Retroperitoneal Spindle Cell Tumor: A Case Report

Hao, Hua; He, Zhiwei; Lei, Linhan; Xie, Huimin; Deng, Zilei; Cheng, Zili; Zuo, Shi; Sun, Chaoli; Chao, Yu Hua

doi:10.3389/fsurg.2021.764901

Cited by 6 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These types of lesions are histologically characterized by a mixture of fibroblast-like spindle cells and sometimes fat cells in the field of myxoid, mucoid, or collagenous materials that can be tracked in different soft tissue organs such as the nervous system, gastrointestinal tract, breast, mesenchymal tissues, and even exocrine and endocrine glands [ 5 ]. Some rare patterns of these lesions have also been revealed in bony structures as well as in retroperitoneal space [ 6 , 7 ]. Due to its rarity, a few studies have been performed on its clinical and pathological behaviors.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Abbaszadeh,

Naderi,

Jalali

et al. 2024

Case Reports in Pediatrics

View full text Add to dashboard Cite

Introduction: Different subtypes of cardiac tumors containing spindle cells have been described as cardiac sarcoma. However, benign types have not been reported so far. We described a neonate with progressive respiratory distress who had a PDA and was finally diagnosed with a right atrial spindle cell tumor. Case Presentation: The patient was a neonate referred with respiratory distress and sepsis. The initial echocardiography demonstrated a small atrial septal defect, patent ductus arteriosus, and a heterogeneous rounded right atrial mass lesion. Pathologic examination confirmed the right atrial myxoid spindle cell tumor without local invasion. Successful mass resection was performed, and follow‐up echocardiography revealed normal cardiac structure and function. Conclusion: In infants with manifestations of possible cardiac anomalies, it is necessary to consider other pathologies, such as neoplastic processes. Spindle cell detection in pathology is not ominous all the time, and there are benign subtypes with favorable outcomes after successful surgical resection.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Abbaszadeh,

Naderi,

Jalali

et al. 2024

Case Reports in Pediatrics

View full text Add to dashboard Cite

show abstract

“…The management of limb spindle cell sarcomas requires a comprehensive approach that considers the tumor’s behavior[ 8 ], individual patient factors, and the potential risks and benefits of various treatment options. Surgery is typically the primary treatment option[ 9 ]. Aggressive management is necessary for regional and distant metastases.…”

Section: Discussionmentioning

confidence: 99%

Managing spindle cell sarcoma with surgery and high-intensity focused ultrasound: A case report

Zhu,

Zhao,

Zheng

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

show abstract

“…However, most cases belong to the intermediate group and are difficult to classify, and malignant transformation of benign tumors is often encountered [10]. Spindle cell tumors are derived from various types of tumors such as fibrosarcoma, gastrointestinal stromal tumors, and intra-abdominal desmoid tumors [11], and in malignant cases, carcinoma, an epithelial malignancy, and sarcoma, a stromal malignancy, are found within the same tumor [12,13]. No common view of the histological features has been established in the stromal area, which is mainly composed of spindle-shaped cells that constitute the sarcoma-like component [14].…”

Section: Discussionmentioning

confidence: 99%

“…Although the imaging characteristics of spindle cell tumors have not been established [22] and differential diagnosis is generally difficult [23], a needle biopsy may be considered as an aid in improving preoperative diagnosis. However, it should be noted that the accuracy rate of the preoperative diagnosis is not high [24,25] and may be a cause of dissemination [26], so it may not be recommended aggressively.…”

Section: Discussionmentioning

confidence: 99%

Primary spindle cell tumor originating from the liver that was difficult to diagnose

Ikehara¹,

Shimizu²,

Hirano³

et al. 2022

surg case rep

View full text Add to dashboard Cite

Background It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1.8% of all HCCs, but spindle cell tumors that do not show an obvious conventional HCC are extremely rare. In this report, we describe a case of resection of a primary spindle cell tumor of the liver that was difficult to diagnose. Case presentation A 75-year-old man presented with fever and right chest pain. He was suspected of a giant primary diaphragmatic tumor of extrahepatic origin by imaging studies. The preoperative differential diagnosis included benign masses such as myxoid sarcoma and schwannoma, and we planned a diaphragmatic resection. Intraoperatively, however, dissection of the tumor from the liver was not possible, requiring an extended right posterior segmentectomy with combined resection of the diaphragm. The patient had a good postoperative course and 1 year has passed since the surgery with no recurrence. The pathology showed that the mass was located just below the hepatic capsule/parenchymal region and was adherent to the diaphragm, but there was no continuity. The morphology suggested a low-grade mesenchymal tumor such as a solitary fibrous tumor and perivascular epithelioid cell tumor, but immunostaining was negative, making the diagnosis difficult. Although some areas of high proliferative activity were observed, finally, the diagnosis of primary spindle cell tumor of the liver with smooth muscle differentiation was made based on the positive results of muscle markers such as αSMA, desmin, and h-caldesmon. Conclusions Spindle cell tumor arising from the liver is so rare that preoperative and pathological diagnosis is often difficult to reach. Although further studies are needed to elucidate and better understand this uncommon clinical entity, we consider that complete resection is necessary for the above case, which may contribute to long-term survival.

show abstract

Retroperitoneal Spindle Cell Tumor: A Case Report

Cited by 6 publications

References 16 publications

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Managing spindle cell sarcoma with surgery and high-intensity focused ultrasound: A case report

Primary spindle cell tumor originating from the liver that was difficult to diagnose

Contact Info

Product

Resources

About