Retroperitoneal Ganglioneuroma: A Case Report and Review of the Japanese Literature.

Moriwaki, Yuji; Miyake, Mitsutomi; Yamamoto, Tetsuya; Tsuchida, Tetsuo; Takahashi, Sumio; Hada, Toshikazu; Nishigami, Takashi; Higashino, Kazuya

doi:10.2169/internalmedicine.31.82

Cited by 47 publications

(44 citation statements)

References 6 publications

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“…The posterior mediastinum accounts for 39±43 % of the cases, neck and pelvis for 8±9 % [4,5]. Ganglioneuromas represent 0.7±1.6 % of all primary retroperitoneal tumors [6]. All ages are encountered, with a predominance in children and young adults (42±60 %) [2,5,6].…”

Section: Discussionmentioning

confidence: 99%

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Imaging of retroperitoneal ganglioneuroma

et al. 2001

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The aim of this study was to describe the radiological appearance of retroperitoneal ganglioneuroma. We retrospectively reviewed seven cases of histologically proven retroperitoneal ganglioneuroma. Ultrasound and enhanced CT were obtained in all cases, and MRI in three cases. The masses were well-circumscribed, ranged in size from 5 x 3 x 3 to 10 x 6 x 4 cm. In three cases close relationships between the tumor mass and major blood vessels were noted, resulting in vessel displacement or surrounding, but without compression or occlusion. On ultrasound examination the tumor showed a heterogeneous solid echostructure. Non-enhanced CT showed homogeneous or mildly heterogeneous low attenuation, and a punctate calcification was seen in one case. Contrast uptake was absent (n = 1) or delayed (n = 6). Progressive but incomplete enhancement was observed in three cases. On MRI, T2-weighted images showed a high signal intensity. Dynamic studies depicted the same enhancement pattern as described on CT. Ganglioneuroma is a rare tumor which should nevertheless be included in differential diagnosis of retroperitoneal masses when presenting as a well-delimited tumor with possible tendency to surround or displace major blood vessels, low density on non-enhanced CT, and delayed progressive enhancement on CT and MRI.

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Section: Discussionmentioning

confidence: 99%

“…Ganglioneuromas represent 0.7±1.6 % of all primary retroperitoneal tumors [6]. All ages are encountered, with a predominance in children and young adults (42±60 %) [2,5,6]. Nevertheless, the adrenal location is encountered in patients older than 40 years [7,8].…”

Section: Discussionmentioning

confidence: 99%

Imaging of retroperitoneal ganglioneuroma

et al. 2001

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“…As it is a slow growing tumor, gross total surgical removal with preservation of organ functions is a feasible surgical option. 2,3 In conclusion the ganglioneuroma arises from sympathetic ganglion which is a very rare disease and affects children more often than adults. 1 It is a benign, slow growing tumor and since it is difficult to distinguish from other tumors due to lack of image findings diagnosis is always made histologically.…”

Section: Discussionmentioning

confidence: 97%

“…1 Ganglioneuromas may occur spontaneously or during the therapy for neuroblastomas with either chemotherapy or radiation therapy. 2,3 The reported incidence of ganglioneuroma is one per million population.…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroma: A Rare Neural Crest Tumor

Ingale¹,

Goyal²,

Mohaniya³

et al. 2015

jemds

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Neuroblastoma, ganglioneuroblastoma and ganglioneuroma arise from sympathetic tissue in the neck, posterior mediastinum, adrenal gland, retroperitoneum and pelvis. Ganglioneuromas is a rare type of neural crest tumor which are commonly seen in childhood. They are highly differentiated benign tumors and are compatible with long-term disease free survival. Retroperitoneal localization is relatively frequent for these tumors. Due to its rarity and lack of specific radiological findings diagnosis is always postoperative. Here, we present a case of retroperitoneal ganglioneuroma which was diagnosed post operatively.

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“…GNs typically occur in children and adolescents, with up to 60% of patients <20 years old at the time of diagnosis. Additionally, females are more likely to be affected than males (3). GNs are the benign ends of a wide spectrum of peripheral neuroblastic tumors, which also include neuroblastoma, ganglioneuroblastoma and ganglioneuroblastoma intermixed (2,4).…”

Section: Introductionmentioning

confidence: 99%

Ex vivo excision of retroperitoneal soft tissue tumors: A case report

Rahnemai‐Azar¹,

Griesemer²,

Velasco³

et al. 2017

Oncology Letters

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Abstract. Ganglioneuromas are slow growing, clinically silent benign tumors for which surgery is considered to be the standard treatment. However, surgical excision in cases where surrounding structures are involved can be challenging. The present study reports a novel technique of ex vivo excision for the management of a retroperitoneal ganglioneuroma in a 21-year old patient, that appeared to be inoperable using standard surgical resection. Preoperative investigations revealed a large tumor with encasement of the origins of the superior mesenteric artery (SMA) and bilateral renal arteries. Initially, to prevent the need to explant the liver, the distal SMA (with takeoff of the replaced common hepatic artery) was anastomosed to the splenic artery. The bulk of the tumor along with the bilateral kidneys was mobilized from the retroperitoneum, and the aorta and inferior vena cava (IVC) were cross-clamped above and below the tumor and divided. The two kidneys were dissected free of the tumor at the back-table and were auto-transplanted in a standard technique following the reconstruction of the aorta and IVC. The patient tolerated surgery well and a one-year postoperative follow-up did not show any sign of tumor recurrence. Although technically demanding, ex vivo resection and auto-transplantation of the involved organs can be introduced as a final option for the treatment of tumors that are un-resectable using standard surgical techniques. IntroductionGanglioneuromas (GNs) are rare, slow-growing benign tumors arising from the sympatho-adrenal neuroendocrine system (1,2). GNs typically occur in children and adolescents, with up to 60% of patients <20 years old at the time of diagnosis. Additionally, females are more likely to be affected than males (3). GNs are the benign ends of a wide spectrum of peripheral neuroblastic tumors, which also include neuroblastoma, ganglioneuroblastoma and ganglioneuroblastoma intermixed (2,4). GN can be diagnosed de novo in healthy patients or in specific cases result from spontaneous or chemo-or radiotherapy induced maturation of less-differentiated neuroblastic tumors (neuroblastoma and ganglioneuroblastoma) (1,5). In addition, certain studies have presented an association between GNs and specific familial diseases including neurofibromatosis type 2 and multiple endocrine neoplasia type 2 (6,7). While GNs can occur anywhere along the sympathetic nervous system, the two most common locations of occurrence are the posterior mediastinum and retroperitoneum (6). Retroperitoneal tumors may originate from the adrenal glands or extra-adrenal tissues (6). There are a limited number of studies reporting tumor occurrence in uncommon locations, including the tongue, bladder, uterus and skin (8-10).Although complete surgical excision is considered to be the treatment of choice in the management of these tumors, occasionally it can be challenging and in specific cases (such as when large tumors are involving the surrounding vital organs) it is not a feasible option. The current case report pre...

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Retroperitoneal Ganglioneuroma: A Case Report and Review of the Japanese Literature.

Cited by 47 publications

References 6 publications

Imaging of retroperitoneal ganglioneuroma

Imaging of retroperitoneal ganglioneuroma

Ganglioneuroma: A Rare Neural Crest Tumor

Ex vivo excision of retroperitoneal soft tissue tumors: A case report

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