Retroperitoneal paraganglioma presenting as hypertension and paraparesis in young

Abstract

Paragangliomas(PGL) are rare tumours that arise from extra-adrenal paraganglia. Extra-adrenal paragangliomas account for only 5 to 10% of all paragangliomas and may present incidentally as a mass. Typical triad of fluctuating hypertension, headache, and sweating is not always present which makes the diagnosis sometimes difficult. Extraadrenal retroperitoneal PGLs are functionally active more often than previously reported and that they are readily detected by soft tissue masses closely associated with the entire length of abdominal aorta. However, no CT feature was found that was unique for PGL.1 Herein we describe the clinical, radiological and pathological features in young patient presented for hypertension and paraparesis, and later on diagnosed as malignant abdominal paraganglioma with vertebral and lymph node metastasis.

A New Series of Tungstophosphoric Acid-Polymeric Matrix Catalysts: Application in the Green Synthesis of 2-Benzazepines and Analogous Rings

“…Substrate Cycle Size Product Yields (%) a Using the best reaction conditions found for N- (3,4-dichlorobenzylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepine synthesis (N-aralkylsulfonamide, 0.5 mmol; s-trioxane, 1.5 mmol; toluene, 2 mL; catalyst, PLMTPA60/40100, 1% mmol; and 70 °C, 3 h), various benzo[c]azepines, isoquinolines, and one benzo[c]azocine were prepared. The methodology is not appropriate to prepare analogous rings of five, eight, and nine members, because of the low yield.…”

“…For comparative purposes, we studied the green parameters on the same reaction with (Figure 7b) and At the acidic catalytic site, the conjugate base of the catalyst is generated momentarily, which stabilizes the ion by forming a bifurcated hydrogen bridge to both acidic hydrogens. A transfer of a proton protonates the catalyst again, which is coordinated to the hydroxymethylsulfonamide (3). A new proton transfer forms oxonium (4) from (3).…”

“…The development of green chemistry has received great attention from researchers at the academic and industry levels, due to the need to preserve a global ecosystem [1,2]. In this context, the development of new materials that are environmentally friendly, robust, and have high-density active sites compared to the bulk catalyst has gained much interest in the field of suitable chemistry due to their catalytic properties in a large number of organic transformations [3][4][5].…”