Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center

Yusuf, Gibran Timothy; Sellars, Maria E.; Deganello, Annamaria; Cosgrove, David O.; Sidhu, Paul S.

doi:10.2214/ajr.16.16700

Cited by 96 publications

(70 citation statements)

References 25 publications

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“…24 A study based on a single-centre experience showed no immediate adverse reactions in 305 paediatric CEUS examinations and only 2 (0.7%) delayed adverse reactions. 9 In another study examining children with malignancies, only 2 of the 13 children undergoing CEUS complained of minor and self-limiting symptoms. No change attributable to the ultrasonography contrast was detected on neurological, funduscopic examination, electrocardiography and continuous pulse oximetry.…”

Section: Safetymentioning

confidence: 99%

“…use of ultrasonography contrast agents is still "off-label" for the paediatric population in Europe, it has been widely used with documented safety and accuracy. 1,9,10 A recent and important development has been the approval by the Food and Drug Administration of the use of CEUS for liver examination in children in the USA, 11 and this will alter application not only in the USA but also across the world. Ultrasound practitioners should be mindful that many drugs are used "off-label" in children, and this is not prohibited by medical regulatory authorities.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications

Rafailidis¹,

Deganello²,

Watson³

et al. 2017

BJR

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Contrast-enhanced ultrasound (CEUS) represents a complementary technique to greyscale and colour Doppler ultrasonography which allows for real-time visualization and characterization of tissue perfusion. Its inherent advantages in the child makes ultrasonography an ideal imaging modality; repeatability and good tolerance along with the avoidance of CT, a source of ionizing radiation, renders ultrasonography imaging desirable. Although currently paediatric CEUS is principally used in an "off-label" manner, ultrasonography contrast agents have received regulatory approval for assessment of paediatric focal liver lesions (FLL) in the USA. The safety of ultrasound contrast-agents is well documented in adults, as safe as or even surpassing the safety profile of CT and MR contrast agents. Except for the established intracavitary use of CEUS in voiding urosonography, i.v. paediatric applications have been introduced with promising results in the abdominal trauma initial diagnosis and follow-up, characterization and differential diagnosis of FLL and characterization of lung, pleura, renal and splenic pathology. CEUS has also been used to detect complications after paediatric transplantation, evaluate inflammatory bowel disease activity and assess tumour response to antiangiogenic therapy. The purpose of this review was to present these novel i.v. paediatric applications of CEUS and discuss their value.

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Section: Safetymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications

Rafailidis¹,

Deganello²,

Watson³

et al. 2017

BJR

Self Cite

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“…Ultrasound contrast agents have a similar safety profile in children Intravesical and intracavitary administration …”

Section: Quality and Safetymentioning

confidence: 99%

AIUM Practice Parameter for the Performance of Contrast‐Enhanced Ultrasound Examinations

2020

J of Ultrasound Medicine

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“…Lastly, CEUS could reduce a number of oncologic follow-up examinations with the use of ionizing radiation and/or general anesthesia. In a study in which the authors evaluated the utility of CEUS in children, it was shown that CEUS substantially decreased the need for further evaluation with MRI or CT. 16…”

Section: Figurementioning

confidence: 99%

Advanced Ultrasound Techniques for Pediatric Imaging

2019

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Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen tremendously. Advanced ultrasound techniques constitute a suite of new technologies that employ microbubbles to provide contrast and enhance flow visualization, elastography to measure tissue stiffness, ultrafast Doppler to deliver high spatiotemporal resolution of flow, three-and four-dimensional technique to generate accurate spatiotemporal representation of anatomy, and high-frequency imaging to delineate anatomic structures at a resolution down to 30 mm. Application of these techniques can enhance the diagnosis of organ injury, viable tumor, and vascular pathologies at bedside. This has significant clinical implications in pediatric patients who are not easy candidates for lengthy MRI or radiation-requiring examination, and are also in need of a highly sensitive bedside technique for therapeutic guidance. To best use the currently available, advanced ultrasound techniques for pediatric patients, it is necessary to understand the diagnostic utility of each technique. In this review, we will educate the readers of emerging ultrasound techniques and their respective clinical applications.

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Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center

Abstract: Pediatric CEUS is a safe and potentially cost-effective imaging modality. Using it allows reduction in the ionizing radiation associated with CT and in the gadolinium contrast administration, sedation, and anesthesia sometimes required for MRI.

Cited by 96 publications

References 25 publications

Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications

Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications

AIUM Practice Parameter for the Performance of Contrast‐Enhanced Ultrasound Examinations

Advanced Ultrasound Techniques for Pediatric Imaging

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