Retrospective analysis of the efficacy and safety of once-daily tadalafil in patient subgroups: men with mild vs moderate ED and aged &lt;50 vs ⩾50 years

Seftel, Allen D.; Shinghal, Rajesh; Kim, Edward; Samuels, Sheri M.; Ni, Xiao; Burns, Patrick R.

doi:10.1038/ijir.2012.40

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Different tadalafil adverse effects and patients who discontinued therapy owing to side symptoms have been described in the scientific literature. Seftel et al 29 found that the overall rate of adverse effects recorded in individuals taking tadalafil 5 mg was 38.2%, with headache accounting for 8.8% and dyspepsia accounting for 4.7%. Back discomfort (1.9%), myalgia (2.2%), nasal congestion (2.8%), and limb pain (2.5%) were also significant adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of continuous use of Tadalafil on male sexual function after posterior urethroplasty: A clinical trial

Nourian Kafshgari,

Farhadi,

Kohandel Gargari

et al. 2023

Urologia

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Introduction: Posterior urethral injuries in men commonly occur following pelvic and perineal trauma. Erectile dysfunction (ED), whether brought on by the severity of the initial trauma or the surgery itself, is one of the complications in these patients. Materials and methods: In this study, we divided candidates of posterior urethroplasty due to traumatic urethral injury into intervention and placebo groups; the former received continuous treatment with tadalafil (10 mg daily), and the latter received a placebo. Other services were provided equally to both groups. Before and after the intervention, both groups completed the International Index of Erectile Function version 5 (IIEF-5) questionnaire, and the findings were analyzed. Results: Forty patients were studied in groups of 20 with a mean age of 43.87 ± 15.70 years. The patient’s most common cause of urethral injury was a pelvic fracture. Before the intervention, the mean scores of IIEF for patients in the intervention group and placebo group were 14.85 ± 7.39 and 14.77 ± 6.48, respectively with no statistical significance ( p = 0.962) and patients of the groups were similar in terms of the severity of ED. The mean IIEF score in the intervention group was 20.12 ± 4.94 and in the placebo group, it was 18.05 ± 4.88 at the three-month follow-up, with no statistically significant difference ( p = 0.063). In both the intervention and placebo groups, the IIEF score was significantly increased by 5.27 ± 4.04 ( p < 0.001) and 3.27 ± 2.97 ( p < 0.001), respectively. The rate of IIEF increase in the intervention group was higher than in the placebo group during the follow-up at 3-month follow-up with statistical significance. ( p = 0.022). Conclusion: The findings of this study suggest that tadalafil, in a 3-month treatment course, may improve erectile function in individuals with mild-to-moderate ED, significantly more than placebo. However, more studies, specifically with longer duration of follow-up and larger populations, are necessary for generalizing the current findings.

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Section: Discussionmentioning

confidence: 99%

Effects of continuous use of Tadalafil on male sexual function after posterior urethroplasty: A clinical trial

Nourian Kafshgari,

Farhadi,

Kohandel Gargari

et al. 2023

Urologia

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Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a comparative randomized prospective study

Bayraktar

Albayrak

2019

Int Urol Nephrol

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Aging and sexual health: getting to the problem

et al. 2017

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Erectile dysfunction (ED) is one of the most common disorders in male and is often associated with other age-related comorbidities. The aging process affects the structural organization and function of penile erectile components such as smooth muscle cell and vascular architecture. These modifications affect penile hemodynamics by impairing cavernosal smooth muscle cell relaxation, reducing penile elasticity, compliance and promoting fibrosis. This review aims to identify the mechanisms of ED in the penile aging process in experimental and clinical data. It also highlights areas that are in need of more research. The search strategies yielded total records screened from PubMed. Clarification of the molecular mechanisms that accompanies corpus cavernosum aging and aging-associated ED will aid new perspectives in the development of novel mechanism-based therapeutic approaches. Age is not a limiting factor for ED medical management, and it is never too late to treat. Hypogonadism should be managed regardless of age, and synergistic effects have been found during testosterone (T) replacement therapy when used along with oral phosphodiesterase-5 (PDE-5) inhibitors. Therefore, the clinical management of ED related to aging can be done by therapeutic interventions that include PDE-5 inhibitors, and other pharmacological treatments.

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Retrospective analysis of the efficacy and safety of once-daily tadalafil in patient subgroups: men with mild vs moderate ED and aged <50 vs ⩾50 years

Cited by 3 publications

References 36 publications

Effects of continuous use of Tadalafil on male sexual function after posterior urethroplasty: A clinical trial

Effects of continuous use of Tadalafil on male sexual function after posterior urethroplasty: A clinical trial

Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a comparative randomized prospective study

Aging and sexual health: getting to the problem

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