Retreatment with radiotherapy for painful bone metastases

Mithal, N.; Needham, P. R. G.; Hoskin, Peter

doi:10.1016/0360-3016(94)90396-4

Cited by 88 publications

(10 citation statements)

References 13 publications

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“…They can cause pain and affect weight-bearing areas and consequently have a significant impact on quality of life. The role of radiotherapy in the palliation of bone metastases is well supported in the literature, with reported response rates of around 70-90% [10,[12][13][14][15]. The pain relief is complete in nearly half of the responders [14,16].…”

Section: Radiotherapysupporting

confidence: 49%

“…If patients fail to respond to the first treatment, then they may respond to re-treatment. In a retrospective analysis of 105 consecutive patients, the overall response rate to initial treatment was 84% for pain relief, and at re-treatment was 87% [15]. A single dose of 6-10 Gy is generally thought to be as effective as fractionation [10,13,14], although this view is not supported by all studies [12].…”

Section: Radiotherapymentioning

confidence: 64%

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The Treatment of Distant Metastases in Head and Neck Cancer – Present and Future

Buckley

Ferlito

Shaha

et al. 2001

ORL

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At the present time the occurrence of distant metastases in patients with head and neck squamous cell carcinoma means that lifespan is measured in months. In most instances treatment is purely palliative. Isolated lung metastasis can be successfully removed with long-term disease control in selected patients. Radiotherapy can be useful for palliation of bone metastases and occasionally lung or brain metastases. Chemotherapy does not have a major impact at the present time except for the treatment of metastases from nasopharyngeal cancer. Palliative symptomatic care, along with appropriate pain control, is essential since pain management is very important in these patients. A significant change in the survival of patients with head and neck cancer is only likely to occur by the development of new approaches to treatment. Blocking tumor angiogenesis and treatment based on genetic abnormalities or cell surface receptors offer the two strategies that are most likely to be successful.

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Section: Radiotherapysupporting

confidence: 49%

Section: Radiotherapymentioning

confidence: 64%

The Treatment of Distant Metastases in Head and Neck Cancer – Present and Future

Buckley

Ferlito

Shaha

et al. 2001

ORL

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“…A similarly signifi cant diff erence was revealed in a meta-analysis including 4.085 patients with a 2.5-fold higher likelihood for a re-treatment [25]. Re-irradiation can be administered according to various single and fractionated regimens [26]. In a randomized trial authors reported complete response rates of 24-33% and overall response rates of 65-78% after re-irradiation with a single dose of 4.0 Gy [27].…”

Section: Dose Fractionation and Ef Cacy Of Palliative Radiation Therapymentioning

confidence: 85%

Radiation therapy for palliation of cancer-related chronic pain

Sztankay

2009

memo

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Percutaneous radiotherapy is highly eff ective as a part of an interdisciplinary approach in the treatment of cancer-related chronic pain. Overall response rates of 70-90% and complete pain relief rates of 40-50% have been reported in numerous retrospective and randomized clinical trials. Beside the analgesic eff ect, radiation therapy enables the restoration of bony structure and musculoskeletal function, improves patients' mobility and quality of life. Th e objective of this publication is to give a short review over the role and importance of radiation therapy in the palliative management of patients with cancer-associated pain.

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“…The overall response rate was 50% (7/14), and CR was achieved in only one patient (7%). The pain response outcomes in previous studies [5,[9][10][11][12][13][14][15][16][17][18][19][20] are shown in Table 5. The CR rates for reirradiation ranged from 11% to 100%, and the PR rates ranged from 31% to 78%.…”

Section: Discussionmentioning

confidence: 99%

Palliative Reirradiation for Painful Bone Metastases: Clinical Cases and Literature Review

et al. 2017

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Summary:Reirradiation to previously irradiated peripheral bone metastases for pain has been shown to be safe and effective, but no specific trial has been completed to define the indications for reirradiation of patients with recurrent symptoms of metastatic bone disease. Thus, we aimed to assess the effectiveness and prognostic factors of reirradiation for painful bone metastases. To do so, we reviewed the cases of 14 patients with painful bone metastases who had undergone reirradiation at our hospital. A favorable pain response after reirradiation was achieved in 50% (7/14) of the patients. An interval from initial radiotherapy > 6 months was a significant prognostic factor for pain response (p = 0.03). Performance status was correlated with pain response, with borderline significance (p = 0.06). No severe adverse events were reported. We conclude that reirradiation of painful bone metastases is effective in providing pain relief, especially for patients with a long interval from initial radiation and good performance status.

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Retreatment with radiotherapy for painful bone metastases

Cited by 88 publications

References 13 publications

The Treatment of Distant Metastases in Head and Neck Cancer – Present and Future

The Treatment of Distant Metastases in Head and Neck Cancer – Present and Future

Radiation therapy for palliation of cancer-related chronic pain

Palliative Reirradiation for Painful Bone Metastases: Clinical Cases and Literature Review

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