Retrospective Analysis of Concurrent Chemoradiation with the Combination of Bleomycin, Ifosfamide and Cisplatin (BIP) for Uterine Cervical Cancer

Aoki, Michiko; Akahira, Jun Ichi; Niikura, Hitoshi; Saito, Shizuka; Abe, Y.; Aida, Taku Michael; Sato, Naoko; Kitamura, Taro; Otsuki, Kenro; Katahira, A.; Utsunomiya, Hiroki; Okamura, Chikako; Takano, Tadao; Itō, Kiyoshi; Okamura, Koji; Yaegashi, Nobuo

doi:10.1620/tjem.204.309

Cited by 2 publications

(2 citation statements)

References 40 publications

(30 reference statements)

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“…S-1 is an oral anticancer drug composed of tegafur, gimeracil, and oteracil in a molar ratio of 1:0.4:1. [3] Among the agents used to treat ARCC (paclitaxel, [4,5] topotecan, [6,7] irinotecan, [8,9] vinorelbine, [10] capecitabine, [11,12] ifosfamide, [13,14] and S-1), [15,16] S-1 is amongst the most active, with an overall response rate (ORR) of 36.6% and a median survival time following S-1 treatment of 15.4 months. [17] Although encouraging, these findings were obtained in a study that only included patients with no or one prior chemotherapy treatment; consequently, 48.3% of the patients in the study received S-1 in the initial stages of ARCC.…”

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confidence: 99%

A pilot study of oral S-1 for treating heavily pretreated patients with advanced or recurrent cervical cancer among Chinese population

Liu

Zhang

et al. 2018

Medicine

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This pilot study retrospectively aimed to assess the feasibility effectiveness and safety of oral S-1 in heavily pretreated patients with advanced or recurrent cervical cancer (ARCC) among Chinese population.Thirty patients with ARCC who had undergone one or more lines of chemotherapy received oral S-1 (40-60 mg/m) twice daily for 6 weeks. Outcome measurements included tumor response, time to progression (TTP), overall survival (OS) time, and occurrence of adverse events (AEs).The overall response rate was 43.3%. After a median follow-up of 6 months, the median TTP was 4.4 months and the median OS time was 10.2 months. The most frequent grade 3 or 4 AEs were neutropenia (13.3%) and nausea (16.7%).The results of this study show that oral S-1 is effective and well-tolerated in patients with ARCC who were heavily pretreated among Chinese population.

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Section: Introductionmentioning

confidence: 99%

A pilot study of oral S-1 for treating heavily pretreated patients with advanced or recurrent cervical cancer among Chinese population

Liu

Zhang

et al. 2018

Medicine

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“…Uterine cervical carcinoma is the second leading cause of death from gynecological malignances in the majority of developed countries, and is the main cause of cancer mortality in less developed countries. In Japan, the incidence of cervical carcinoma has been reported to be more than 6500 cases annually (Aoki et al, 2004). Apoptosis, a form of cell death, is programmed cell death which occurs in several pathological situations in many organisms (DeLong, 1998), and is characterized by a series of conserved steps.…”

Section: Discussionmentioning

confidence: 99%

Pinelliae Rhizoma Herbal-Acupuncture Solution Induced Apoptosis in Human Cervical Cancer Cells, SNU-17

2006

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Pinelliae Rhizoma has been used traditionally in Korea to promote the liver Qi activity and the function of the digestive system. We investigated whether the Pinelliae Rhizoma herbal-acupuncture solution (PRHS) would induce cell-death on SNU-17, human cervical cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to investigate the cytotoxicity of PRHS. The cell death was identified as apoptosis with 4, 6-diamidineo-2-phenylindole (DAPI) staining, and terminal deoxy-nucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. PRHS could induce apoptosis of SNU-17 via Bax-related caspase-3 activation. The expressions of both Bax, a pro-apoptotic gene, and caspase-3, an apoptotic gene, were increased. The results might provide the experimental data for the clinical use of Pinelliae Rhizoma on cervical cancer.

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Retrospective Analysis of Concurrent Chemoradiation with the Combination of Bleomycin, Ifosfamide and Cisplatin (BIP) for Uterine Cervical Cancer

Cited by 2 publications

References 40 publications

A pilot study of oral S-1 for treating heavily pretreated patients with advanced or recurrent cervical cancer among Chinese population

A pilot study of oral S-1 for treating heavily pretreated patients with advanced or recurrent cervical cancer among Chinese population

Pinelliae Rhizoma Herbal-Acupuncture Solution Induced Apoptosis in Human Cervical Cancer Cells, SNU-17

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