Retrospective analysis of risk factors for COVID-19 in the working population

Zhidkova, Elena A.; Gutor, Ekaterina M.; Tkachenko, Yu.А.; Рогова, И В; Popova, I.A.; Gurevich, K. G.

doi:10.33029/2305-3496-2021-10-2-25-30

Cited by 2 publications

(2 citation statements)

References 15 publications

(16 reference statements)

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“…С самого начала пандемии специалисты здравоохранения всех стран мира активно включились в изучение новой инфекции, ее эпидемиологических, клинических и иммунопатологических особенностей, разработку и внедрение в практику новых средств для ее успешной профилактики и эффективного лечения [3][4][5][6][7][8]. Наиболее значимы такие исследования для лиц из профессиональных групп риска инфицирования SARS-CoV-2, в том числе работников медицинских организаций (МО), которые первыми встретились с новым заболеванием и стали наиболее пострадавшей группой населения.…”

Section: технологии полногеномного секвенирования Sars-cov-2 для опре...unclassified

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

Platonova¹,

Голубкова²,

Sklyar³

et al. 2023

Health Risk Analysis

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Under the COVID-19 pandemic, healthcare workers were at the highest risk of getting infected with the disease; this necessitates specialized studies in this occupational group. The aim of the study was to identify non-occupational risk factors and laboratory markers indicating that severe clinical forms of new coronavirus infection would probably develop in healthcare workers in the initial period of the pandemic. The study included 366 workers who suffered COVID-19 in 2020–2021. The disease was confirmed by examining smears from the pharynx and nose with PCR. Some of the samples were examined using the SARS-CoV-2 whole genome sequencing technology. To determine laboratory prognostic indicators evidencing the development of more severe forms of the disease (pneumonia), a number of healthcare workers underwent laboratory examination during the acute period of the disease, namely: general clinical and biochemical blood tests, immunophenotyping of lymphocytes, analysis of the hemostasis system and cytokine levels. To study non-occupational risk factors of pneumonia, all healthcare workers after recovery were asked to fill in a Google form developed by the authors. The most severe clinical forms of COVID-19 were registered in healthcare workers who were older than 40 years, with low physical activity and a body mass index higher than 25.0, had diabetes mellitus and chronic diseases of the genitourinary system. When analyzing the results of laboratory tests, markers indicating development of pneumonia were identified and their critical values (cut-off points) were determined: the level of lymphocytes (below 1.955•109/l), T-cytotoxic lymphocytes (below 0.455•109/l), T-helpers (below 0.855•109/L), natural killers (below 0.205•109/l), platelets (below 239•109/L), erythrocyte sedimentation rate (above 11.5 mm/h), D-dimer (above 0.325 mcg/ml), total protein (below 71.55 g/L), lactate dehydrogenase (above 196 U/L), C-reactive protein (above 4.17 mg/l), and interleukin-6 (above 3.63 pg/l). The study identified non-occupational risk factors causing development of severe COVID-19 and established laboratory prognostic indicators.

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Section: технологии полногеномного секвенирования Sars-cov-2 для опре...unclassified

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

Platonova¹,

Голубкова²,

Sklyar³

et al. 2023

Health Risk Analysis

View full text Add to dashboard Cite

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“…В других работах также отмечено, что по мере распространения пандемии COVID19 прогрес сивно увеличивается средний возраст пациентов, а также нарастает число больных с сопутствующи ми заболеваниями (в 4,2 раза) [54,55]. В таких случаях подавляющее большинство больных имели тяжелые коморбидные заболевания (70,7%).…”

Section: ветряная оспа + Covid-19unclassified

A new coronavirus infection: aspects of complex comorbidity

Шкарин

Kovalishena

Murtayeva

et al. 2022

Epidemiology and Vaccinal Prevention

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Relevance. Currently, there is a significant increase in the combination of infectious and non-infectious pathology. as well as increasing the attention of researchers to this problem. The purpose. of this article is to review scientific data on the combination of the new coronavirus infection COVID-19 with infectious and non-infectious pathology and to assess the phenomenon of complex comorbidity in relation to this new infection. Results. It was found that patients 60 years and older - all have complex comorbidity, which increases the risk of death by more than 7 times, and the presence of two or more comorbid diseases in patients compared with patients who had no more than one disease, the risk of death increased by 9 times. Conclusion. A high potential of combination with COVID-19 is shown, primarily with tuberculosis, HIV infection, hepatitis B and C, as well as with a large group of opportunistic infections.

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Retrospective analysis of risk factors for COVID-19 in the working population

Cited by 2 publications

References 15 publications

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

A new coronavirus infection: aspects of complex comorbidity

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