Retroperitoneal Liposarcoma Presenting With Malignant Gastric Outlet Obstruction and Acute Pancreatitis: A Case Report

Recinos, Luisa; Mohapatra, Sonmoon; Santharaman, Aadhithyaraman; Patel, Neil; Broder, Arkady

doi:10.7759/cureus.12775

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uncommonly, patients present with obstructive symptoms of the gastrointestinal or genitourinary tract, venous return, or hemorrhage. Cases have been reported of first presentations with pancreatitis [ 39 , 40 ], ischemic colitis [ 41 ], paraneoplastic syndromes [ 42 ], as well as incidental tumors found intra-operatively. Most often, tumors are detected incidentally on imaging for an unrelated complaint.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Rarely does RPS present as a surgical emergency, but rather more indolent symptoms such as pain, bleeding, and gastrointestinal obstruction. Cases have been reported of spontaneous intraperitoneal tumor rupture with massive hemoperitoneum [ 86 ], lower gastrointestinal hemorrhage from duodenocaval fistula [ 87 ], intestinal perforation [ 88 ], gastric outlet obstruction [ 39 ], biliary obstruction and ureteric obstruction [ 89 ], among others. Overall, tumor rupture is a poor prognostic factor associated with high recurrence rate and poor survival likely related to underlying aggressive subtyping and subsequent peritoneal or systemic tumor spread.…”

Section: Management Of Primary Retroperitoneal Sarcomamentioning

confidence: 99%

See 1 more Smart Citation

Retroperitoneal Sarcoma Care in 2021

Schmitz

Nessim

2022

Cancers

View full text Add to dashboard Cite

Soft-tissue sarcomas are biologically heterogenous tumors arising from connective tissues with over 100 subtypes. Although sarcomas account for <1% of all adult malignancies, retroperitoneal sarcomas are a distinct subgroup accounting for <10% of all sarcomatous tumors. There have been considerable advancements in the understanding and treatment of retroperitoneal sarcoma in the last decade, with standard treatment consisting of upfront primary surgical resection. The evidence surrounding the addition of radiation therapy remains controversial. There remains no standard with regards to systemic therapy, including immunotherapy. Adjunctive therapy remains largely dictated by expert consensus and preferences at individual centers or participation in clinical trials. In this 2021 review, we detail the anatomical boundaries of the retroperitoneum, clinical characteristics, contemporary standard of care and well as recent advancements in retroperitoneal sarcoma care. Ongoing international collaborations are encouraged to advance our understanding of this complex disease.

show abstract

Section: Clinical Presentationmentioning

confidence: 99%

Section: Management Of Primary Retroperitoneal Sarcomamentioning

confidence: 99%

Retroperitoneal Sarcoma Care in 2021

Schmitz

Nessim

2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Sarcomas comprise only 1% of all malignancies in adults, and among the various types of soft tissue sarcomas, liposarcomas are the most common [ 2 ]. According to the World Health Organization (WHO), there are five distinct subtypes of liposarcomas distinguished based on their pathologic features: dedifferentiated liposarcoma, well-differentiated liposarcoma, pleomorphic liposarcoma, round cell liposarcoma, and myxoid liposarcoma [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Dedifferentiated Duodenal Liposarcoma With Gastric Outlet Obstruction: A Rare Small Bowel Tumor

Alvi,

Shankar

2023

Cureus

View full text Add to dashboard Cite

Liposarcoma is the most prevalent malignant soft tissue tumor and is primarily found in extremities and retroperitoneum, but its occurrence within abdominal viscera is rare. Most of these cases have been reported in the esophagus and stomach. Among liposarcomas of the gastrointestinal tract, primary duodenal liposarcomas are exceptionally rare, with only five documented cases in the literature. We describe a case of a 66-year-old female presenting with syncope, melena, and anemia. Computed tomography (CT) showed soft tissue mass involving the superior wall of the duodenum and hypo-enhancing hepatic mass. An endoscopy was performed, which revealed a duodenal mass causing gastric outlet obstruction and significant bleeding. Therefore, laparotomy was performed with extensive lysis of adhesions and gastrojejunostomy.

show abstract

Case report and literature review: Conversion surgery for initially unresectable huge retroperitoneal liposarcoma after preoperative radiotherapy

et al. 2023

View full text Add to dashboard Cite

BackgroundRetroperitoneal liposarcoma (RPLS) is a rare malignancy that is notorious for recurrence. Surgical resection with clean margin is the current treatment of choice. However, owing to the large retroperitoneal space, RPLSs often grow to significant sizes before being diagnosed. Neoadjuvant and adjuvant therapies have potentials to improve long term treatment outcome.Case presentationA 55-year-old Han Chinese male presented to the general surgery department with a one-year history of abdominal fullness and a one-week history of palpable right inguinal mass. At first, he was diagnosed with incarcerated inguinal hernia. However, abdominal computer tomography (CT) and biopsy confirmed his final diagnosis to be retroperitoneal well-differentiated liposarcoma, cT2bN0M0, stage IIb. The tumor, which measured 44.5cm in maximum diameter, was too large for primary surgical resection. Neoadjuvant radiotherapy with 70 Gy in 35 fractions was delivered to the tumor, which shrunk the target volume from 6300 cc to 4800 cc, as observed in the middle of the radiotherapy course. The right testicular mass also received 70Gy/35Fx. Conversion surgery was performed after radiotherapy. Unfortunately, due to residual tumor, adjuvant chemotherapy consisting of AIM (ifosfamide, Mesna, and doxorubicin) and MAID (Mesna, doxorubincin, ifosfamide, and dacarbazine) regimens were administered sequentially. Afterward, debulking surgery was conducted, plus another 18 cycles of ifosfamide monotherapy when residual tumor was still seen on CT. Since the completion of ifosfamide chemotherapy, the patient has been cancer free with no evidence of tumor recurrence for more than 26 months.ConclusionDespite conflicting evidence in the literature, our case supports the use of high dose neoadjuvant radiotherapy and adjuvant chemotherapy in treating large, unresectable RPLSs. It also highlights the importance of using individualized, multidisciplinary approach in achieving cure for large, unresectable rare tumors.

show abstract

Retroperitoneal Liposarcoma Presenting With Malignant Gastric Outlet Obstruction and Acute Pancreatitis: A Case Report

Cited by 3 publications

References 14 publications

Retroperitoneal Sarcoma Care in 2021

Retroperitoneal Sarcoma Care in 2021

Primary Dedifferentiated Duodenal Liposarcoma With Gastric Outlet Obstruction: A Rare Small Bowel Tumor

Case report and literature review: Conversion surgery for initially unresectable huge retroperitoneal liposarcoma after preoperative radiotherapy

Contact Info

Product

Resources

About