Retreatment of Ruptured Cerebral Aneurysms in Patients Randomized by Coiling or Clipping in the International Subarachnoid Aneurysm Trial (ISAT)

Abstract

Background and Purpose-Because the long-term security of endovascular treatments remains uncertain, a follow-up study of the patients treated in the International Subarachnoid Aneurysm Trial was performed to compare the frequency, timing, and consequences of aneurysm recurrence. Methods-Patient data were reclassified by actual treatment performed. Aneurysm and patient characteristics, including occlusion grades, time and type of retreatment, and clinical outcomes, were compared. The relationship between these variables and late retreatment as a surrogate for recurrence was analyzed by means of the Cox proportional hazards model. Results-Retreatment was performed in 191 of 1096 (17.4%) patients after primary endovascular coiling (EVT) and in 39 of 1012 patients (3.8%) after neurosurgical clipping. After EVT, 97 (8.8%) patients were retreated early and 94 (9.0%) late, 7 (0.6%) after rebleeding and 87 (8.3%) without. The mean time to late retreatment was 20.7 months. After neurosurgical clipping, 30 (2.9%) patients were retreated early and 9 (0.85%) late, 3 (0.3%) after rebleeding and 6 (0.6%) without. The mean time to late retreatment was 5.7 months. The hazard ratio (HR) for retreatment after EVT was 6.9 (95% CIϭ3.4 to 14.1) after adjustment for age (Pϭ0.001, HRϭ0.97, 95% CIϭ0.95 to 0.98), lumen size (Pϭ0.006, HRϭ1.1, 95% CIϭ1.03 to 1.18), and incomplete occlusion (PϽ0.001, HRϭ7.6, 95% CIϭ3.3 to 17.5). Conclusions-Late retreatment was 6.9 times more likely after EVT. Younger age, larger lumen size, and incomplete occlusion were risk factors for late retreatment after EVT. After neurosurgical clipping, retreatments were earlier; whereas EVT retreatments continued to be performed throughout the follow-up period. Short-term follow-up imaging is therefore insufficient to detect recurrences after EVT.

No advantage of time-of-flight magnetic resonance angiography at 3 Tesla compared to 1.5 Tesla in the follow-up after endovascular treatment of cerebral aneurysms

“…An aneurysm recurrence rate between 20% and 30% after endovascular treatment has been reported [3,4,14,15]. The re-treatment rate in the International Subarachnoid Aneurysm Trial (ISAT) study group was 17.4% [14].…”

“…The re-treatment rate in the International Subarachnoid Aneurysm Trial (ISAT) study group was 17.4% [14]. As currently no guideline exists proposing MRA as the followup method of the first choice, the gold standard in followup diagnostic imaging is still the intraarterial DSA, associated with an inherent small rate of permanent neurological deficit [16].…”

Survival Analysis of Risk Factors for Major Recurrence of Intracranial Aneurysms after Coiling

“…The main challenge lies in the fact that the definition of "recurrence" varies greatly in the literature. This variability generates a wide range of recurrence rates and results with considerable range in its association with multiple potential risk factors 5,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . We applied a strict definition of recurrence and major recurrence and analyzed the relationship between several clinical, anatomical and technical data as a surrogate of major recurrence using survival analysis.…”

Gigantska aneurizma unutrašnje karotidne arterije, mogućnosti liječenja u zavisnosti od operativnog rizika

“…Najznačajnija i najopasnija posljedica prisustva aneurizme na krvnim sudovima mozga je pucanje (ruptura) njenog zida i krvarenje [8,9]. Aneurizme se klasifikuju prema veličini i obliku.…”