Retrospective Analysis of Blood Transfusion Recipients: Evidence for Post‐Transfusion Hepatitis E

Arankalle, V. A.; Chobe, L. P.

doi:10.1046/j.1423-0410.2000.7920072.x

Cited by 115 publications

(87 citation statements)

References 8 publications

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“…This disagrees with the report of Junaid et al [6] who recorded a strong association of HEV IgM with history of blood transfusion, but not with IgG. Although, there is no strong evidence that HEV is being transmitted through blood transfusion or blood products [17].…”

Section: Discussioncontrasting

confidence: 76%

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Oloke

2017

JHVRV

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This study was undertaken to determine the seroprevalence, and associated risk factors, of hepatitis E virus. A total of 186 consented apparently healthy individuals were recruited. Interviewer-administered questionnaire was used to obtain the socio-demographic information from the individuals. Blood samples were collected and analyzed for anti-HEV using third generation enzyme-linked immunosorbent assay (ELISA). Samples were collected over a period of 10 months (December 2014 -September 2015. Results obtained were analyzed using Statistical Package for Social Sciences (SPSS) version 20.0 statistical software; Chi-square (χ 2 ) test was utilized to assess the association between the sociodemographic variables and HEV status while Logistic regression was done to determine the strength of association between the potential risk factors and HEV status (statistical significance was set at P ˂ 0.05). The overall anti-HEV prevalence was 2.7% (5/186). The highest seroprevalence was in the age range 15-25 (4.1%) years. Males had higher prevalence (3.2%). None of the sociodemographic status and potential risk factors were significantly associated with HEV infection (P ˃ 0.05). Preventive public health measures should be maintained among individuals and communities. Data suggest further research with larger population as HEV remains an under-recognized public health challenge.

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Section: Discussioncontrasting

confidence: 76%

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Oloke

2017

JHVRV

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“…Transmission occurs mainly by faeco-oral route; however recent reports indicate a significant transmission by blood borne route [4][5][6][7]. In a study carried out in India 1.5% of voluntary blood donors screened for HEV were positive for HEV RNA.…”

Section: H Epatitis E Virus (Hev) Is a Common Infection Inmentioning

confidence: 98%

“…However, a highly significant proportion (76%) of paid plasma donors were positive for immunoglobulin G (IgG) antibodies to HEV indicating a possible role of blood derived HEV in transmission of virus among plasma donors [4]. In a retrospective analysis of blood transfusion recipients approximately 5% individuals acquired fresh HEV infection following transfusion [5]. Blood borne transfusion is more common in patients who have received multiple transfusions and there are reports to indicate that these patients are more likely to have icteric disease and higher serum alanine amino transferase levels , however exact natural history of post transfusion Hepatitis E is still not fully elucidated [7,8].…”

Section: H Epatitis E Virus (Hev) Is a Common Infection Inmentioning

confidence: 99%

Incidence of Hepatitis E Virus Infection in Recipients of Blood or Blood Products Transfusion

Anand¹,

Singh

Sharma

et al. 2010

Medical Journal Armed Forces India

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Background: Hepatitis E, generally known to be transmitted faeco-orally, has been shown to have significant transmission by blood borne route. Paucity of data on asymptomatic viremia in blood donors and higher incidence of Hepatitis E in haemodialysis patients and thalassemics mandate a prospective study of blood recipients to elucidate the exact incidence and natural history of post transfusion Hepatitis E. Methods: A total of 2000 recipients of blood or blood products transfusion were followed up for two months to detect development of post transfusion Hepatitis E, by clinical examination, transaminases and immunoglobulin M anti hepatitis E virus (IgM anti HEV). Estimation of hepatitis E virus ribonucleic acid (HEV RNA) was done in patients with elevated levels of transaminases. Result: Out of 2000 patients, 5(0.25%) were positive for IgM anti HEV at the time of transfusion and were excluded from the study. Rest of 1995 patients were followed up for two months post transfusion. A total of 1303 (65.3%) patients were followed up for two months and 1636 (82.0%) patients at least once in two visits. None of the followed up patients reported development of jaundice or had clinically evident hepatitis, although 62 patients had raised transaminases detected at either one or both the visits. Conclusion: All followed up patients were tested for IgM anti HEV at both the visits and none were found to be positive. Patients with raised transaminases were subjected to HEV RNA and all were found to be negative. MJAFI 2010; 66 : 204-207

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“…Retrospektive Untersuchungen in Regionen, in denen HEV endemisch ist, lassen vermuten, dass HEV durch Bluttransfusionen übertragen wurde [180,217]. Über transfusionsassoziierte HEV-Übertragun-gen wurde aus Saudi-Arabien berichtet, einem Land, in dem HEV-1 endemisch ist [181].…”

Section: üBertragbarkeitunclassified

Hepatitis-E-Virus

Gesundheit¹

2015

Bundesgesundheitsbl.

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Retrospective Analysis of Blood Transfusion Recipients: Evidence for Post‐Transfusion Hepatitis E

Abstract: The results suggest that, in countries where HEV is endemic, the transmission of hepatitis E may be associated with blood transfusion.

Cited by 115 publications

References 8 publications

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Incidence of Hepatitis E Virus Infection in Recipients of Blood or Blood Products Transfusion

Hepatitis-E-Virus

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