Retrochiasmal Visual Field Defects From Multiple Sclerosis

Boldt, Henry A.; Haerer, Armin F.; Tourtellotte, Wallace W.; Henderson, J. Gordon; DeJong, Russell N.

doi:10.1001/archneur.1963.00460050115013

Cited by 13 publications

(4 citation statements)

References 10 publications

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“…In this case, there was a typical plaque in the contralateral primary visual area on MRI. Similarly, Boldt et al, in a large study of probable MS inpatients 20 , found homonymous hemianopsia in only 2.2% in the acute phase. Furthermore, in a retrospectively study of homonymous hemianopsia, involving 904 cases, 13 (1.4%) had multiple sclerosis as the etiologic cause 21 .…”

Section: Discussionmentioning

confidence: 79%

Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

Castro

Damasceno

et al. 2013

Arq. Neuro-Psiquiatr.

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ObjectiveIt was to investigate visual field (VF) abnormalities in a group of multiple sclerosis (MS) patients in the remission phase and the presence of magnetic resonance imaging (MRI) lesions in the optic radiations.MethodsVF was assessed in 60 participants (age range 20-51 years): 35 relapsing-remitting MS patients [20 optic neuritis (+), 15 optic neuritis (-)] and 25 controls. MRI (3-Tesla) was obtained in all patients.ResultsVisual parameters were abnormal in MS patients as compared to controls. The majority of VF defects were diffuse. All patients except one had posterior visual pathways lesions. No significant difference in lesion number, length and distribution was noted between patients with and without history of optic neuritis. One patient presented homonymous hemianopsia.ConclusionPosterior visual pathway abnormalities were found in most MS patients despite history of previous optic neuritis.

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Section: Discussionmentioning

confidence: 79%

Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

Castro

Damasceno

et al. 2013

Arq. Neuro-Psiquiatr.

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“…The frequency of homonymous visual field defects in MS has been reported to be 1% in Kahana's study, 43 1.3% in Hawkins' study, 44 3.5% in Boldt's study, 45 respectively. Tsuda et al 10 stated that homonymous hemianopia was detected in 2.5%, and completely resolved after corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 93%

Ocular Manifestations in Korean Patients with Multiple Sclerosis

Shin

Cheon

Hwang

et al. 2008

Neuro-Ophthalmology

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Objective: The overall influence of race on ocular manifestations in multiple sclerosis (MS) is unknown. Methods: This study reviewed ocular manifestations in Korean MS patients from 1996 to 2004. Results: Of the 121 patients, 62 (51%) showed ocular manifestations that comprised optic neuritis (ON) in 52 (42.9%), ocular motor deficits in 11 (9.1%), and visual field defects in 2 (1.7%). Of the 27 patients (45 eyes) with ON whose medical records were available for results of the ophthalmologic tests, 19 patients (70%) experienced painless visual loss and 8 eyes (17.8%) showed severe disc edema. Twenty-nine of 37 patients (78.4%) with isolated ON as an initial manifestation showed normal brain MRI and twenty-seven (73%) negative oligoclonal band (OCB). Of the ocular motor findings, unilateral internuclear ophthalmoplegia (6 patients) was the most common. Conclusions: Korean MS patients showed lower frequencies of ON and ocular motor deficits than Caucasian and Japanese patients. The known risk factors associated with increased risk of developing MS in several western studies did not apply to Korean ON. Our study suggests that ocular manifestations of MS may differ among the races.

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“…Symptomatic retrochiasmal lesions of the visual pathways, resulting in homonymous visual field defects (HVFD), have been reported since 1890 [4]. However, there are only three published case series, which report five, eight and 18 cases of HVFD in multiple sclerosis respectively [5][6][7]. All other publications deal with single case reports.…”

Section: Introductionmentioning

confidence: 99%

“…All other publications deal with single case reports. The frequency of HVFD in multiple sclerosis has been estimated at between 1.3% and 3.5% [5,[8][9][10][11]. Paradoxically, despite the low frequency of HVFD in multiple sclerosis, MRI and autopsy studies have shown that the retrochiasmal pathways are frequently affected by demyelinating lesions in multiple sclerosis (30-90%), with the periventricular area being the most common location of demyelinating lesions [8,10].…”

Section: Introductionmentioning

confidence: 99%

Homonymous visual field defects in patients with multiple sclerosis: results of computerised perimetry and optical coherence tomography

Schmutz

Borruat

2020

Swiss Med Wkly

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AIMS OF THE STUDY: Visual dysfunction is frequent in multiple sclerosis, usually resulting from retrobulbar optic neuritis or papillitis. Less frequently, demyelinating lesions can affect the retrochiasmal pathways. There are few reports of homonymous visual field defects (HVFD) in multiple sclerosis and little is known about their evolution. The purpose of this study was to better define both the clinical profile and the evolution of HVFD in patients with multiple sclerosis. METHODS:We performed a retrospective study of all multiple sclerosis patients who presented HVFD and were examined by automated static perimetry. A subset of patients benefited from macular assessment with optical coherence tomography (OCT). We also reviewed the worldwide literature on the subject. RESULTS: Twenty patients were retrieved from the neuroophthalmology database of the Hôpital Ophtalmique Jules-Gonin. There were 11 women and 9 men, and their average age was 35 ± 11 years. The relapsing-remitting form of multiple sclerosis was most common (18/20; 90%), the primary progressive form (1/20; 5%) and the secondary progressive form (1/20; 5%) were rare. HVFD were the presenting symptom of multiple sclerosis in seven patients (35%). The recovery was complete in 12/20 patients (60%), and the median time to recovery was 10 weeks (2-13 weeks). An incomplete recovery was found in 5/20 subjects (25%) and no recovery occurred in 3/20 subjects (15%). Magnetic resonance imaging disclosed a definite lesion explaining the HVFD in 7/11 patients: five within the optic radiations (71.4%), one within the optic tract (14.3%) and one within the lateral geniculate nucleus (14.3%). Our results were comparable to those compiled from our literature search (29 publications, totalling 70 cases). A recurrent episode of HVFD occurred in three patients (15%). OCT was performed in 10/20 patients. Retinal ganglion cell layer thickness was assessed and revealed a homonymous thinning in three patients, diffuse unilateral or bilateral thinning (resulting from previous episodes of optic neuritis) in six patients, and normal retinal ganglion cell layer thickness in one patient. CONCLUSION: HVFD in multiple sclerosis are found mostly in young patients with relapsing-remitting multiple sclerosis, which is consistent with the epidemiology of multiple sclerosis. HVFD can be the first manifestation of multiple sclerosis and have a relatively good prognosis. Like optic neuritis, HVFD can recur. The incidence of HVFD in multiple sclerosis is unknown, as it is probably underdiagnosed. Systematic automated static perimetry and OCT could help to determine the true incidence of HVFD in multiple sclerosis.

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Retrochiasmal Visual Field Defects From Multiple Sclerosis

Cited by 13 publications

References 10 publications

Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

Ocular Manifestations in Korean Patients with Multiple Sclerosis

Homonymous visual field defects in patients with multiple sclerosis: results of computerised perimetry and optical coherence tomography

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