Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclampsia

Ahmed, Y; Iddekinge, B. Van; Paul, C.; Sullivan, M.; Elder, M.G.

doi:10.1016/0020-7292(93)90342-t

Cited by 20 publications

(26 citation statements)

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“…In normal pregnancy, an increase in platelet aggregation and a decrease in the number of circulating platelets with gestation occur [15,16]. Also, platelet lifespan declines and the MPV increase minimally during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

Sarı¹,

Tanoğlu²,

Mahmutoğlu³

et al. 2016

Med-Science

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Section: Discussionmentioning

confidence: 99%

Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

Sarı¹,

Tanoğlu²,

Mahmutoğlu³

et al. 2016

Med-Science

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“…Sejeny in 1975 [6] was the first to report gestational thrombocytopenia in 405 healthy pregnant women using electronic particle counter [6]. Since then, a number of global reports described a sequential reduction of platelet count as pregnancy advances [7][8][9][10][11][12][13][14][15][16][17][18] with a 10-20% fall in platelet count [19]. Frequency of gestational thrombocytopenia was estimated to be 7-12% at term [12,14,15].…”

Section: Quantitative Changes In Plateletsmentioning

confidence: 99%

“…Since then, a number of global reports described a sequential reduction of platelet count as pregnancy advances [7][8][9][10][11][12][13][14][15][16][17][18] with a 10-20% fall in platelet count [19]. Frequency of gestational thrombocytopenia was estimated to be 7-12% at term [12,14,15]. A platelet count of 80 x 10 9 /L is considered to be a safe threshold [20] with no impact on either mother [21] or the fetus [15], unless the thrombocytopenic mother has some comorbids [14].…”

Section: Quantitative Changes In Plateletsmentioning

confidence: 99%

“…Since there are hemostatic alterations in normal pregnancy and puerperium, the health care providers should be mindful of these changes. Reference intervals of various parameters in normal pregnancy and puerperium have been defined in several reports [12,14,16,22,23,[46][47][48][49]. It is important that laboratories analyzing coagulation profile in pregnant women should use these reference intervals.…”

Section: Practical Implications Of Physiological Changes In Hemostasismentioning

confidence: 99%

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A Review of Hemostasis in Normal Pregnancy and Puerperium

Moiz¹

2017

Natl. j. health sci.

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Significant alterations are seen in hemostatic system during normal pregnancy and puerperium. Overall, it is a state of hypercoagulability and hypofibrinolysis mitigating the risk of severe bleeding during placental separation at delivery. On the flip side, it threatens a pregnant woman for thrombosis with the risk being four to six folds more in comparison to a non-pregnant woman. It is important to understand the hemostatic changes in normal pregnancy by all health care providers who manage pregnant women in obstetric wards, trauma, anesthesia and other circumstances. This review describes the changes in qualitative and quantitative changes in platelet, clotting factors, anticoagulants and fibrinolysis during normal pregnancy and puerperium.

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“…The platelet count decreases in the presence of preeclampsia [1,2], but does not usually change during normal pregnancies [1][2][3]. However, cross-sectional studies showed that 756 (5.4%) of 13,925 women and 74 (4.6%) of 1,621 women exhibited unexplained thrombocytopenia (^150 !…”

Section: Introductionmentioning

confidence: 99%

Relation between Gestational Thrombocytopenia and the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP Syndrome)

Minakami

Kohmura²,

Izumi³

et al. 1998

Gynecol Obstet Invest

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Objective: To define the clinical features of gestational thrombocytopenia and to determine its relationship to the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). Study Design: Retrospective cohort study. We reviewed the records of 24 women with gestational thrombocytopenia among 637 nonpreeclamptic women who had serial determinations of the platelet count during pregnancy between 1992 and 1995. Gestational thrombocytopenia was defined as an antenatal gradual decline in the platelet count to <150 × 10⁹/l in nonpreeclamptic women. The control group consisted of 213 nonpreeclamptic women whose platelet counts were ≥150 × 10⁹/l at –3 to 0 days from delivery and in whom the perinatal serum level of aspartate transaminase (AST) had been determined. Results: The platelet count decreased gradually, from 210 ± 31 × 10⁹/l at <13 weeks’ gestation to 127 ± 24 × 10⁹/l at –3 to 0 days from delivery, in the 24 women with gestational thrombocytopenia. The platelet count was 251 ± 62 × 10⁹/l at –3 to 0 days from delivery in the 213 control women. The serum level of AST was elevated perinatally in 5 (21%) of 24 women with gestational thrombocytopenia compared with 6 (2.8%) of the 213 control subjects (p < 0.001). There had been 28 previous term or near-term pregnancies among 17 women with gestational thrombocytopenia, 14 of which were complicated by gestational thrombocytopenia or a decline in the platelet count by >50 × 10⁹/l; 1 pregnancy was associated with the features typical of the HELLP syndrome. Conclusion: Gestational thrombocytopenia may be a risk factor for the development of the HELLP syndrome and is likely to recur in subsequent pregnancies.

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Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclampsia

Cited by 20 publications

References 0 publications

Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

A Review of Hemostasis in Normal Pregnancy and Puerperium

Relation between Gestational Thrombocytopenia and the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP Syndrome)

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