Retrospective analysis of detomidine infusion for standing chemical restraint in 51 horses

Wilson, David B.; Bohart, GV; Evans, AT; Robertson, Sheilah A.; Rondenay, Yves

doi:10.1046/j.1467-2987.2001.00047.x

Cited by 40 publications

(27 citation statements)

References 7 publications

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“…Although the answer is ''yes'' in most cases, some individual cases may be amenable to standing chemical restraint combined with local and regional techniques. A recent study reported the use of detomidine constant rate infusion (CRI) to provide prolonged chemical restraint for as long as 135 minutes [23]. Adjunct techniques, including local or epidural anesthesia, were needed to complete the various surgical procedures when detomidine CRI was used [23].…”

Section: Preanesthetic Assessment and Cardiopulmonary Stabilizationmentioning

confidence: 99%

“…A recent study reported the use of detomidine constant rate infusion (CRI) to provide prolonged chemical restraint for as long as 135 minutes [23]. Adjunct techniques, including local or epidural anesthesia, were needed to complete the various surgical procedures when detomidine CRI was used [23]. The detomidine CRI protocol included an initial bolus-loading dose followed by temporally decreasing the detomidine CRI (Table 1).…”

Section: Preanesthetic Assessment and Cardiopulmonary Stabilizationmentioning

confidence: 99%

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Anesthesia of the critically ill equine patient

Cornick-Seahorn¹

2004

Veterinary Clinics of North America: Equine Practice

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Section: Preanesthetic Assessment and Cardiopulmonary Stabilizationmentioning

confidence: 99%

Section: Preanesthetic Assessment and Cardiopulmonary Stabilizationmentioning

confidence: 99%

Anesthesia of the critically ill equine patient

Cornick-Seahorn¹

2004

Veterinary Clinics of North America: Equine Practice

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“…Detomidine, an alpha-2-adrenergic agonist, and butorphanol are used frequently in equine clinical practice (Clarke and Paton, 1988;Riebold et al, 1995;Wilson et al, 2002;Latimer et al, 2003). Our hypothesis was that the use of detomidine alone and in combination with butorphanol has a powerful influence on brain electroencephalographic and electromyographic activity in standing horses.…”

mentioning

confidence: 92%

Electroencephalographic and electromyographic changes during the use of detomidine and detomidine-butorphanol combination in standing horses

Kruljc

Nemec

2006

Acta Veterinaria Hungarica

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Clinically, the use of detomidine and butorphanol is suitable for sedation and deepening of analgosedation. The aim of our study was to establish the influence of detomidine used alone and a butorphanol-detomidine combination on brain activity and to evaluate and compare brain responses (using electroencephalography, EEG) by recording SEF 90 (spectral edge frequency 90%), individual brain wave fractions (beta, alpha, theta and delta) and electromyographic (EMG) changes in the left temporal muscle in standing horses. Ten clinically healthy cold-blooded horses were divided into two groups of five animals each. Group I received detomidine and Group II received detomidine followed by butorphanol 10 min later. SEF 90 , individual brain wave fractions and EMG were recorded with a pEEG (processed EEG) monitor using computerised processed electroencephalography and electromyography. The present study found that detomidine alone and the detomidine-butorphanol combination significantly reduced SEF 90 and EMG, and they caused changes in individual brain wave fractions during sedation and particularly during analgosedation. The EMG results showed that the detomidine-butorphanol combination provided greater and longer muscle relaxation. Our EEG and EMG results confirmed that the detomidine-butorphanol combination is safer and more appropriate for painless and non-painless procedures on standing horses compared to detomidine alone.

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“…The use of detomidine was not considered an experimental variable in the study as the sedative was used on both experimental and control scans. This α 2 adrenoreceptor agonist is commonly used as an effective sedative and analgesic in horses 30 . Detomidine decreases the heart rate resulting in a reduction of the cardiac output.…”

Section: Discussionmentioning

confidence: 99%

EFFECTS OF ACEPROMAZINE ON THREE‐PHASE^99mTc‐MDP BONE IMAGING IN 11 HORSES

Solano

Welcome

Johnson

2005

Vet Radiology Ultrasound

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Horses undergoing skeletal scintigraphy can have decreased radiopharmaceutical bone uptake in the limbs. This reduces the diagnostic value of the scan. The aim of the present study was to measure the changes in count density caused by vasodilatation and increased blood flow associated with intravenous injection of acepromazine during bone scintigraphy in normal horses. A three-phase bone scan was performed twice in 11 adult horses to study the effects of acepromazine on the count density of the resultant scintigrams. With acepromazine, there was a statistically significant mean difference of 12 s for initial blood flow and 21 s for peak flow. The time to initial blood flow and time to peak flow occurred earlier for the scans in which acepromazine was used. There were no significant differences in the bone to soft tissue ratios during the soft tissue and bone phases of the scan between procedures. Intravenous administration of acepromazine increases peripheral blood flow causing an earlier onset of the vascular phase during the three-phase bone scan. Acepromazine did not increase the count density of the bone phase scintigrams. As expected, the vasodilatation and increased blood flow associated with intravenous injection of acepromazine affected the count density of the vascular phase of the bone scan.

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Retrospective analysis of detomidine infusion for standing chemical restraint in 51 horses

Cited by 40 publications

References 7 publications

Anesthesia of the critically ill equine patient

Anesthesia of the critically ill equine patient

Electroencephalographic and electromyographic changes during the use of detomidine and detomidine-butorphanol combination in standing horses

EFFECTS OF ACEPROMAZINE ON THREE‐PHASE^99mTc‐MDP BONE IMAGING IN 11 HORSES

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Retrospective analysis of detomidine infusion for standing chemical restraint in 51 horses

Cited by 40 publications

References 7 publications

Anesthesia of the critically ill equine patient

Anesthesia of the critically ill equine patient

Electroencephalographic and electromyographic changes during the use of detomidine and detomidine-butorphanol combination in standing horses

EFFECTS OF ACEPROMAZINE ON THREE‐PHASE99mTc‐MDP BONE IMAGING IN 11 HORSES

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EFFECTS OF ACEPROMAZINE ON THREE‐PHASE^99mTc‐MDP BONE IMAGING IN 11 HORSES