Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse

Makani, Sachin; Lutzu, Stefano; Lituma, Pablo J.; Hunt, David; Castillo, Pablo E.

doi:10.1523/eneuro.0450-20.2021

Cited by 2 publications

(1 citation statement)

References 70 publications

(105 reference statements)

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“…In addition, most previous research suggests that postsynaptic depolarization is not necessary for MF synapse LTP induction, although under certain conditions, such depolarization could still exert influence over presynaptic physiology ( Castillo et al, 2012 ; Makani et al, 2021 ; Vandael et al, 2021 ). This implies that synchronous activation of pre- and postsynaptic neurons is not necessarily a prerequisite for this form of LTP, suggesting that MF synapse LTP is not Hebbian in nature.…”

Section: The Mossy Fibers Pathway Cyclic Adenosine Mono-phosphate And...mentioning

confidence: 99%

cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal

Shahoha

Cohen

Ben-Simon

et al. 2022

Front. Synaptic Neurosci.

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Cyclic adenosine monophosphate (cAMP) is a crucial second messenger involved in both pre- and postsynaptic plasticity in many neuronal types across species. In the hippocampal mossy fiber (MF) synapse, cAMP mediates presynaptic long-term potentiation and depression. The main cAMP-dependent signaling pathway linked to MF synaptic plasticity acts via the activation of the protein kinase A (PKA) molecular cascade. Accordingly, various downstream putative synaptic PKA target proteins have been linked to cAMP-dependent MF synaptic plasticity, such as synapsin, rabphilin, synaptotagmin-12, RIM1a, tomosyn, and P/Q-type calcium channels. Regulating the expression of some of these proteins alters synaptic release probability and calcium channel clustering, resulting in short- and long-term changes to synaptic efficacy. However, despite decades of research, the exact molecular mechanisms by which cAMP and PKA exert their influences in MF terminals remain largely unknown. Here, we review current knowledge of different cAMP catalysts and potential downstream PKA-dependent molecular cascades, in addition to non-canonical cAMP-dependent but PKA-independent cascades, which might serve as alternative, compensatory or competing pathways to the canonical PKA cascade. Since several other central synapses share a similar form of presynaptic plasticity with the MF, a better description of the molecular mechanisms governing MF plasticity could be key to understanding the relationship between the transcriptional and computational levels across brain regions.

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Section: The Mossy Fibers Pathway Cyclic Adenosine Mono-phosphate And...mentioning

confidence: 99%

cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal

Shahoha

Cohen

Ben-Simon

et al. 2022

Front. Synaptic Neurosci.

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Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

Vandael,

Jonas

2024

Science

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The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.

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Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse

Abstract: Retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 pyramidal cell synapse

Cited by 2 publications

References 70 publications

cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal

cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal

Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

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