Retroperitoneal extrarenal angiomyolipoma with early gastric carcinoma

Mogi, Yoshihiro; Takimoto, Rishu; Kura, Toshiro; Tamakawa, Mitsuharu; Sakamaki, Sumio; Niitsu, Yoshiro

doi:10.1007/s005350050049

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…However, all of these cases were associated with renal angiomyolipoma and TS. This case was not associated with malignant tumor, but Tang et al reported an angiomyolipoma case of appendix carcinoid and Mogi et al reported a case of gastric cancer [4,11]. Although the number of cases of primary angiomyolipoma of the spleen is extremely small, it is necessary to consider the malignant complications.…”

Section: Discussionmentioning

confidence: 90%

Surgical resection of extremely rare primary giant splenic angiomyolipoma: a case report

et al. 2021

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Background Angiomyolipoma is a benign mesenchymal tumor that develops commonly in the kidney and rarely in other organs. The involvement of the spleen in angiomyolipoma is extremely rare, and only one such case has been reported in the English literature. Case presentation A 27-year-old man presented with adenoid hyperplasia and bilateral palatal tonsillar hyperplasia. During the treatment for adenoid hyperplasia, a 15-cm tumor was detected in the spleen using abdominal ultrasonography and enhanced computed tomography. Partial resection of the spleen was successfully performed. A giant tumor of approximately 13 cm with a smooth surface was observed in the upper left quadrant of the abdomen. The tumor was confirmed to be continuous with the upper spleen, and there was no invasion of the other organs. The postoperative course was good, and the patient was discharged on the 7th postoperative day. The excised specimen was a smooth, extremely soft tumor measuring 123 × 120 × 82 mm. The cleaved surface of the tumor was reddish brown, and a distressing yellow color was observed. Pathological examination revealed a proliferation of mature adipocytes and an increase in the number of blood vessels of various sizes. Furthermore, spindle-shaped cell proliferation foci were visible between the adipocytes and the surrounding blood vessels. Profuse leakage of erythrocytes from the blood vessels, hemosiderin deposition, and small round cell infiltration were also noted. Immunostaining disclosed that the spindle-shaped cells were weakly positive for smooth muscle antibody and were identified as smooth muscle cells. The adipocytes and spindle cells were negative for HMB 45, Melan A, MDM, and CDK4. However, some parts of the cells were positive for estrogen and progesterone receptors. Besides, vascular endothelial cells were positive for CD31 and CD34 and negative for CD8. Based on these findings, the patient was diagnosed to have primary angiomyolipoma of the spleen. Conclusions We have reported the surgical treatment for an extremely rare case of giant splenic angiomyolipoma in a young man. Globally, this is the second report on this condition. We believe that partial splenic resection is a feasible option for the management of giant tumors.

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Section: Discussionmentioning

confidence: 90%

Surgical resection of extremely rare primary giant splenic angiomyolipoma: a case report

et al. 2021

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“…Angiomyolipomas (AMLs) are rare complex mesenchymal neoplasms typically arising within the kidney and are composed of mature adipose tissue, smooth muscle cells, and thick-walled blood vessels [22]. Renal AMLs account for 1% of renal lesions, occurring more commonly in women [2] with an overall incidence in the general population of 0.07–0.3% [25].…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Extrarenal Angiomyolipomas: An Evidence-Based Approach to a Rare Clinical Entity

Minja

Pellerin

Saviano

et al. 2012

Case Reports in Nephrology

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Extrarenal angiomyolipomas (ERAMLs) are rare tumors that present as incidentalomas upon imaging for other conditions. Retroperitoneal ERAMLs present a unique challenge from a diagnostic and treatment standpoint as they can mimic other benign and malignant retroperitoneal tumors. We present a case of a 39-year-old female with a 19.3 cm × 13.5 cm × 10.7 cm left extrarenal retroperitoneal mass. Histopathologic examination and HMB-45 staining revealed the mass to be a retroperitoneal ERAML. Our case report provides a comprehensive literature review and an evidence-based algorithm for taking care of patients with ERAMLs.

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“…Mogi et al [ 13 ] in 1998 reported a 41-year-old woman who 2 years earlier undergone surgery for type IIc early gastric cancer and who presented with back pain and fullness of her abdomen. She had CT scan and MRI scan of her abdomen and pelvis which revealed a massive fat tumour mass that had extended from the hepatic hilus to the retroperitoneum (in her right perinephric space as well as her perihepatic space).…”

Section: Literature Reviewmentioning

confidence: 99%

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

Venyo

2016

International Journal of Surgical Oncology

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Background. Extrarenal retroperitoneal angiomyolipomas are rare. Aim. To review the literature. Results. Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid tissue. Immunohistochemistry tends to be positive for HMB45, MART1, HHF35, calponin, NKI-C3, and CD117. The lesion is common in women. Treatment options have included the following: (a) radical surgical excision of the lesion with renal sparing surgery or radical nephrectomy in cases where malignant tumours could not be excluded and (b) selective embolization of the lesion alone or prior to surgical excision. One case of retroperitoneal angiomyolipoma was reported in a patient 15 years after undergoing radical nephrectomy for angiomyolipoma of kidney and two cases of distant metastases of angiomyolipoma have been reported following radical resection of the tumour. Conclusions. With the report of two cases of metastases ensuing surgical resection of the primary lesions there is need for academic pathologists to debate and review angiomyolipomas to decide whether to reclassify angiomyolipomas as slow-growing malignant tumours or whether the reported cases of metastases were de novo tumours or metastatic lesions.

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Retroperitoneal extrarenal angiomyolipoma with early gastric carcinoma

Cited by 11 publications

References 16 publications

Surgical resection of extremely rare primary giant splenic angiomyolipoma: a case report

Surgical resection of extremely rare primary giant splenic angiomyolipoma: a case report

Retroperitoneal Extrarenal Angiomyolipomas: An Evidence-Based Approach to a Rare Clinical Entity

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

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