Retrospective analysis of CT-guided percutaneous cryoablation for treatment of painful osteolytic bone metastasis

Yang, Yumei; Li, Yong; Yun-xia, WU; Qiu, Shaofu; Liu, Chunlin; Wang, Qiuyu; Hong, Yuefei; Lyu, Jialing; Zhang, Yanfang; Du, Duanming

doi:10.1016/j.cryobiol.2020.01.012

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…Yang et al [ 92 ] observed a total of 26 patients (with 36 metastatic bone lesions) who were treated with CA between May 2012 and June 2016. The overall pain response rate was 91.7%, 94.4%, 91.7%, and 94.4%, respectively, at 1 day, 1 month, 3 months, and 6 months after CA, with CR achieved at 22.2%, 41.7%, 36.1%, and 22.2%, respectively.…”

Section: Literature Search Strategy and Results—interventional Strate...mentioning

confidence: 99%

Interventional Radiology in the Management of Metastases and Bone Tumors

Sgalambro

Zugaro

Bruno

et al. 2022

JCM

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Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc.). Primary malignant bone tumors are extremely rare compared with secondary bone lesions: osteosarcoma, Ewing sarcoma, and chondrosarcoma are the most common; however, the role of interventional radiology in this fiels is marginal. In this review, the main techniques used in interventional radiology were examined, and advantages and limitations illustrated. Techniques of ablation (Radiofrequency, Microwaves, Cryoablation as also magnetic resonance imaging-guided high-intensity focused ultrasound), embolization, and Cementoplasty will be described. The techniques of ablation work by destruction of pathological tissue by thermal energy (by an increase of temperature up to 90 °C with the exception of the Cryoablation that works by freezing the tissue up to −40 °C). Embolization creates an ischemic necrosis by the occlusion of the arterial vessels that feed the tumor. Finally, cementoplasty has the aim of strengthening bone segment weakened by the growth of pathological tissue through the injection of cement. The results of the treatments performed so far were also assessed and presented focused the attention on the management of bone metastasis.

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Section: Literature Search Strategy and Results—interventional Strate...mentioning

confidence: 99%

Interventional Radiology in the Management of Metastases and Bone Tumors

Sgalambro

Zugaro

Bruno

et al. 2022

JCM

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“…Good tumour-free survival rates (67-68% at one year) are reported for RFA, MWA and CA in oligometastatic metastases, including sarcoma [6,21,76]. Thermal ablation achieves effective pain relief [4,5,25,48,64,66,[77][78][79][80][81][82]84]. Multiple studies have found improved pain relief in spinal lesions when ablation was combined with vertebroplasty and/or RT [85][86][87].…”

Section: Malignant Bone Lesionsmentioning

confidence: 99%

CIRSE Standards of Practice on Thermal Ablation of Bone Tumours

Ryan

Byrne

Pusceddu³

et al. 2022

Cardiovasc Intervent Radiol

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Background Percutaneous thermal ablation is an effective, minimally invasive means of treating a variety of focal benign and malignant osseous lesions. To determine the role of ablation in individual cases, multidisciplinary team (MDT) discussion is required to assess the suitability and feasibility of a thermal ablative approach, to select the most appropriate technique and to set the goals of treatment i.e. curative or palliative. Purpose This document will presume the indication for treatment is clear and approved by the MDT and will define the standards required for the performance of each modality. CIRSE Standards of Practice documents are not intended to impose a standard of clinical patient care, but recommend a reasonable approach to, and best practices for, the performance of thermal ablation of bone tumours. Methods The writing group was established by the CIRSE Standards of Practice Committee and consisted of five clinicians with internationally recognised expertise in thermal ablation of bone tumours. The writing group reviewed the existing literature on thermal ablation of bone tumours, performing a pragmatic evidence search using PubMed to search for publications in English and relating to human subjects from 2009 to 2019. Selected studies published in 2020 and 2021 during the course of writing these standards were subsequently included. The final recommendations were formulated through consensus. Results Recommendations were produced for the performance of thermal ablation of bone tumours taking into account the biologic behaviour of the tumour and the therapeutic intent of the procedure. Recommendations are provided based on lesion characteristics and thermal modality, for the use of tissue monitoring and protection, and for the appropriately timed application of adjunctive procedures such as osseus consolidation and transarterial embolisation. Results Percutaneous thermal ablation has an established role in the successful management of bone lesions, with both curative and palliative intent. This Standards of Practice document provides up-to-date recommendations for the safe performance of thermal ablation of bone tumours.

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“…The evident drawback of this approach is the absence of real-time monitoring of tissue freezing. Therefore, it is desirable to use other techniques for monitoring, such as ultrasound (US) [ 19 , 20 ] and magnetic resonance imaging (MRI) [ 21 , 22 , 23 ], computed tomography (CT) [ 24 , 25 ] and temperature measurements [ 26 ]. Visualization by US, CT and MRI requires additional sensors or even expensive systems that can not be combined with the cryosurgical instrument.…”

Section: Introductionmentioning

confidence: 99%

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

Zotov,

Pushkarev,

Alekseeva

et al. 2024

Sensors

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This work describes a sapphire cryo-applicator with the ability to sense tissue freezing depth during cryosurgery by illumination of tissue and analyzing diffuse optical signals in a steady-state regime. The applicator was manufactured by the crystal growth technique and has several spatially resolved internal channels for accommodating optical fibers. The method of reconstructing freezing depth proposed in this work requires one illumination and two detection channels. The analysis of the detected intensities yields the estimation of the time evolution of the effective attenuation coefficient, which is compared with the theoretically calculated values obtained for a number of combinations of tissue parameters. The experimental test of the proposed applicator and approach for freezing depth reconstruction was performed using gelatin-based tissue phantom and rat liver tissue in vivo. It revealed the ability to estimate depth up to 8 mm. The in vivo study confirmed the feasibility of the applicator to sense the freezing depth of living tissues despite the possible diversity of their optical parameters. The results justify the potential of the described design of a sapphire instrument for cryosurgery.

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Retrospective analysis of CT-guided percutaneous cryoablation for treatment of painful osteolytic bone metastasis

Cited by 9 publications

References 28 publications

Interventional Radiology in the Management of Metastases and Bone Tumors

Interventional Radiology in the Management of Metastases and Bone Tumors

CIRSE Standards of Practice on Thermal Ablation of Bone Tumours

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

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