Retrograde ejaculation associated spontaneous sperm cystolithiasis in four rhesus macaques (Macaca mulatta)

Gumber, Sanjeev; Courtney, Cynthia L.; Strait, Karen; Sharma, Prachi; Freebersyser, Julie E.; Crane, Maria M.

doi:10.1016/j.etp.2013.05.003

Cited by 5 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cystolithiasis was rare, with most cases attributed to retrograde ejaculation in male rhesus macaques. 29 Tumors of the kidney and urinary bladder were uncommon, with 30 and 4 cases diagnosed, respectively. Lymphoma was the most common renal tumor.…”

Section: Discussionmentioning

confidence: 99%

Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers

et al. 2020

Self Cite

View full text Add to dashboard Cite

Given their genetic and anatomic similarities to humans, nonhuman primates (NHPs) may serve as animal models for urogenital diseases of humans. The purpose of this study was to examine the frequency of spontaneous urogenital lesions occurring over a 30-year period at the Yerkes and Southwest National Primate Research Centers and to compare and contrast lesions occurring in Old World versus New World primates. Lesions occurring in the chimpanzee ( Pan troglodytes), baboon ( Papio spp.), rhesus macaque ( Macaca mulatta), cynomolgus macaque ( Macaca fascicularis), pig-tailed macaque ( Macaca nemestrina), sooty mangabey ( Cercocebus atys), common marmoset ( Callithrix jacchus), cotton-top tamarin ( Sanguinus oedipus), and squirrel monkey ( Saimiri sciureus) are discussed. The most common lesions of the kidney were medullary amyloidosis, renal cysts, renal tubular degeneration, glomerulonephritis or glomerulopathy, nephritis, nephrocalcinosis, pyelonephritis, and hydronephrosis. Specific causes of renal tubular disease included pigmentary nephrosis and tubular lipidosis. Renal tumors, including renal adenoma and carcinoma, lymphoma, and nephroblastoma, were infrequent diagnoses in all species. Endometriosis was the most frequently diagnosed lesion of the female genital tract. Of the animals examined in this study, it was most frequent in Old World primates. Leiomyoma was the most common uterine tumor. Granulosa cell tumor was the most frequently observed neoplasm of the ovaries, followed by teratoma. Of animals included in the study, most ovarian tumors occurred in baboons. Neoplasms of the male reproductive tract included interstitial cell tumor, seminoma, penile squamous cell carcinoma, penile papilloma, and histiocytoma. In New World monkeys, renal lesions were reported more frequently than genital lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Comments: Concretions, calcified concretions or mineral in the testis, seminal vesicles, prostate and distal urinary tract are typically composed of calcium carbonate 11 , 425 , 433 , 434 , 435 , 436 , 437 . Semen calculi have been reported in prostatic and penile urethra of macaques 438 , 439 , 440 . Retrograde sperm ejaculation due to repeated electro-ejaculation causes trapping of semen in the posterior urethra and back flow into urinary bladder causing obstruction and can result in corpora amylacea 438 , 439 , however the observation is commonly observed in monkeys as a spontaneous change, particularly within the seminal vesicles.…”

Section: Reproductive System – Malementioning

confidence: 99%

“…Comments: In macaques, sperm reflux can occur spontaneously or associated with routine trans-rectal electroejaculation which induces a lack of synchronous flow potentially due to asynchronous stimulation of nerve tracts 438 , 439 . Sperm reflex when occurring as a spontaneous finding in macaques without any associated inflammatory or degenerative changes, does not need to be diagnosed routinely.…”

Section: Reproductive System – Malementioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (<i>M. fascicularis</i>)

et al. 2021

View full text Add to dashboard Cite

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the nonhuman primate used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

show abstract