Retrospective analysis of adverse drug reactions induced by gemcitabine treatment in patients with non-small cell lung cancer

Retrospective evaluation of adverse drug reactions induced by antihypertensive treatment

“…In agreement with the previous studies,[456711] we have detected the highest percentage of ADRs in patients >61 years, who have also been receiving multiple therapies. This high percentage is probably underestimated, because in older adults it may be difficult to recognize an ADR, as it can mimic some features of their age-related disease.…”

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes

“…Bejer and de Blaey [44] reported that the proportion of admissions related to ADRs in older people was four times higher than in younger people. In addition, we documented that ADRs are more common in elderly patients than in the young [45][46][47][48]. It was recently reported that comorbidity could predict repeat admission for ADRs in older adults [49].…”

Enhanced antitumor efficacy of gemcitabine-loaded temperature-sensitive liposome by hyperthermia in tumor-bearing mice

“…Gemcitabine (2 0 2 0 -difluoro-2 0 -deoxycytidine) is an analog of cytosine arabinoside that shows a good antitumor activity in a variety of solid tumors, including experimental solid tumor, nonsmall-cell lung cancer, ovarian, head and neck, and pancreatic carcinomas [20][21][22][23][24] . Gemcitabine is metabolized intracellularly by nucleotide kinases to active diphosphate and triphosphate nucleosides, and the cytotoxic effect of this drug is attributed to a combination of the actions of these nucleosides, which inhibit DNA synthesis and cell proliferation 24 .…”