Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report

Hernández-Monjaraz, Beatriz; Santiago‐Osorio, Edelmiro; Ledesma‐Martínez, Edgar; Alcauter-Zavala, Andrés; Mendoza-Núñez, Vı́ctor Manuel

doi:10.1177/0300060518773244

Cited by 44 publications

(58 citation statements)

References 43 publications

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“…The use of dental pulp stem cells (DPSC) has shown some potential towards regenerating the periodontium. Interestingly, 3 independent case reports described an improvement of the clinical parameters of periodontitis by the implantation of DPSC with collagen scaffold 41,42) or β-TCP 43) . Although the results of several pre-clinical animal studies and case reports were promising, human randomized trials are required to evaluate the efficacy of those procedures in regenerating true periodontal defects.…”

Section: Periodontal (Pdl) Derived Cellsmentioning

confidence: 99%

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Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies

et al. 2019

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The aim of the systematic review was to analyze the use of mesenchymal stem cells (MSC) and biomaterial for periodontal regeneration from preclinical animal models and human. Electronic databases were searched and additional hand-search in leading journals was performed. The research strategy was achieved according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The including criteria were as follows: MSC, biomaterial, in vivo studies, with histologic and radiologic analysis and written in English. The risk of bias was assessed for individual studies. A total of 50 articles were selected and investigated in the systematic review. These results indicate that MSC and scaffold provide beneficial effects on periodontal regeneration, with no adverse effects of such interventions. Future studies need to identify the suitable association of MSC and biomaterial and to characterize the type of new cementum and the organization of the periodontal ligament fiber regeneration.

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Section: Periodontal (Pdl) Derived Cellsmentioning

confidence: 99%

“…To date, current data indicate that MSC associated with suitable scaffolds may provide beneficial effects on periodontal regeneration in preclinical animal models and humans. In particular interest, the human studies suggest that there are no adverse effects of such interventions 40,42) .…”

Section: The Others Stem Cells Usedmentioning

confidence: 99%

Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies

et al. 2019

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“…Periodontal regeneration was investigated in human clinical studies using PDLSCs, DPSCs, and BMMSCs. DPSCs were observed in two case reports [105,106] and three case series [107][108][109] . One of the case reports provided positive results for allogenic transplantation of DPSCs [106] .…”

Section: Human Studiesmentioning

confidence: 99%

“…DPSCs were observed in two case reports [105,106] and three case series [107][108][109] . One of the case reports provided positive results for allogenic transplantation of DPSCs [106] . In parallel, some initial reports in humans demonstrated the clinical and radiographic efficacy of dental pulp micrografts in post-extraction alveolar defects [110,111] .…”

Section: Human Studiesmentioning

confidence: 99%

Stem cells and periodontal regeneration: present and future

Citterio¹,

Gualini²,

Fierravanti³

et al. 2020

Plast Aesthet Res

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The ultimate goal of periodontal regeneration is to restore the damaged alveolar bone proper, root cementum, and periodontal ligament with collagen fibers inserted into the root surface. The search for new regenerative strategies is a challenging field of periodontal research, and tissue engineering, using stem cells, has recently been shown as a promising approach. This paper aims at reviewing the current available literature on the use of stem cells for the treatment of periodontitis. Up to now, different mesenchymal stem cells (MSCs) have shown potential for periodontal regeneration in animal studies. The most investigated MSCs for periodontal regeneration are bone marrow MSCs (BMMSCs), periodontal ligament stem cells (PDLSCs), and dental pulp stem cells (DPSCs), which have shown very promising results in animal models. Few studies on humans are available but BMMSCs, PDLSCs, and DPSCs have been proven safe and effective. Clinical trials are sparse, but tend to support the efficacy of MSCs for periodontal regeneration. In the future, more human studies will be required to support the use of MSCs in daily clinical practice, especially in order to identify the best protocol to harvest, process, and graft MSCs. Future perspectives include trans-differentiation of somatic cells to generate induced pluripotent stem cells, homing procedures, the use of exogenous stem cells, and 3D-printed scaffolds.

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“…The progression of dental caries lesions needs time. Fluoride protects the teeth from dental caries by influencing the tooth structure [2]. Dental caries is usually performed using a tool called explorer that catches as it moves across a tooth with a cavity.…”

Section: Introductionmentioning

confidence: 99%

Photoemission Spectra of Sound Tooth and Those of Different Carious Stages

Marouf¹,

Khairallah²,

Awooda³

2019

EJB

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Fluorescence, absorption, and excitation spectroscopy have been widely utilised as probes to collect basic information about physical, chemical, and biological processes. In this study nitrogen laser (N 2) was used to induce emission in human teeth to distinguish between dental caries and sound teeth. Three samples of dental caries and one sample of sound teeth have been used to obtain fluorescence spectra illuminated with wavelengths of 337.1 nm, pulse energy 0.04 mJ and pulse time 100 nsec. The absorbance of dental caries and sound teeth was determined using UV-Vis spectrophotometer. The result showed an emission of broadband in the visible region from 363 nm to 627 nm; it provided an amount of information related to intrinsic fluorophores and allowed an accurate diagnosis by the use of the fluorescence intensity changes, it was observed significant decrease of the fluorescence signal intensity related to the carious stage in dental caries, while it was higher in the sound tooth spectrum indicates that the intensity is depending on the amount of decay. A definite diagnosis could be established based on the fluorescence intensity ratio. The future for laser induced fluorescence in diagnostic dentistry has been indicated as accurate and potentially applicable in a wide range in restorative dentistry, periodontology and endodontics.

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Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report

Cited by 44 publications

References 43 publications

Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies

Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies

Stem cells and periodontal regeneration: present and future

Photoemission Spectra of Sound Tooth and Those of Different Carious Stages

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