Retroperitoneal ganglioneuroma: Report of a case diagnosed by fine-needle aspiration cytology, with review of the literature

Jain, Manjula; Shubha, B. S.; Sethi, Seema; Banga, Vineet; Bagga, Deepak

doi:10.1002/(sici)1097-0339(199909)21:3<194::aid-dc9>3.0.co;2-b

Cited by 59 publications

(45 citation statements)

References 10 publications

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“…Furthermore, these tumors are capable of excreting a wide variety of neuropeptides, and clinical presentation with signs and symptoms owing to hormone excess including hypertension, diarrhea and sweating is infrequent (2,13). Despite the availability of different non-invasive radiologic modalities e.g., CT scans and MRI scans, a definitive pathological diagnosis of these tumors is dependent on the post-operative histopathological findings and in certain instances pre-operative image-guided biopsies (6,14,15).…”

Section: Discussionmentioning

confidence: 99%

“…GN can be diagnosed de novo in healthy patients or in specific cases result from spontaneous or chemo-or radiotherapy induced maturation of less-differentiated neuroblastic tumors (neuroblastoma and ganglioneuroblastoma) (1,5). In addition, certain studies have presented an association between GNs and specific familial diseases including neurofibromatosis type 2 and multiple endocrine neoplasia type 2 (6,7). While GNs can occur anywhere along the sympathetic nervous system, the two most common locations of occurrence are the posterior mediastinum and retroperitoneum (6).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, certain studies have presented an association between GNs and specific familial diseases including neurofibromatosis type 2 and multiple endocrine neoplasia type 2 (6,7). While GNs can occur anywhere along the sympathetic nervous system, the two most common locations of occurrence are the posterior mediastinum and retroperitoneum (6). Retroperitoneal tumors may originate from the adrenal glands or extra-adrenal tissues (6).…”

Section: Introductionmentioning

confidence: 99%

“…While GNs can occur anywhere along the sympathetic nervous system, the two most common locations of occurrence are the posterior mediastinum and retroperitoneum (6). Retroperitoneal tumors may originate from the adrenal glands or extra-adrenal tissues (6). There are a limited number of studies reporting tumor occurrence in uncommon locations, including the tongue, bladder, uterus and skin (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Ex vivo excision of retroperitoneal soft tissue tumors: A case report

Rahnemai‐Azar¹,

Griesemer²,

Velasco³

et al. 2017

Oncology Letters

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Abstract. Ganglioneuromas are slow growing, clinically silent benign tumors for which surgery is considered to be the standard treatment. However, surgical excision in cases where surrounding structures are involved can be challenging. The present study reports a novel technique of ex vivo excision for the management of a retroperitoneal ganglioneuroma in a 21-year old patient, that appeared to be inoperable using standard surgical resection. Preoperative investigations revealed a large tumor with encasement of the origins of the superior mesenteric artery (SMA) and bilateral renal arteries. Initially, to prevent the need to explant the liver, the distal SMA (with takeoff of the replaced common hepatic artery) was anastomosed to the splenic artery. The bulk of the tumor along with the bilateral kidneys was mobilized from the retroperitoneum, and the aorta and inferior vena cava (IVC) were cross-clamped above and below the tumor and divided. The two kidneys were dissected free of the tumor at the back-table and were auto-transplanted in a standard technique following the reconstruction of the aorta and IVC. The patient tolerated surgery well and a one-year postoperative follow-up did not show any sign of tumor recurrence. Although technically demanding, ex vivo resection and auto-transplantation of the involved organs can be introduced as a final option for the treatment of tumors that are un-resectable using standard surgical techniques. IntroductionGanglioneuromas (GNs) are rare, slow-growing benign tumors arising from the sympatho-adrenal neuroendocrine system (1,2). GNs typically occur in children and adolescents, with up to 60% of patients <20 years old at the time of diagnosis. Additionally, females are more likely to be affected than males (3). GNs are the benign ends of a wide spectrum of peripheral neuroblastic tumors, which also include neuroblastoma, ganglioneuroblastoma and ganglioneuroblastoma intermixed (2,4). GN can be diagnosed de novo in healthy patients or in specific cases result from spontaneous or chemo-or radiotherapy induced maturation of less-differentiated neuroblastic tumors (neuroblastoma and ganglioneuroblastoma) (1,5). In addition, certain studies have presented an association between GNs and specific familial diseases including neurofibromatosis type 2 and multiple endocrine neoplasia type 2 (6,7). While GNs can occur anywhere along the sympathetic nervous system, the two most common locations of occurrence are the posterior mediastinum and retroperitoneum (6). Retroperitoneal tumors may originate from the adrenal glands or extra-adrenal tissues (6). There are a limited number of studies reporting tumor occurrence in uncommon locations, including the tongue, bladder, uterus and skin (8-10).Although complete surgical excision is considered to be the treatment of choice in the management of these tumors, occasionally it can be challenging and in specific cases (such as when large tumors are involving the surrounding vital organs) it is not a feasible option. The current case report pre...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ex vivo excision of retroperitoneal soft tissue tumors: A case report

Rahnemai‐Azar¹,

Griesemer²,

Velasco³

et al. 2017

Oncology Letters

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“…66,88 Ganglioneuromas predominantly arise within the posterior mediastinum and retroperitoneum. 66,89 They are well-circumscribed tumors with a fibrous capsule, and cut sections are gray to yellow with a whorled-like pattern similar to leiomyoma. 66 Histologically, this tumor consists of Schwann cells with scattered deposits of ganglion cells, isolated, or small clusters.…”

Section: Neurogenic Tumorsmentioning

confidence: 99%

Practical Issues for Retroperitoneal Sarcoma

et al. 2016

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Fine‐needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: Case report

Sarode

Castellani

Post

2002

Diagnostic Cytopathology

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We report a case of fibrolamellar hepatocellular carcinoma (FL-HCC) that metastasized to the posterior mediastinum. The diagnosis was made on fine-needle aspiration biopsy (FNAB). The cytologic features were characterized by the presence of large, dishesive, polygonal cells with granular cytoplasm and well-defined cell outlines resembling oncocytes. Groups of neoplastic hepatocytes containing bile pigment were also noted. The diagnosis of FL-HCC in a metastatic site can pose diagnostic challenges on FNAB. The cytologic features overlap with a variety of tumors that have oncocytic features and also with melanoma and paraganglioma. Recognition of specific cytologic features of FL-HCC can facilitate accurate diagnosis in a metastatic site. The cytologic findings and differential diagnoses of FL-HCC that metastasized to the posterior mediastinum are discussed.

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Retroperitoneal ganglioneuroma: Report of a case diagnosed by fine-needle aspiration cytology, with review of the literature

Cited by 59 publications

References 10 publications

Ex vivo excision of retroperitoneal soft tissue tumors: A case report

Ex vivo excision of retroperitoneal soft tissue tumors: A case report

Practical Issues for Retroperitoneal Sarcoma

Fine‐needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: Case report

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