Retrospective Audit of the Widal Test for Diagnosis of Typhoid Fever in Pediatric Patients in an Endemic Region

Lalremruata, Ralte; Chadha, Sanjim

doi:10.7860/jcdr/2014/7819.4373

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Widal tests were done by laboratory professionals who were blind to the study and were based on the manufacturer's guidelines, and results were given to doctors who requested the tests for patient management (Figure 4). Ibadan-Nigeria, separately among the clinically presumed typhoid fever cases [17][18][19][20][21][22][23], and furthermore in West Wollega [24] and Ambo [25], Ethiopia, which revealed 53.6% and 56.2%, Salmonella…”

Section: Resultsmentioning

confidence: 99%

"Prevalence of Enteric Fever Among Patients Attending the Student Clinic at Debre Birhan University, North Shewa, Ethiopia"

Belachew¹

2022

BJSTR

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Background: Typhoid (enteric) fever is a significant medical condition. The World Health Organization uncovered that around 21 million cases and more than six hundred thousand yearly died from typhoid fever. Non-industrialized countries share the most elevated weight because of rapid population growth, increased urbanization, and inadequate safe water and healthcare systems. Objective: This study was intended to show seroprevalence for Salmonella Typhi infection among patients attending the student clinic at Debre Birhan University. Methods: A retrospective cross-sectional study was conducted on Widal test results registered from December 2019 to June 2021 at Debre Birhan University student clinic. After official permission was obtained from the head of the student clinic, the data were retrieved from medical records (registry books) of the laboratory unit for the study period. The data were gathered and saved in excel sheets which were further analyzed by statistical package for the social sciences (SPSS) software version 20. Results. Our study revealed the seroprevalence of typhoid fever was 69.23%, (95% confidence interval [CI] = 195.58-605.42%). Among 1300 males (56.17%), 998 (76.77%) were reactive for O and H antigens (571 for O-antigen, and 427 for H-antigen, M ± SD = 499 ± 101.82), 302 (23.23%) were non-reactive for O and H antigens (231 for O-antigen and 71 for H-antigen, M ± SD = 151 ± 113.14). Of 1014 (43.82%) females, 604 (59.57%) were reactive for O and H antigens (319 for O-antigen and 285 for H-antigen, M ± SD = 302 ± 24.04), 410 (40.43%) were non-reactive for O and H antigens (135 for O-antigen and 275 for H-antigen, M ± SD = 205 ± 98.99).Conclusions: Typhoid fever is a significant general health problem in Ethiopia. Indeed, even today, an enormous number of cases are affirmed through a single semiquantitative slide Widal test, despite its known low investigative value.

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Section: Resultsmentioning

confidence: 99%

"Prevalence of Enteric Fever Among Patients Attending the Student Clinic at Debre Birhan University, North Shewa, Ethiopia"

Belachew¹

2022

BJSTR

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“…Many relied on clinical case definitions, often in combination with diagnosis based on Widal serological testing. 16 , 17 In areas where typhoid and paratyphoid A fever are both endemic, clinical case counts do not allow disease burdens to be ascribed to specific etiologic agents.…”

Section: Methodsmentioning

confidence: 99%

Typhoid Fever: Way Forward

Bhutta

Gaffey

Crump

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Abstract.The Tackling Typhoid supplement shows that typhoid fever continues to be a problem globally despite socioeconomic gains in certain settings. Morbidity remains high in many endemic countries, notably in sub-Saharan Africa and South Asia. In addition, antimicrobial resistance is a growing issue that poses a challenge for clinical management. The findings from this supplement revealed that outside of high-income countries, there were few reliable population-based estimates of typhoid and paratyphoid fever derived from surveillance systems. This indicates the need for monitoring systems that can also characterize the effectiveness of interventions, particularly in low- and middle-income settings. The country case studies indicated that gains in economic conditions, education, and environmental health may be associated with reductions in typhoid fever burden. Over the study period, the effect is mainly notable in countries with higher baseline levels of economic development, female literacy, and investments in public sanitation. High burden countries must continue to invest in strategies at the local level to address environmental factors such as access to safe drinking water and improved public sanitation that are known to interrupt transmission or diminish the risk of acquiring typhoid. Developing more effective vaccines and incorporating appropriate immunization strategies that target populations with the greatest risk could potentially alleviate disease burden.

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“…Tujuan dari uji Widal ialah untuk melihat apakah terdapat aglutinin dalam serum pasien demam tifoid berupa: aglutinin Vi (simpai kuman). 19 Kultur darah ialah baku emas penunjang untuk demam tifoid saat ini. Kultur darah merupakan uji laboratorium untuk memeriksa apakah terdapat bakteri pada sampel darah pasien.…”

Section: Hasil Dan Pembahasanunclassified

Literature Review: Gambaran Pemeriksaan Tes Widal Denganpemeriksaan Pertumbuhan Kultur Bak-Teri Salmonella Typhi Pada Pasien Demam Tifoid Anak

Paufik

Muthmainah

Rahmiati

et al. 2023

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Typhoid fever is a systemic contamination because of Salmonella typhi micro organism, with unfold via the fecal-oral route. Currently, the diagnosis of typhoid fever in Indonesia remains broadly utilized by the Widal take a look at method. From a few data, the sensitivity and specificity values of the Widal take a look at aren't as accurate because the Tubex ™ take a look at. Therefore, this has a look at will investigate a literature assessment that examines the assessment of the Widal take a look at with blood culture in pediatric typhoid fever patients. The layout of this studies is a literature review. Search for posted articles on google schoolar the usage of decided on keywords, namely: evaluate of the Widal take a look at with exam of the boom of Salmonella typhi microorganism in kids with typhoid fever. Based at the assessment results, the av-erage fee of sensitivity is 69.5%, specificity is 67.9%, fantastic predictive fee is 37.9% and poor predictive fee is 86.0%. Widal's exam of the 11 calculated journals has a low common PPV fee and an excessive common NPV fee. Sensitivity and Specificity values are within side the variety of 60%. Conclusion primarily based totally on evaluations from sev-eral journals, the Widal take a look at can not be used to verify a prognosis however to rule out the opportunity of a diagnosis of different diseases

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Retrospective Audit of the Widal Test for Diagnosis of Typhoid Fever in Pediatric Patients in an Endemic Region

Cited by 4 publications

References 14 publications

"Prevalence of Enteric Fever Among Patients Attending the Student Clinic at Debre Birhan University, North Shewa, Ethiopia"

"Prevalence of Enteric Fever Among Patients Attending the Student Clinic at Debre Birhan University, North Shewa, Ethiopia"

Typhoid Fever: Way Forward

Literature Review: Gambaran Pemeriksaan Tes Widal Denganpemeriksaan Pertumbuhan Kultur Bak-Teri Salmonella Typhi Pada Pasien Demam Tifoid Anak

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