Retrospective analysis of 268 cases of Amniocentesis and Chorion Villus Sampling

Abstract

Objective: Invasive prenatal tests have still been important and indispensable. We aimed to share the indications, results and complications of our amniocentesis and chorion villus sampling cases from Gaziantep Gynecology and Maternity Hospital.Methods: Data from 253 amniocentesis and 15 chorion villus sampling procedures between 2010-1011 have been analyzed retrospectively.Results: Genetic abnormality was detected in 6.8% of amniocentesis (n=17) and 26.6% of chorion villus sampling cases (n=4). 3.2% of the chromosomal abnormalities were numerical (n=8) and the most common of it was trizomy 21 (2.8%, n=7). Total fetal loss was 0.7% (n=2). Conclusion:The similarity of genetic abnormality and complication rates with the literature is encouraging for the educated and experienced staff to perform invasive procedures in the hospitals except university and education hospitals.

Van ve Çevresinde Bulunan Türkiye’nin Doğu İllerindeki Prenatal Genetik Test Sonuçları

“…Trisomy 21 was the most common numerical chromosomal anomaly followed by trisomy 18, trisomy 13, triploidy, Turner Syndrome and trisomy 14. Daglar et al (17) showed that the chromosomal anomaly rate was 26.6% in CVS cases and 20% of them had numerical anomaly. In the study by Bilen et al (12) in 42 CVS cases, chromosomal anomaly rate was reported as 35.7%, and the most common anomaly was trisomy 21 in 53.5% of the cases.…”

“…In our study, maternal age over 35 was present in 12 of 58 patients who underwent CVS, but in these patients there were increased risk in the first trimester screening test or abnormal USG findings as well. Dağlar et al (17) showed that increased risk of first trimester combined test (80%) was the most common CVS indication followed by advanced maternal age (13.3%). On the other hand, in a study of Oztas et al (18) in the 354 patients who were performed CVS, increased risk of combined screening test (68.6%) was the most common indication for the procedure; followed by the increase in NT (19.2%).…”