disc. All randomized controlled trials of moxibustion in the treatment of FSUI will be searched in the above electronic databases. Two reviewers will independently complete research selection, data extraction, and research quality evaluation. After screening the studies, the quality of the included studies will be evaluated according to the quality standards specified in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). The primary outcome of included studies is the change from baseline in urine leakage measured by the 1-hour pad test. Secondary outcomes include: the short-form of the International Consultation on Incontinence Questionnaire, the mean 72-hour urinary incontinence episode frequency, self-assessment of the patient's treatment effect, severity of urinary incontinence, and adverse events. Two reviewers will independently conduct study selection, data extraction, risk of bias assessment, and study quality assessment. And the STATA 14.0 software will be implemented for data synthesis and meta-analysis.Results:The result of this meta-analysis will be submitted to peer-reviewed journals for publication, and a comprehensive review of current evidence will be conducted.Conclusions:The conclusion of this systematic review will provide evidence for judging whether moxibustion is a safer and more effective intervention for female stress urinary incontinence.Trial registration number:The protocol has been registered on INPLASY2021120052.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of moxibustion in the treatment of female stress urinary incontinence

et al. 2022

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“…This result in high discontinuation rates. [ 13 ] Pelvic floor muscle training (PFMT) is one of the conservative therapies for SUI, it is more effective than no treatment, placebo drug or inactive control treatments for women with SUI. [ 14 ] However, Pelvic floor muscle training needs long-term adherence and its value remains uncertain for post-prostatectomy incontinence in men.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture and related therapies for stress urinary incontinence

et al. 2020

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Background: Stress urinary incontinence (SUI) is the most common type of urinary incontinence, affecting patients’ quality of life and sexual function. Lots of Clinical trials suggested that acupuncture is beneficial for SUI and various acupuncture methods have been widely used in clinic. However, the comparative efficacy and safety of these acupuncture methods remains unclear. Clinicians are confused to select the optimal way to treat SUI. This review aims to gather solid evidence in order to provide reliable reference in establishing guidelines for acupuncture treatment of SUI. Methods: Relevant databases including MEDLINE, Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, the Chongqing VIP Chinese Science and Technology Periodical Database will be retrieved from their inception to April 2020. The quality of the included studies will be evaluated by the risk of bias tool and the evidence will be evaluated by Grading of Recommendations Assessment, Development and Evaluation System. Network meta-analysis will be conducted by using software R3.5.1. The primary outcome is the number of patients with self-reported continence and number of patients with self-reported improvement in SUI. Results: The results of this network meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion: the results may be useful for patients, clinicians, and guideline-makers to choose the optimal acupuncture method for SUI treatment.

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“…Although duloxetine is the recommended drug for the treatment of SUI in women, it cannot be used for a long time due to the side effects and adverse reactions of the drug. (19) In severe cases, drug side effects such as arrhythmia and hypertension may occur. (20,21)Although surgery for severe stress incontinence is effective, (22,23) it may lead to an increased risk of a range of complications, such as postoperative infection, pain, and di culty urinating.…”

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confidence: 99%

Is moxibustion safe and effective in treating female stress urinary incontinence? A systematic review and meta-analysis

Zhang

Zhou

Wei

et al. 2022

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Background Stress urinary incontinence (SUI) in women is a female urogenital disease in which urine leaks out involuntarily due to increased abdominal pressure during coughing or sneezing or physical activity. As one of complementary and alternative medicine, moxibustion therapy has been widely used in the clinical treatment of female SUI, but its efficacy and safety have not been systematically evaluated. Therefore, this study aimed to systematically evaluate the efficacy and safety of moxibustion in the treatment of female SUI. Methods The following electronic databases were searched from database establishment to December 2021: PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), VIP Database, Wanfang Database, and China Biology Medicine Disc (CBM). All randomized controlled trials (RCTs) with moxibustion as an intervention for the treatment of female SUI were included in this study. The primary outcome of included studies was the change from baseline in urine leakage measured by the 1-hour pad test. Secondary outcomes included clinical efficacy, the International Consultation on Incontinence Questionnaire Short-Form (ICIQ-SF) score, mean 24-hour frequency of incontinence episodes, and adverse events. The meta-analysis was performed by STATA software (version 15.0) in this study. Results A total of 13 RCTs were included in this meta-analysis, involving 822 female SUI patients, of which 413 in the experimental group received moxibustion, and 409 in the control group received other conservative treatments (pelvic floor muscle training or acupuncture or Chinese medicine). The results of the meta-analysis showed that compared with receiving pelvic floor muscle training (PFMT) or acupuncture or Chinese medicine treatment, moxibustion intervention for female SUI reduced urine leakage in the one-hour pad test [SMD=-0.86, 95%CI (-1.03,-0.58)], significantly improved clinical efficacy [OR = 3.42, 95%CI (2.32,5.04)], decreased the ICIQ-SF score [SMD=-0.80, 95%CI (-1.03,-0.57)], and reduced average 24-hour incontinence episode frequency [SMD=-0.78, 95%CI (-1.05,-0.54)]. At the same time, no adverse events occurred during the moxibustion intervention. Conclusions Based on this meta-analysis, moxibustion, as one of the complementary and alternative medicine therapies, can be effective and safe in the treatment of female SUI. Moxibustion intervention can reduce urine leakage in the one-hour pad test, improve clinical efficacy, reduce the ICIQ-SF score, and reduce the average 24-hour frequency of urinary incontinence episodes. However, due to the low quality of evidence in this study, higher-quality RCTs are needed for further demonstration. Registration of systematic review: This systematic review and meta-analysis has been registered in the INPLASY International Registry of Prospective Systematic Reviews under the registration number INPLASY2021120052.

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Retrospective audit on tolerability and efficacy of duloxetine for stress urinary incontinence

Cited by 6 publications

References 2 publications

Efficacy and safety of moxibustion in the treatment of female stress urinary incontinence

Efficacy and safety of moxibustion in the treatment of female stress urinary incontinence

Acupuncture and related therapies for stress urinary incontinence

Is moxibustion safe and effective in treating female stress urinary incontinence? A systematic review and meta-analysis

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