Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update

Hitchcock, Kathryn; Amdur, Robert J.; Morris, Christopher G.; Werning, John W.; Dziegielewski, Peter T.; Mendenhall, William M.

doi:10.1016/j.amjoto.2014.10.005

Cited by 13 publications

(29 citation statements)

References 27 publications

(38 reference statements)

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“…Similar to our data, married patients have improved survival with several different types of cancer . Subsite survival variability is debated in the literature, with several studies showing conflicting survival results for the oral tongue subsite compared with other oral cavity subsites, but lip tumors consistently have an improved survival, whereas buccal mucosal tumors consistently have reduced survival …”

Section: Discussionsupporting

confidence: 86%

Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study

et al. 2016

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Section: Discussionsupporting

confidence: 86%

Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study

et al. 2016

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“…That process eliminated another 100 articles. Thus, at the end of the selection process, 15 studies remained for the final assessment 1,[9][10][11][12][13][14][15][16][17][18][19][20][21][22] . All 15 articles were retrospective case-control studies.…”

Section: Resultsmentioning

confidence: 99%

“…In the risk of bias assessment, most studies had a total score between 10 and 15 and were thus categorized as having a moderate risk of bias 1,[9][10][11][12][13][14][16][17][18][20][21][22] . Two studies presented a score of 9 and were thus classified as having a high risk of bias 15,19 .…”

Section: Eligibility and Quality Assessmentmentioning

confidence: 99%

A systematic review of therapeutic outcomes following treatment of squamous cell carcinoma of the retromolar trigone

Kim

2021

JKAOMS

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Squamous cell carcinoma (SCC) of the retromolar trigone (RMT) is a rare but potentially fatal disease that carries a poor prognosis due to its unique anatomic position. RMT SCCs tend to spread to vital nearby structures, including the tonsillar pillar, masticatory muscles, and underlying mandibular bone, even in their early stages, and aggressive treatment is often warranted. This systematic review appraises and qualitatively analyzes all available literature regarding the survival outcomes and prognosis of RMT SCC. Four databases were searched to identify all eligible articles published since January 1980. Of the 1,248 studies, a total of 15 studies representing 4,838 cases met the inclusion criteria. The evaluated patients had a high rate of advanced tumor stage (T3 or T4: 61.4%), lymph node metastasis (38.8%), and mandibular bone invasion (24%) at the time of diagnosis. Aggressive surgical treatments such as lip-splitting (92%), segmental mandibulectomy (61.1%), radical neck dissection (44.1%), and reconstruction using free flaps (49.5%) was undertaken for 92% of the pooled patient population. The mean rates for local, regional, and systemic recurrence were 23.40%, 8.40%, and 8.50%, respectively. The mean 5-year overall survival rate was 38.90%. Osteonecrosis was noted in 11.6% of the 328 patients who received radiotherapy. In conclusion, RMT SCC is generally associated with high recurrence, low survival, and high postoperative complication rates. Early diagnosis and aggressive treatment are thus warranted. However, significant methodological problems hamper current knowledge. Future studies of this topic that use randomized or cohort designs are thus needed.

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“…Hitchcock et al reported on 36 patients with retromolar trigone SCC treated at UF with curative intent RT between 1966 and 2013. 35 The 5-year local-regional control (LRC) rates were: stages I-III, 52%; and IV, 46%. When compared with 74 patients treated with surgery and PORT, patients treated curative intent RT had a significantly lower likelihood of cure (p = 0.041).…”

Section: Discussionmentioning

confidence: 99%

Current Role of Radiotherapy in the Management of Oral Cavity Squamous Cell Carcinoma

Mendenhall

Holtzman

Dagan

et al. 2020

Craniomaxillofacial Trauma & Reconstruction

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Study Design: Literature review. Objective: To review the current role of radiotherapy (RT) in the management of oral cavity squamous cell carcinoma (SCC). Methods: Review of selected literature. Results: T1-T2N0 SCCs may be treated with either RT alone or surgery with a high likelihood of cure. The pendulum swung toward surgery with postoperative RT (PORT) added depending on the pathological findings in the mid 1980s. Patients with positive margins, extranodal extension (ENE), and/or 4 or more positive nodes receive concomitant chemotherapy (POCRT). Patients with T3-T4 and/or positive regional nodes are treated with surgery and PORT alone or POCRT. The likelihood of cure is moderate to low depending on extent of disease. The likelihood of major complications ranges from 10% to 30% depending on the method of reconstruction and the aggressiveness of postoperative PORT/POCRT. Patients with very advanced disease are treated with palliative RT, chemotherapy, or supportive care. Conclusions: The role of RT in the management of oral cavity SCC is primarily in the postoperative setting with palliative RT being reserved for those with very advanced disease where the likelihood of cure is remote.

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Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update

Cited by 13 publications

References 27 publications

Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study

Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study

A systematic review of therapeutic outcomes following treatment of squamous cell carcinoma of the retromolar trigone

Current Role of Radiotherapy in the Management of Oral Cavity Squamous Cell Carcinoma

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