Replacement 32All authors have made a substantial contribution to this work, have read and concur with 33 the content of the manuscript. 34 This work has not been submitted for publication elsewhere, but was presented as a poster 35 at the ISTA conference 2011. The CFR-PEEK cup was observed to produce the closest bone strain to the intact hip in the main 50 load path, the superior peri-acetabular cortex (+12% on average, R 2 =0.84), in comparison to CoCr 51 (+40%, R 2 =0.91) and UHWMPE cups (-26%, R 2 =0.94). Clinical observations have indicated that 52 increased periacetabular cortex loading may result in reduced polar cancellous bone loading, leading 53 to longer term losses in periprosthetic bone mineral density. This study provides experimental 54 evidence to verify previous computational studies, indicating that cups produced using materials 55 with stiffness closer to cortical bone recreate physiological cortical bone strains more closely and 56 could, therefore, potentially promote less adverse bone adaptation than stiffer press-fitted implants 57 in current use. 58 59 60 4