Retrospective Analysis of Pre Operative Evaluation of Ovarian Masses Using Rm1 - 1 and Rm1 - 2

Abstract

Ovarian cancer is a commonly diagnosed and particularly deadly gynaecologic malignancy Worldwide. Among the gynecological malignancies ovarian cancer is usually diagnosed in late stages due to the lack of presenting symptoms and the lack of efficient and reliable screening test. The objective of this retrospective analysis study was to assess the accuracy of tumor marker CA 125 and RMI (Risk malignancy index) scoring one and two systems in predicting the risk in malignant ovarian masses METHODS: A retrospective analysis of a total of 300 patients with ovarian masses was done in terms of symptoms, ultrasound findings and menopausal status and CA 125 was done. After calculating the RMI one and two, a correlation with the post-operative histopathology of the ovarian masses was done. RESULTS: The sensitivity of tumor marker CA 125, RMI 1 scoring and RMI 2 scoring in predicting malignancy was found to be60, 75 and 60 percent respectively. The specificity value of tumor marker CA 125, RMI 1 scoring and RMI 2 scoring in prediction was found to be 88, 96 and 92 percent respectively. The negative predictive value of tumor marker CA 125, RMI 1 scoring and RMI 2 scoring in malignancy assessment was found to be 91.6,96 and 92 percent respectively. CONCLUSION: This study showed that thought CA 125, RMI ONE AND TWO systems are of use in assessing the risk of malignancy in ovarian masses, RMI I had the highest specificity, sensitivity and negative predictive value of the three. Whenever in doubt of the risk of malignancy, it is better to include RMI ONE scoring as a part of preliminary assessment of ovarian masses.