Retromer localizes to autophagosomes during HCV
replication

Yin, Peiqi; Hong, Zhi; Zhang, Leiliang; Ke, Youyang

doi:10.1007/s12250-016-3914-2

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Similarly, hepatitis C virus (HCV) diverts retromer and its cargo, CI-MPR, to its replication site and uses them for its replication; silencing of both retromer and CI-MPR inhibits and reduces HCV replication, respectively [ 119 ]. Interaction of the retromer with autophagosome also promotes HCV replication [ 120 ], but further work is needed to establish how HCV uses the advantage of this interaction.…”

Section: Retromer and Invading Pathogensmentioning

confidence: 99%

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

Abubakar

Zheng

Olsson

et al. 2017

IJMS

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Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.

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Section: Retromer and Invading Pathogensmentioning

confidence: 99%

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

Abubakar

Zheng

Olsson

et al. 2017

IJMS

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“…Given that the CIMPR is necessary for trafficking lysosomal hydrolases to lysosomes (via endosomes) and that retromer regulates the endosome-to-Golgi retrieval of the CIMPR, it seems likely that loss of retromer is impacting on CIMPR localization, altering lysosome function which is then affecting virus replication. In the process of HCV replication, retromers located in autophagosomes, indicating that retromers may also regulate the replication of virus through autophagy ( Yin et al, 2017 ).…”

Section: The Roles For Retromer In the Life Cycle Of Virusmentioning

confidence: 99%

The emerging roles of retromer and sorting nexins in the life cycle of viruses

Ping

Zhang

et al. 2022

Virologica Sinica

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“…ATG5, ATG7, and ATG13 are the critical regulators of the autophagy pathways [5]. Moreover, adrenoceptor β2 (ADRB2), activating molecules in Beclin 1-regulated autophagy protein 1 (AMBRA1), C-type lectin domain containing 16A (CLEC16A), late endosomal/lysosomal adaptor, MAPK and mTOR activator 3 (LAMTOR3), optineurin (OPTN), and vacuolar protein sorting associated protein 26A (VPS26A) were also reported to have critical roles in autophagy [32][33][34][35][36][37]. Interestingly, the target genes were attenuated in stable shKDM3B HCT116 cells (Fig 2C).…”

Section: Kdm3b Regulates the Transcription Of Autophagy-related Genesmentioning

confidence: 99%

Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes

Jung

Seo

2020

PLoS ONE

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Autophagy, a self-degradative physiological process, is critical for homeostasis maintenance and energy source balancing in response to various stresses, including nutrient deprivation. It is a highly conserved catabolic process in eukaryotes and is indispensable for cell survival as it involves degradation of unessential or excessive components and their subsequent recycling as building blocks for the synthesis of necessary molecules. Although the dysregulation of autophagy has been reported to broadly contribute to various diseases, including cancers and neurodegenerative diseases, the molecular mechanisms underlying the epigenetic regulation of autophagy are poorly elucidated. Here, we report that the level of lysine demethylase 3B (KDM3B) increases in nutrient-deprived HCT116 cells, a colorectal carcinoma cell line, resulting in transcriptional activation of the autophagy-inducing genes. KDM3B was found to enhance the transcription by demethylating H3K9me2 on the promoter of these genes. Furthermore, we observed that the depletion of KDM3B inhibited the autophagic flux in HCT116 cells. Collectively, these data suggested the critical role of KDM3B in the regulation of autophagy-related genes via H3K9me2 demethylation and induction of autophagy in nutrient-starved HCT116 cells.

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Retromer localizes to autophagosomes during HCV replication

Cited by 5 publications

References 13 publications

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

The emerging roles of retromer and sorting nexins in the life cycle of viruses

Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes

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