2018
DOI: 10.1111/ijd.14143
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Retrospective analysis of a single‐center clinical experience toward development of curative treatment of 123 pemphigus patients with a long‐term follow‐up: efficacy and safety of the multidrug protocol combining intravenous immunoglobulin with the cytotoxic immunosuppressor and mitochondrion‐protecting drugs

Abstract: While the individualized therapeutic approaches to eradicate the autoreactive B cell clones causing disease in each particular PV or PF patient are being developed, all pemphigus patients can benefit from the treatment protocol described in this study.

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Cited by 24 publications
(22 citation statements)
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“…First, we determined whether serum levels of these non-Dsg AuAb species correlate with the Pemphigus Disease Area and Activity Index (PDAAI) in the Dsg1/3 AuAb-negative acute PV patients ( Table 1). All patients were treated by our original multidrug protocol described elsewhere (17), and their serum samples were obtained prior to treatment and right after they reached complete remission (i.e. complete healing of erosions with or without secondary skin changes in the absence of new lesions and with negative Nikolskiy sign (i.e.…”
Section: Evaluation Of Auabs To Specific Non-dsg Antigens In Sera Of mentioning
confidence: 99%
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“…First, we determined whether serum levels of these non-Dsg AuAb species correlate with the Pemphigus Disease Area and Activity Index (PDAAI) in the Dsg1/3 AuAb-negative acute PV patients ( Table 1). All patients were treated by our original multidrug protocol described elsewhere (17), and their serum samples were obtained prior to treatment and right after they reached complete remission (i.e. complete healing of erosions with or without secondary skin changes in the absence of new lesions and with negative Nikolskiy sign (i.e.…”
Section: Evaluation Of Auabs To Specific Non-dsg Antigens In Sera Of mentioning
confidence: 99%
“…The mucosal type of PV was diagnosed in seven patients, and the mucocutaneous type was diagnosed in five patients. Prior to initiation of treatment of our Dsg1/3 AuAb-negative acute PV patients with the multidrug protocol detailed elsewhere (17), the mean duration of the disease was 1.6 years. The titer of "intercellular" antibodies determined on monkey esophagus ranged from 1/320 to 1/5120.…”
Section: Pemphigus Seramentioning
confidence: 99%
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“…While these therapies have become more accepted as a standard of care, corticosteroids are still generally required for prolonged periods of time for acute disease . Likewise, relapses are common, especially in shorter treatment protocols, rather than protracted protocols . As such, improved treatment targets are still desperately needed.…”
Section: Introductionmentioning
confidence: 99%
“…[42][43][44][45][46][47][48] Likewise, relapses are common, especially in shorter treatment protocols, rather than protracted protocols. 36,[49][50][51][52][53] As such, improved treatment targets are still desperately needed.…”
Section: Introductionmentioning
confidence: 99%