Retrospective analysis of jaw biopsies in young adults. A study of 1599 cases in Southern Brazil

Abstract

BackgroundTo evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis.Material and MethodsIn this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected. The histological diagnosis were grouped into the categories Cystic lesions of odontogenic origin, Periapical inflammation, Odontogenic tumors, Bone diseases, Health tissue and Nonspecific diagnostic. Absolute and relative frequencies were estimated with descriptive analysis. The agreement between clinical and histological diagnosis was measured through Kappa statistic.ResultsA total of 18,181 histopathological analysis were performed during the period of the study, registering 1,599 jaw lesions in young adults. The average age of individuals was 24,59 years (SD 3,1). Nine hundred ninety-one (62%) lesions were found in females and 608 (38%) in males. More than half of pathologies were cystic lesions of odontogenic origin (822/51.4%), followed by periapical inflammation (282/17.6%). Regarding the site of lesions, more than half occurred in posterior mandible (877/54.8%), followed by posterior maxilla (339/21.2%). The most frequent entities were periapical cyst, chronic periapical granuloma, dental follicle and paradental cyst, corresponding to a total of 1,202 (75.2%) evaluated cases. In relation to the analysis of concordance between clinical and histological diagnosis the general Kappa index was 0.5, which is considered moderate. Finally, the findings confirm data from literature about the most frequent jaw pathologies in young adults and serve as aid for preventive measures of some entities. Additionally, they can improve the formulation of differential diagnosis and the patient management. Key words: Jaw, biopsy, retrospective studies, young adult, Brazil.

Epidemiology, treatment, and recurrence of odontogenic and non-odontogenic cysts in South Sulawesi, Indonesia: A 6-year retrospective study

“…Epidemiological studies are known as the basis for formulating health policies ( 10 , 13 ). Knowledge of the most common diseases, including their etiologies, risk factors, prevention, and treatments, is also useful ( 10 ).…”

“…Knowledge of the biological characteristics, basic features, and histopathological behaviors of cystic lesions in the OMF region is key to ensuring an early clinical diagnosis, a prompt treatment, and a favorable prognosis ( 8 - 10 ). In most cases, diagnosis of odontogenic and non-odontogenic cysts can be challenging owing to their quiescent progression and similar clinical and radiographic characteristics ( 11 - 13 ). The asymptomatic nature of these cysts in the initial phase delays diagnosis and treatment and thereby leads to aggressive growth of the cysts and destruction of adjacent regions such as the maxillary sinus and mandibular nerve ( 14 - 16 ).…”

Correlation of Clinical and Histopathological Diagnosis of Oral Mucosa Lesions at the University of Costa Rica Between 2008 and 2015

“…Estos resultados concuerdan con lo reportado por Souza y cols. (14) y difieren de los reportados por otros investigadores con índices Kappa moderado (15).En otros estudios similares se reportaron porcentajes de concordancia del diagnóstico clínico/histopatológico mayores al 70 (10,16) y menores al 50% (17).…”

Clinical and Histopathological Concordance of oral Bone Lesions. Retrospective Study

“…Los datos de este estudio revelan una mayor prevalencia de lesiones óseas orales en hombres, esta tendencia se ha informado en otros estudios (15,16); sin embargo, nuestros datos difieren de otros que informan una alta prevalencia en mujeres (1,(17)(18)(19). Las lesiones estudiadas se observaron con mayor frecuencia en la sexta década de vida, a diferencia de otros estudios que han reportado una mayor frecuencia entre la segunda y cuarta décadas de la vida (16,19).…”

“…Según la ubicación anatómica, la mayoría de las lesiones óseas afectaron la mandíbula, particularmente la región posterior seguida de la región anterior de la maxila. Estas regiones han sido reportadas como la ubicación más común de QO en otros estudios (1,20,22). También son ubicaciones comunes reportadas para los TO (35,36).…”