Retroperitoneal sarcomas in dogs: 14 cases (1992–2002)

Liptak, Julius M.; Dernell, William S.; Ehrhart, E. J.; Rizzo, Scott A.; Rooney, Matthew B.; Withrow, Stephen J.

doi:10.2460/javma.2004.224.1471

Cited by 43 publications

(52 citation statements)

References 28 publications

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“…Es decir, perros de edad avanzada (Patnaik 1990;Kuntz et al 1998;Langenbach et al 1998;Duffy et al 2015), lo cual coincide con la edad media de presentación de 9 años (rango 2-13 años) de sarcomas retroperitoneales en un estudio (Liptak et al 2004). El paciente de este reporte tenía 15 años, al momento del diagnóstico, mayor a la edad media reportada pero aún dentro del rango de edades de los estudios mencionados.…”

Section: Discussionunclassified

“…Los signos clínicos más comunes, que presentan los pacientes con OEE, son: depresión, letargia, distensión abdominal, dificultad respiratoria, pirexia, pérdida de peso, dolor abdominal y signos gastrointestinales como, disminución del apetito, anorexia, vómito y melena (Liptak et al 2004;MacKenzie et al 2012;Timian et al 2012). La presencia de estos signos inespecíficos en pacientes con sarcomas retroperitoneales es común; sin embargo, pueden presentarse en perros con otros tumores, incluyendo neoplasias renales, hepáticas y esplénicas (Liptak et al 2004).…”

Section: Discussionunclassified

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Osteosarcoma extraesquelético retroperitoneal en un perro: reporte de un caso

Piedra-Mora¹,

Barrantes-Murillo²,

Alfaro-Alarcón³

2016

Ciencias Veterinarias

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Resumen: Se presentó un perro, de raza mixta, no castrado, 15 años de edad, con hiporexia, constipación, letargia y dolor abdominal. En el examen físico, se identificó una masa intraabdominal. Las pruebas hematológicas evidenciaron anemia leve, normocítica y normocrómica y leucocitosis a causa de neutrofilia. Los resultados de bioquímica sérica mostraron alteraciones del nitrógeno ureico sanguíneo, fosfatasa alcalina sérica y creatinina. En el ultrasonido, se detectó un nódulo en bazo. Las radiografías evidenciaron un área radiopaca en abdomen, cerca de las vértebras lumbares. Se realizó laparotomía exploratoria y se encontró dos masas retroperitoneales. Se realizó la eutanasia del paciente, debido al difícil abordaje quirúrgico. El análisis histopatológico e inmunohistoquímico de las masas fue concluyente de un osteosarcoma extraesquelético. Los osteosarcomas extraesqueléticos son tumores malignos, de origen mesenquimal infrecuentes, sin involucramiento primario de tejido óseo o periostio. La localización retroperitoneal de estos tumores pocas veces ha sido reportada.Palabras clave: osteosarcoma extraesquelético, retroperitoneo, perro. Abstract:A 15-year-old not neutered mixed-breed dog was presented with hyporexia, constipation, lethargy and abdominal pain. An intra abdominal mass was identified during the physical examination. Mild normocytic and normochromic anemia and leukocytosis due to neutrophilia were detected in the complete blood count. Serum biochemistry results showed alterations in blood urea nitrogen, serum alkaline phosphatase, and creatinine. A splenic nodule was detected during the ultrasonographic examination, and radiographic findings showed a radiopaque area in the abdomen near the lumbar vertebrae. An exploratory laparotomy was done, and two retroperitoneal masses were found. Due to the difficult surgical approach euthanasia was elected. Histopathological and immunohistochemical evaluation of tissues was performed and the diagnosis of extraskeletal osteosarcoma was made. Extraskeletal osteosarcoma is an infrequent malign mesenchymal tumor without primary involvement of bone tissue or periosteum. Seldom has the retroperitoneal localization of this tumor been reported.

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Section: Discussionunclassified

Osteosarcoma extraesquelético retroperitoneal en un perro: reporte de un caso

Piedra-Mora¹,

Barrantes-Murillo²,

Alfaro-Alarcón³

2016

Ciencias Veterinarias

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“…In these more aggressive anatomic forms, HSA advances quickly, leading to development and rupture of large tumors, bleeding episodes, early dissemination, and cardiovascular collapse related to uncontrolled visceral hemorrhage. 4,12,18 Renal HSA appears to exhibit a more insidious onset, with nonspecific clinical signs and a protracted duration of clinical signs before diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent report of retroperitoneal sarcomas (64% of which were HSA), dogs demonstrated short survival times, with a reported median survival time of 37.5 days, and 8/9 dogs with retroperitoneal HSA had metastatic disease. 18 Conversely, it is uncommon for dogs with cutaneous HSA to exhibit systemic clinical signs or evidence of advanced-stage disease at the time of presentation. In this form of HSA, clinical stage has been directly correlated to biologic behavior, as frequency of local recurrence and risk of distant metastasis significantly increased from stage I compared to stage II and III disease.…”

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confidence: 99%

Comparative Aspects and Clinical Outcomes of Canine Renal Hemangiosarcoma

Locke

Barber

2006

Veterinary Internal Medicne

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Background: Hemangiosarcoma (HSA) is a common solid tumor of the spleen, heart, and skin of dogs. Renal HSA represents an uncommon anatomic variant, with little reported about its biologic behavior and clinical outcome. Hypothesis: That renal HSA is associated with longer survival than other visceral forms of HSA. Animals: 14 dogs with renal HSA. Methods: Medical records from 1999 to 2004 were searched for dogs with histopathologically confirmed renal HSA, and data relevant to clinical signs, treatments, and outcomes were abstracted. Results: Clinical signs were nonspecific, and the median duration of clinical signs before diagnosis was 60 days. Two dogs presented in cardiovascular collapse secondary to hemoperitoneum. Common hematologic and biochemical abnormalities were anemia (9/14), hematuria (7/14), and proteinuria (7/14). One dog had pulmonary metastasis at diagnosis. All dogs had evidence of a renal mass visualized by abdominal radiography (14/14), ultrasound (9/14), or both. All dogs underwent nephrectomy, and 4/14 dogs also received adjunctive chemotherapy. Median survival time of all dogs was 278 days (range 0–1,005 days), and dogs with hemoperitoneum had significantly shorter survival times than dogs without hemoperitoneum (62 days versus 286 days, P < .001). Conclusions and Clinical Importance: These results indicate that hemoperitoneum and distant metastasis at diagnosis appear to occur less frequently in dogs with renal HSA compared with other visceral forms of HSA. Furthermore, dogs with renal HSA have protracted disease progression, with improved 1 ‐year survival rates and longer median survival time compared to dogs with splenic, cardiac, and retroperitoneal HSA.

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“…Two forms of the hemangiosarcomas i.e., visceral and dermal forms exists. In the visceral form, the most frequently affected organs were spleen and liver (Day et al, 1995;Withrow & MacEwen, 2001;Hristov et al, 2007) and rarely seen in the retroperitoneal organs like adrenal glands, kidneys and ureters (Wang & Su, 2001;Liptak et al, 2004) and uterus (Murakami et al, 2001). Whereas in dermal form, most common predilection sites are ventral abdomen, prepuce and pelvic limbs (Ward et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Histopathological features of cutaneous tumours arising from the vascular endothelial cells in dogs

Jayasree¹,

Nasreen²,

Sh³

et al. 2016

JEBAS

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Cutaneous growths arising from the endothelial cells of blood vessels were studied in three dogs (Two in male cocker spaniels and one in male Labrador). All the three growths were surgically excised and referred to the Department of Veterinary Pathology, Tirupati for histopathological confirmation during the period from August 2015 to December 2015.Gross examination revealed, firm reddish, soft dark red and soft greyish red coloured masses and are diagnosed based on histopathological features as hemangiosarcoma, cavernous hemangioma and lipohemangioma respectively. In the case of hemangiosarcoma, severe necrosis along with the presence of blastomyces organisms as a secondary infection was also noticed. Occurring of these tumours might be because of exposure of lightly pigmented areas to Ultra Violet radiation.

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Retroperitoneal sarcomas in dogs: 14 cases (1992–2002)

Abstract: In dogs, retroperitoneal sarcomas are aggressive tumors with a high rate of local recurrence and metastasis, and a poor survival time.

Cited by 43 publications

References 28 publications

Osteosarcoma extraesquelético retroperitoneal en un perro: reporte de un caso

Osteosarcoma extraesquelético retroperitoneal en un perro: reporte de un caso

Comparative Aspects and Clinical Outcomes of Canine Renal Hemangiosarcoma

Histopathological features of cutaneous tumours arising from the vascular endothelial cells in dogs

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