Retrospective Analysis of Local Sensorimotor Deficits After Radial Artery Harvesting for Coronary Artery Bypass Grafting

Shah, Salman A.; Chark, Davin; Williams, J. F.; Hessheimer, Amelia J.; Huh, Jeannie; Wu, Yichen; Chang, Paul; Scholl, Frank G.; Drinkwater, Davis C.

doi:10.1016/j.jss.2006.10.006

Cited by 6 publications

(2 citation statements)

References 30 publications

(34 reference statements)

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“…Аутоартерии (грудные, лучевые) и аутовены (большая подкожная) по многим показателям пригодны для трансплантации в коронарное русло [9]. К недостаткам данного вида трансплантатов можно отнести: анатомические особенности строения сосуда, не допускающие к использованию в качестве пластического материала; ограничение количества артерий и вен; возможную травматизацию как сосуда, так и окружающих тканей при изъятии; риск развития ишемии в месте забора материала; воз растную дегенерацию [10,11]. Одновременно ведутся разработки в области создания алло-и ксенографтов.…”

Section: ауто- ксено- аллотрансплантатыunclassified

Biodegradable small-diameter vascular graft: types of modification with bioactive molecules and RGD peptides

Senokosova

Кривкина

Антонова

et al. 2020

RJTAO

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The need for small-diameter grafts for replacing the damaged area of the blood pool is still very high. These grafts are very popular for coronary artery bypass grafting. Polymeric synthetic grafts are an alternative to autografts. A promising area of tissue engineering is the creation of a biodegradable graft. It can serve as the basis for de novo generation of vascular tissue directly in the patient’s body. Optimization of the polymer composition of products has led to improved physicomechanical and biocompatible properties of the products. However, the improvements are still far from needed. One of the decisive factors in the reliability of a small-diameter vascular graft is the early formation of endothelial lining on its inner surface, which can provide atrombogenic effect and full lumen of the future newly formed vessel. To achieve this goal, grafts are modified by incorporating bioactive molecules or functionally active peptide sequences into the polymer composition or immobilizing on its inner surface. Peptide sequences include cell adhesion site – arginine-glycine-aspartic acid (RGD peptide). This sequence is present in most extracellular matrix proteins and has a tropism for integrin receptors of endothelial cells. Many studies have shown that imitation of the functional activity of the natural extracellular matrix can promote spontaneous endothelization of the inner surface of a vascular graft. Moreover, configuration of the RGD peptide determines the survival and differentiation of endothelial cells. The linker through which the peptide is crosslinked to the polymer surface determines the bioavailability of the RGD peptide for endothelial cells.

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Section: ауто- ксено- аллотрансплантатыunclassified

Biodegradable small-diameter vascular graft: types of modification with bioactive molecules and RGD peptides

Senokosova

Кривкина

Антонова

et al. 2020

RJTAO

View full text Add to dashboard Cite

show abstract

“…Based on a review of previously published information, [2][3][4][5][6][7][8][9][10][11][12][13][14][15] the hypothesis tested in this study is that sensory and motor dysfunction associated with procurement of the radial artery largely resolves within a year of surgery and is not substantially worse than the discomfort associated with procurement of the saphenous vein. To our knowledge, no trial to date includes all attributes of CSP 474 (ie, a multicenter prospective randomized trial with quantitative assessments of pain and motor function by trained personnel that use widely accepted measurement tools at specified times before and after surgery) (details of prior literature in Table 1).…”

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confidence: 99%