Retrospective analysis of schwannoma in the oral and maxillofacial region: clinicopathological characteristics and specific pathology of ancient change

Harazono, Yosuke; Kayamori, Kou; Sakamoto, Junichiro; Akaike, Yu; Kurasawa, Yoshihisa; Tsushima, Fumihiko; Sasaki, Yuya; Harada, Hiroyuki; Yoda, Tetsuya

doi:10.1016/j.bjoms.2021.07.014

Cited by 11 publications

(14 citation statements)

References 24 publications

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“…This term should be reserved to those schwannomas that histologically show degenerative-type atypia as well as marked stromal changes ( Table 9 ). These tumors often are large-sized and long-standing and usually affect the deep soft tissues, especially the retroperitoneum or head and neck region [ 1 , 21 , 22 ]. Histologically, their characteristic features are nuclear atypia of the “degenerative type” as well as other degenerative changes, including cystic stromal changes, hemorrhages, calcifications, and diffuse stromal hyalinization [ 1 ] ( Figure 14 ).…”

Section: Schwannomamentioning

confidence: 99%

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

et al. 2022

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Peripheral nerve sheath tumors encompass a wide spectrum of lesions with different biological behavior, including both benign and malignant neoplasms as well as the recent diagnostic category, i.e., “atypical neurofibromatous neoplasm with uncertain biologic potential” to be used only for NF1 patients. Neurofibromas and schwannomas are benign Schwann-cell-derived peripheral nerve sheath tumors arising as isolated lesions or within the context of classical neurofibromatosis or schwannomatoses. Multiple tumors are a hallmark of neurofibromatosis type 1(NF1) and related forms, NF2-related-schwannomatosis (formerly NF2) or SMARCB1/LZTR1-related schwannomatoses. Perineuriomas are benign, mostly sporadic, peripheral nerve sheath tumors that show morphological, immunohistochemical, and ultrastructural features reminiscent of perineurial differentiation. Hybrid tumors exist, with the most common lesions represented by a variable mixture of neurofibromas, schwannomas, and perineuriomas. Conversely, malignant peripheral nerve sheath tumors are soft tissue sarcomas that may arise from a peripheral nerve or a pre-existing neurofibroma, and in about 50% of cases, these tumors are associated with NF1. The present review emphasizes the main clinicopathologic features of each pathological entity, focusing on the diagnostic clues and unusual morphological variants.

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Section: Schwannomamentioning

confidence: 99%

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

et al. 2022

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“…31 Harazano et al (2022) presented retrospective histopathological analysis of forty schwannomas localized in the oral and maxillofacial region. 32 Among the anatomical areas of the schwannoma cases presented in their study were-tongue (45 percent), lower lip (17.5 percent), hard palate (10 percent), parotid gland (5 percent), buccal mucosa (7.5 percent), mandible (7.5 percent) 33 , floor of the mouth (2.5 percent), maxilla (2.5 percent), and cheek (2.5 percent). 32 The existed and described histopathological variants are: two main patterns (Antoni A and B) (i.e., classic schwannoma) and multiple subtypes-ancient, plexiform, cellular, and epithelioid.…”

Section: Discussionmentioning

confidence: 99%

“…32 The existed and described histopathological variants are: two main patterns (Antoni A and B) (i.e., classic schwannoma) and multiple subtypes-ancient, plexiform, cellular, and epithelioid. 32 Ancient (i.e., degenerative) neurilemmomas are uncommon in oral and maxillofacial area. 32 It's important to know that schwannomas can have pathological characteristics of both main patterns and ancient changes or can show no evidence of Antoni A and B patterns and degenerative subtype.…”

Section: Discussionmentioning

confidence: 99%

“…32 Ancient (i.e., degenerative) neurilemmomas are uncommon in oral and maxillofacial area. 32 It's important to know that schwannomas can have pathological characteristics of both main patterns and ancient changes or can show no evidence of Antoni A and B patterns and degenerative subtype. 32 In general, the authors categorized histopathological combinations into 8 variants.…”

Section: Discussionmentioning

confidence: 99%

“…32 It's important to know that schwannomas can have pathological characteristics of both main patterns and ancient changes or can show no evidence of Antoni A and B patterns and degenerative subtype. 32 In general, the authors categorized histopathological combinations into 8 variants. 32 Our case supports the thesis of Winter et al (2020) who emphasized that US is a well-established, non-invasive, and easily repeatable first-line tool in diagnostics of soft tissue tumors.…”

Section: Discussionmentioning

confidence: 99%

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Schwannoma of the Tongue: Ultrasonography

Demidov

Cherniak

Snisarevskyi

et al. 2022

J. Diagn. Treat. Oral Maxillofac. Pathol.

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Schwannoma is a rare benign tumor originated from the Schwann cells of the nerve sheath. Other common names are neurilemmoma, neurinoma, and neurinoma of Verocay. The tumor is encapsulated and shows slow growth reaching even the 8.5-cm size. The purpose of this paper is to provide clinical presentation, sonogram and ultrasound video of schwannoma of the tongue, its analysis along with intraoperative and histopathological data. A 27-year-old female patient with tongue schwannoma is presented and analysis of the published schwannoma cases in different anatomical areas is performed. Distinctive sonographic features of this type of tumor are showed and comparison with the other tongue masses is highlighted. Ultrasonography proved its efficacy as a first-line diagnostic tool which needs to be popularized among oral and maxillofacial surgeons.

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Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis

Tsuchiya,

Ikemura,

Miyawaki

et al. 2024

Brain Tumor Pathol

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Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in pathology. Although it is considered a benign tumor, most previous reports have focused on extracranial AS; therefore, the clinical characteristics of intracranial AS is not clear. We included 174 patients who underwent surgery for sporadic intracranial schwannoma, and 13 patients (7.5%) were diagnosed with AS. Cysts were significantly more common in patients with AS than conventional schwannomas (92.3% vs. 44.7%, p < 0.001), as was bleeding (38.5% vs. 6.9%, p = 0.003) and calcification (15.4% vs. 1.3%, p = 0.029). The maximum tumor diameter was also larger in patients with AS (35 mm vs. 29 mm, p = 0.017). The median duration from symptom onset to surgery (7.0 vs. 12.5 months, p = 0.740) did not significantly differ between groups, nor did the probability of postoperative recurrence (p = 0.949). Intracranial AS was strongly associated with cyst formation and exhibited a benign clinical course with a lower rate of recurrence and need for salvage treatment. Extracranial AS is reportedly characterized by a slow progression through a long-term clinical course, whereas intracranial AS did not progress slowly in our study and exhibited different clinical features to those reported for extracranial AS.

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Retrospective analysis of schwannoma in the oral and maxillofacial region: clinicopathological characteristics and specific pathology of ancient change

Cited by 11 publications

References 24 publications

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

Schwannoma of the Tongue: Ultrasonography

Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis

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