Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond

Richter, Andreas; Nägele, Thomas; Grimm, Bernhard; Kaufmann, Kerstin; Schroda, Michael; Leister, Dario; Kleine, Tatjana

doi:10.1016/j.xplc.2022.100511

Cited by 44 publications

(49 citation statements)

References 179 publications

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“…BBX16 has previously been implicated in retrograde signaling (Veciana et al ., 2022), and we suspected that BBX14 might also be a component of the GUN1-GLK1 module. The gun1 mutant is special in that – unlike all the other gun mutants – it also shows the gun phenotype under LIN conditions (summarized in (Richter et al ., 2023). To find out whether LIN-mediated repression of BBX14 is also dependent on GUN1, BBX14 mRNA expression was evaluated in 4-day-old Col-0 and gun1-102 seedlings grown on MS in the absence or presence of LIN.…”

Section: Resultsmentioning

confidence: 99%

“…Although the quest for genomes uncoupled (gun) mutants (i.e. seedlings that continue to express PhANGs even though plastid development has been blocked by NF or LIN) began 30 years ago, the mechanisms underlying this phenotype have yet to be fully clarified, and the number of known gun mutants now stands at less than ten (Richter et al, 2023). BBX14 (COL6), a member of clade III, attracted our attention because it was found together with GLK1 and GLK2 in a core module required for the nuclear retrograde response to altered organellar gene expression .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arabidopsis thalianaBBX14 is a target of GLK1 and involved in high-light acclimation, photomorphogenesis and GUN-type retrograde signaling

Atanasov¹,

Schumacher

Muiño

et al. 2023

Preprint

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SUMMARYDevelopment of photosynthetically competent seedlings requires both light and retrograde biogenic signaling pathways. The transcription factor GLK1 functions at the interface between these pathways, and receives input from the biogenic-signaling integrator GUN1. BBX14 was previously identified, together with GLK1, in a core module that mediates the response to high light levels and biogenic signaling. To gain insight into the function of BBX14, we generatedBBX14overexpressors and CRISPR/Cas-mediatedbbx14mutant plants, conducted high-light, RT-qPCR and ChIP-Seq experiments, measured photosynthetic parameters, chlorophyll contents and growth rates, and analyzed alterations in transcriptomics. We found that, although overexpression of BBX14 is deleterious under normal growth conditions, BBX14 is needed to acclimate plants to high light stress.BBX14is a direct target of GLK1, and RNA-Seq analysis suggests that BBX14 is involved in the circadian clock. Knockout ofBBX14results in a long-hypocotyl phenotype that depends on a retrograde signal, andBBX14expression during biogenic signaling requires GUN1. Finally, we clarify the role of BBX14 in GUN-type biogenic signaling. We conclude that BBX14 is an integrator of photomorphogenetic and biogenic signals, and suggest that BBX14 is a nuclear target of retrograde signals downstream of the GUN1/GLK1 module.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arabidopsis thalianaBBX14 is a target of GLK1 and involved in high-light acclimation, photomorphogenesis and GUN-type retrograde signaling

Atanasov¹,

Schumacher

Muiño

et al. 2023

Preprint

Self Cite

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“…The latest finding showed that this accumulation in the chloroplast substantially improves ROS detoxification activity throughout the cell (Richter et al, 2023). Heme, a probable RS, being hydrophobic, might be exported through cellular membranes or through a specific translocator called tryptophan-rich sensory protein (TSPO; Nagahatenna et al, 2016).…”

Section: Tpb-mediated Stress Resistancementioning

confidence: 99%

“…Since then, considerable information has been generated on various aspects of the RSG. Researchers have attempted to elucidate the types and nature of the retrograde signals originated by chloroplasts, the mode of inter‐compartment transmission of the signals and their possible physiological implications on plant metabolism (Crawford et al, 2018; Leister, 2012; Richter et al, 2023). This review discusses the current status of RSG from chloroplast to nucleus with emphasis on the types of retrograde signals, the putative mechanisms of their functioning, and their possible involvement in modulating plant stress adaptation.…”

Section: Introductionmentioning

confidence: 99%

Components and processes involved in retrograde signaling from chloroplast to nucleus

Agrawal,

Singh,

Tripathi

2023

Physiologia Plantarum

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Retrograde signaling conceptually means the transfer of signals from semi‐autonomous cell organelles to the nucleus to modulate nuclear gene expression. A generalized explanation is that chloroplasts are highly sensitive to environmental stimuli and quickly generate signaling molecules (retrograde signals) and transport them to the nucleus through the cytosol to reprogram nuclear gene expression for cellular/metabolic adjustments to cope with environmental fluctuations. During the past decade, substantial advancements have been made in the area of retrograde signaling, including information on putative retrograde signals. Researchers have also proposed possible mechanisms for generating retrograde signals and their transmission. However, the exact mechanisms and processes responsible for transmitting retrograde signaling from the chloroplast to the nucleus remain elusive, demanding substantial attention. This review highlights strategies employed to detect retrograde signals, their possible modes of signaling to the nucleus, and their implications for cellular processes during stress conditions. The present review also summarizes the role of ROS‐mediated retrograde signaling in plastid‐nucleus communication and its functional significance in co‐coordinating the physiological profile of plant cells.

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Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module

Sohail,

Noor,

et al. 2024

Funct Integr Genomics

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Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond

Cited by 44 publications

References 179 publications

Arabidopsis thalianaBBX14 is a target of GLK1 and involved in high-light acclimation, photomorphogenesis and GUN-type retrograde signaling

Arabidopsis thalianaBBX14 is a target of GLK1 and involved in high-light acclimation, photomorphogenesis and GUN-type retrograde signaling

Components and processes involved in retrograde signaling from chloroplast to nucleus

Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module

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