Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity

Fleischman, David; Perry, Jennifer T.; Allingham, R. Rand; Stinnett, Sandra S.; Fleischman, Gita M.; Givre, Syndee; Chesnutt, David A.

doi:10.1016/j.jcjo.2016.07.021

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Extrapolating this concept, we suggested the possibility of treating papilloedema from idiopathic intracranial hypertension or from SANS by inducing permissive ocular hypertension 25. To follow-up this concept, we performed a large, retrospective study on the relationship of the translaminar pressure differential and papilloedema severity 26. The study concluded that there was no relationship between any of the significant TLPD parameters and suggested other factors must be more important in this relationship.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of optic canal anatomy and symmetry using CT

et al. 2019

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ObjectiveWe aim to describe the anatomy and symmetry patterns of the optic canal in patients having undergone maxillofacial CT imaging.MethodsIn this retrospective chart review, we included all patients who received sinus and maxillofacial CT at the University of North Carolina hospitals between 2008 and 2016, without facial or cranial fractures or other medical conditions that would affect optic canal size. We measured the length of ≥75% enclosed canal, minimum cross-sectional area and minimum diameter bilaterally using iNtuition TeraRecon (Durham, North Carolina) and compared bilateral symmetry using a 20 % difference threshold. Each parameter above was compared among white, black, non-white and non-black patients.ResultsOf 335 patients, the mean canal length was 5.61±2.22 mm. The mean minimum area was 11.84±3.11 mm2. The mean minimum diameter was 3.28±0.55 mm. A total of 39.4% (132/335) of patients had asymmetric canal lengths, 18.8% (63/335) had asymmetric minimum areas, and 12.5% (42/335) had asymmetric minimum diameters. No differences were found between racial groups. The right optic canal was larger than the left (right: 12.12 mm vs left: 11.55 mm, p<0.0001).ConclusionOptic canal asymmetry is not uncommon. It may affect risk of papilloedema severity, explain cases of unilateral or asymmetric papilloedema and possibly asymmetric glaucoma.

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Section: Discussionmentioning

confidence: 99%

Evaluation of optic canal anatomy and symmetry using CT

et al. 2019

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“… Fundus examination by direct and indirect ophthalmoscopy: to detect signs of papilledema. Grading of the papilledema was done according to the criteria of the Modified Frisen Scale 14 Assessment of the peripheral visual field : Automated perimetry was used for the assessment of the peripheral visual field.…”

Section: Methodsmentioning

confidence: 99%

Role of tumor necrosis factor‐alpha in the pathophysiology of idiopathic intracranial hypertension

et al. 2021

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Background Although the pathogenesis of idiopathic intracranial hypertension (IIH) is still poorly understood, the contribution of inflammatory mechanisms has been proposed in its pathophysiology. Objective This study aimed to measure serum tumor necrosis factor‐α (TNF‐α) levels in patients with IIH and to examine its relationship with clinical and ophthalmological parameters and cerebrospinal fluid (CSF) opening pressure. Subjects and methods Thirty‐six IIH patients and 30 healthy subjects were enrolled in the study. Patients were subjected to complete neurological, general, and ophthalmological assessments. Serum TNF‐α levels were measured for patients and controls using the enzyme‐linked immunosorbent assay. Results Serum TNF‐α levels were significantly higher in IIH patients compared to healthy controls (p value <.001). Serum TNF‐α level was significantly negatively correlated with grade of perimetry and CSF opening pressure (r = −.36, p value = .02), (r = −.37, p value = .02) respectively. However, serum TNF‐α was not significantly correlated either with age at onset, disease duration, BMI, headache severity, relapse rate, visual acuity, or papilloedema grade. Serum TNF‐α was found to be a significant predictor of the severity of the visual field affection in IIH patients, as one‐grade increase of the perimetric grading was associated with a decrease in serum TNF‐α by 13.96 ng/ml. Conclusion Altered serum TNF‐α levels may suggest the potential involvement of pro‐inflammatory mechanisms in the pathogenesis of IIH. Serum TNF‐α level may be an indicator of the severity of the visual field affection in IIH.

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“…This increase in pressure is transmitted to the OSAS, leading to the ophthalmic manifestations of the disease including papilledema and vision loss. Risk factors for papilledema severity in IIH have been studied, and only nonophthalmologic factors such as age and sex were found to be associated with the degree of papilledema [37]. Frankfort et al have extensively studied the effect of elevated CSF pressure (simulating to some degree, both IIH and SANS) in mice.…”

Section: Key Pointsmentioning

confidence: 99%

Cerebrospinal fluid and ophthalmic disease

Ford

Frankfort

Fleischman

2021

Current Opinion in Ophthalmology

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Purpose of reviewThe purpose of this review is to discuss the contemporary body of literature examining the relationship between cerebrospinal fluid (CSF) and ophthalmic disease. This review focuses on diseases that have a pathogenesis related to the translaminar pressure difference, defined as the pressure difference between the orbital subarachnoid space (OSAS) and the intraocular pressure. The diseases discussed include glaucoma, idiopathic intracranial hypertension, and spaceflight associated neuro-ocular syndrome. Recent findingsThe relationship between cerebrospinal and ophthalmic disease has been investigated for over 100 years.Recent research provides insight into the mechanisms that dictate CSF circulation in the OSAS and how alterations in these mechanism lead to disease. This review discusses these recent findings and their relationship to major ophthalmic diseases.

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Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity

Cited by 9 publications

References 20 publications

Evaluation of optic canal anatomy and symmetry using CT

Evaluation of optic canal anatomy and symmetry using CT

Role of tumor necrosis factor‐alpha in the pathophysiology of idiopathic intracranial hypertension

Cerebrospinal fluid and ophthalmic disease

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