Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma
Priya Chaudhary,
Howard Lockwood,
Cheri Stowell
et al.
Abstract:Purpose
To determine if structurally intact, retrolaminar optic nerve (RON) axons are demyelinated in nonhuman primate (NHP) experimental glaucoma (EG).
Methods
Unilateral EG NHPs (
n
= 3) were perfusion fixed, EG and control eyes were enucleated, and foveal Bruch's membrane opening (FoBMO) 30° sectoral axon counts were estimated. Optic nerve heads were trephined; serial vibratome sections (VSs) were imaged and colocalized to a fundus photogra… Show more
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