Retrospective analysis of 74 cases of seminoma treated with radiotherapy

Abstract

Background : Standard post-orchiectomy radiotherapy (RT) is accepted as a standard management option for stage I seminoma. Methods : Retrospective evaluation of 74 patients with stage I seminoma was performed according to the Royal Marsden staging system. All of the patients underwent RT in the Radiation Oncology Department of Gülhane Military Medical Academy between 1974 and 1995. The median age of patients was 27 years (range, 20-56). Radiotherapy was applied to all of the patients after orchiectomy for adjuvant purposes. Sixty-nine patients underwent RT while five patients who had recurrence received chemotherapy following radiotherapy. Results : After a mean follow-up period of 54 months, the 5-year overall survival rate was 98.61%, which complied with the literature. The disease-free survival rate was 90.54%. According to the World Health Organization toxicity scale, acute enteritis was 9.4% for grade I and 5.4% for grade II, while nausea/vomiting was 36.4% for grade I and 5.4% for grade II. Conclusion : To avoid acute toxicity related to RT, prognostic risk factors should be well-known and patients with low risk factors should be monitored carefully after orchiectomy. RT should be directed to the para-aortic ± ipsilateral pelvic lymph nodes in high risk patients. Although post-orchiectomy RT is a traditional management option for clinical stage I seminoma, the results of RT should be well-known to compare it with other treatment options (e.g. RPLND, adjuvant chemotherapy and surveillance).

Testicular myeloid sarcoma: a relapse of acute myeloid leukaemia after allogeneic peripheral blood stem cell transplantation- a rare presentation

“…Seminoma may also be considered as it is the most commonly encountered tumour in the testis 24. However, the lack of PAS immunoreactivity and the absence of clear and vacuolated cytoplasm excluded the possibility of seminoma 25 26…”

Sodium Iodide Symporter Protein Expression and Clinicopathological Variables in Pure Testicular Seminomas

“…Although seminomas are usually early-stage tumors and curable with standard treatments, chemotherapy after surgery is preferred for non-seminomatous tumors. Güden et al (12) reported that five-year survival and five-year disease-free survival rates were 98.6% and 90.54%, respectively, in 74 stage I seminomas. According to the World Health Organization toxicity scale, grade I and II enteritis were reported as 9.4% and 5.4% while grade I and II nausea and vomiting were observed in 36.4% and 5.4% of the patients, respectively (12).…”

“…Güden et al (12) reported that five-year survival and five-year disease-free survival rates were 98.6% and 90.54%, respectively, in 74 stage I seminomas. According to the World Health Organization toxicity scale, grade I and II enteritis were reported as 9.4% and 5.4% while grade I and II nausea and vomiting were observed in 36.4% and 5.4% of the patients, respectively (12). Radioiodine treatment is worth investigating as an alternative therapy for treatment-resistant tumors or for patients who cannot have radiotherapy or chemotherapy because of severe side effects.…”