Retropubic radical prostatectomy: Clinicopathological observations and outcome analysis of 428 consecutive patients

Abstract

Aim:We report the outcome analysis of retropubic radical prostatectomy (RRP) performed in 428 patients in terms of pathological findings, complications, and survival.Materials and Methods:Systematically recorded case reports forms of consecutive 428 RRPs done over a 14-year period were analyzed using the SPSS 14 software. Secondary analysis was done to evaluate era specific (pre and post 2002) changes in clinical features and survivals.Results:Seven-year overall survival (OAS), cancer-specific survival (CSS), and event-free survival (EFS) was 83.2%, 82.8%, and 69.8% respectively in our series. Era-specific survival showed higher CSS post 2002, and there was an increase in presentation with organ-confined disease. Univariate and multivariate analysis showed statistically significant impact on era specific outcome. With the improvement in techniques decrease in complications rate and increase in quality of life was noted.Conclusions:Our series spanning over decade demonstrates that RRP is viable option to offer cure to organ-confined carcinoma prostate. Further, there is evidence of stage migration and improvements in outcome in post 2002 patients. Although our series is modest in number, the success rates and outcome data matches those reported in the literature.

Impact of Gleason pattern up gradation after radical prostatectomy for carcinoma prostate patients with low biopsy score (≤ 6)

“…[5] From the same cohort of 428 patients, 257 had biopsy Gleason score (b GS≤ 6) ranging from 2 to 6, and analysis of these patients forms the basis of the report. As described in the "results" section, we found 41.2% patients had upgradation after analysis of RP specimen in our series.…”

Pathological outcomes and biochemical recurrence-free survival after radical prostatectomy for high-risk prostate cancer in the Indian population

“…[ 1 ] Increasing availability of prostate-specific antigen (PSA) testing and prostate biopsy may have resulted in an increased diagnosis of CaP, but many patients still present with locally advanced disease or metastases in our country. [ 2 3 ]…”

Development of an Indian nomogram for predicting extracapsular extension in prostate cancer

“…[ 15 ] In our study, we have considered wEPE; hence, ECE rates are high, and these rates are consistent with data from other centers from India and Europe. [ 2 23 26 ]…”

“…Carcinoma prostate (PCa) is the second most common cancer in men in India, and a large number of patients are diagnosed at a locally advanced stage unlike in other developed countries. [ 1 2 3 ] Guidelines emphasize radical prostatectomy (RP) or, more recently, nerve-sparing radical prostatectomy (NSRP) as the surgery of choice for patients with localized disease, age less than 65 years, and with a mean life expectancy of at least 10 years, for better functional and oncological outcomes. [ 4 5 ] PCa with extracapsular extension (ECE) is associated with decreased overall and cancer-specific survival following RP compared to organ-confined disease.…”