Retrospective Analysis on 76 Cases of Cerebral Arteriovenous Malformations Treated by Gamma Knife Radiosurgery

Choe, Jae-Gyun; Im, Yong-Seok; Kim, Jong-Soo; Hong, Seung‐Chyul; Shin, Hyeonjoon; Lee, Jung-Il

doi:10.3340/jkns.2008.43.6.265

Cited by 9 publications

(12 citation statements)

References 22 publications

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“…In this study, 73.7% of patients presented with hemorrhage before SRS, which may be associated with the fact that over 50% of our patients had AVMs in a deep location. The AVMs' cumulative probability of obliteration in five years was 82.47%, results that are similar to those reported by other series [8,21,22,[27][28][29][30][31][32][33][34][40][41][42] . Complete AVMs occlusion was higher compared with that reported by Skjoth-Rasmussen et al [42] , who reported 78% occlusion in small AVMs of less than 10 cm in volume.…”

Section: Discussionsupporting

confidence: 80%

Linac Stereotactic Radiosurgery for the Treatment of Small Arteriovenous Malformations: Lower Doses Can Be Equally Effective

Flores¹,

Sallabanda²,

Santos³

et al. 2011

Stereotact Funct Neurosurg

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Objective: The purpose of this study was to examine the efficacy and toxicity of treating small arteriovenous malformations (AVMs) (≤3 cm in diameter) with a median marginal applied dose of 14 Gy. Methods: Two hundred and thirteen patients diagnosed with AVMs were treated between January 1991 and December 2005. Seventy-three percent of the patients had hemorrhaged prior to treatment, 13% had had previous surgery and 19.2% had had previous embolization. The median follow-up duration was 48.1 months. Results: The Kaplan-Meier analysis estimated that the 36-month obliteration rate was 65.5% for patients undergoing their first stereotactic radiosurgery (SRS) and 68.3% for those undergoing repeated SRS. The Kaplan-Meier analysis estimated the 60-month AVMs obliteration rate for the entire cohort to be 82.4%. The median time to AVM obliteration was 40 ± 2.8 months. We found a statistically significant relationship between the time of obliteration and the following factors: site of the AVMs (sites other than brainstem), a higher prescribed dose and a positive history of previous hemorrhage. Thirteen patients (7.6%) experienced toxicities. Conclusions: SRS was an effective and safe treatment for AVMs ≤3 cm in diameter, with acceptable toxicity.

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Section: Discussionsupporting

confidence: 80%

Linac Stereotactic Radiosurgery for the Treatment of Small Arteriovenous Malformations: Lower Doses Can Be Equally Effective

Flores¹,

Sallabanda²,

Santos³

et al. 2011

Stereotact Funct Neurosurg

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“…Thirty-three (97%) studies were from single centres and one (3%) was multi-centre (Appendix 7 ). Thirteen (39%) studies were from North America [ 4 , 14 – 16 , 18 , 41 , 43 – 45 , 52 , 56 , 66 , 74 ], 12 (36%) from Asia [ 5 , 6 , 8 , 31 , 32 , 36 , 39 , 46 , 47 , 51 , 57 , 75 ] and 8 (24%) from Europe [ 2 , 24 , 35 , 49 , 54 , 58 , 65 , 71 ].…”

Section: Resultsmentioning

confidence: 99%

“…No studies were at risk of bias due to classification of intervention or from performance bias from deviation of intended intervention. Four studies (12%) were at moderate risk of attrition bias for obliteration outcomes from loss of patients to follow-up [ 6 , 8 , 54 , 57 ]. All four studies had > 80% of total patients treated available for analysis at the end of follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…All studies were retrospective, except one which identified and followed consecutive patients prospectively (Appendix 7 ) [ 65 ]. Three studies (9%) were deemed moderate risk of reporting bias [ 6 , 8 , 56 ]. Overall, no studies were deemed to be at serious risk of bias for any of the seven domains of the ROBINS-I tool [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…Orio et al 2006 [56] and Zhao et al2008 [75] did not report venous drainage e In addition to the previously stated papers, Hasegawa et al 2018 [32] does not stratify individually but groups SM 3-5 AVMs frequency (55%) Thirty-three (97%) studies were from single centres and one (3%) was multi-centre (Appendix 7). Thirteen (39%) studies were from North America [4, 14-16, 18, 41, 43-45, 52, 56, 66, 74], 12 (36%) from Asia [5,6,8,31,32,36,39,46,47,51,57,75] and 8 (24%) from Europe [2,24,35,49,54,58,65,71].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Gamma Knife radiosurgery for cerebral arteriovenous malformations: a systematic review and meta-analysis

et al. 2022

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Materials and methods Registration and reporting standardsWe performed this systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (Appendix 1) [53]. The study protocol is published on PROSPERO (CRD 42,021,285,118). Search strategyWe performed a comprehensive literature search (Appendix 2) using OVID Medline, EMBASE, ClinicalTrials.gov, OpenGrey and Cochrane Library from 1st January 1989 to 1st September 2021 for relevant articles. We reviewed the bibliographies of included studies for further articles meeting our eligibility criteria. Eligibility criteriaWe sought randomised trials and observational cohort studies, published in English in peer-reviewed journals reporting 20 + adult (18 +) patients with AVMs, diagnosed by MRI or histopathological examination, treated with single-session GKRS. We included studies describing all the following patient and AVM characteristics: (1) median (or mean) margin dose, (2) AVM volume (or maximum nidus diameter), (3) clinical presentation, (4) AVM Spetzler-Martin grades. We included studies reporting all the following clinical and radiological outcomes, with a minimum follow-up period of 12 months following GKRS: (1) complete nidus obliteration rate (angiography or angiography/MRI-confirmed), (2) post-GKRS ICH, (3) RICs or adverse radiation effects (ARE).

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Arteriovenous Malformations of the Pineal Region: Management and Controversies

Florian

2020

Pineal Region Lesions

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Retrospective Analysis on 76 Cases of Cerebral Arteriovenous Malformations Treated by Gamma Knife Radiosurgery

Cited by 9 publications

References 22 publications

Linac Stereotactic Radiosurgery for the Treatment of Small Arteriovenous Malformations: Lower Doses Can Be Equally Effective

Linac Stereotactic Radiosurgery for the Treatment of Small Arteriovenous Malformations: Lower Doses Can Be Equally Effective

Gamma Knife radiosurgery for cerebral arteriovenous malformations: a systematic review and meta-analysis

Arteriovenous Malformations of the Pineal Region: Management and Controversies

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