Retransfusion of suctioned blood during cardiopulmonary bypass impairs hemostasis

Haan, J. de; Boonstra, Piet W.; Monnink, Shj; Ebels, Tjark; Oeveren, Willem van

doi:10.1016/0003-4975(95)00012-a

Cited by 156 publications

(130 citation statements)

References 18 publications

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“…Although this is recommended by several authors and manufacturers [6][7][8] cardiotomy suction blood to the cardiopulmonary bypass (CPB) circuit is usually the first step in blood conservation during cardiac surgery. Cardiotomy blood is highly inflammatory and associated with increased transfusion requirements and organ injury [9,10]. It can be processed either by washing with a CS [2] or by passing through a leukocyte depletion (LD) filter [8].…”

mentioning

confidence: 99%

Effects of Cell-Saving Devices and Filters on Transfusion in Cardiac Surgery: A Multicenter Randomized Study

Vermeijden

Klarenbosch

et al. 2015

The Annals of Thoracic Surgery

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mentioning

confidence: 99%

Effects of Cell-Saving Devices and Filters on Transfusion in Cardiac Surgery: A Multicenter Randomized Study

Vermeijden

Klarenbosch

et al. 2015

The Annals of Thoracic Surgery

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“…14 -16 Animal models of CPB have also confirmed the relationship of cardiotomy blood readministration to the density of small capillary and arteriolar dilatations at autopsy. 17 Because the quantity of cardiotomy blood collected during CPB may be considerable, 18,19 routinely discarding this blood in an effort to prevent microembolization may result in increased blood product requirements. As an alternative, up to 40% of cardiac teams regularly process cardiotomy blood with centrifugal washing.…”

mentioning

confidence: 99%

The Cardiotomy Trial

et al. 2007

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Background-Reinfusion of unprocessed cardiotomy blood during cardiac surgery can introduce particulate material into the cardiopulmonary bypass circuit, which may contribute to postoperative cognitive dysfunction. On the other hand, processing of this blood by centrifugation and filtration removes coagulation factors and may potentially contribute to coagulopathy. We sought to evaluate the effects of cardiotomy blood processing on blood product use and neurocognitive functioning after cardiac surgery. Methods and Results-Patients undergoing coronary and/or aortic valve surgery using cardiopulmonary bypass were randomized to receive unprocessed blood (control, nϭ134) or cardiotomy blood that had been processed by centrifugal washing and lipid filtration (treatment, nϭ132). Patients and treating physicians were blinded to treatment assignment. A strict transfusion protocol was followed. Blood transfusion data were analyzed using Poisson regression models. The treatment group received more intraoperative red blood cell transfusions (0.23Ϯ0.69 U versus 0.08Ϯ0.34 U, Pϭ0.004).Both red blood cell and nonred blood cell blood product use was greater in the treatment group and postoperative bleeding was greater in the treatment group. Patients were monitored intraoperatively by transcranial Doppler and they underwent neuropsychometric testing before surgery and at 5 days and 3 months after surgery. There was no difference in the incidence of postoperative cognitive dysfunction in the 2 groups (relative risk: 1.16, 95% CI: 0.86 to 1.57 at 5 days postoperatively; relative risk: 1.05, 95% CI: 0.58 to 1.90 at 3 months). There was no difference in the quality of life nor was there a difference in the number of emboli detected in the 2 groups. Conclusions-Contrary

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“…Grup 1'deki hastalarda, aspiratörden çekilen kanın ikinci rezervuara alınmasının kan hücreleri üzerinde travmayı azaltıcı ve hemostaz üzerine olumlu etkileri olduğu, bunun da sistemik enflamatuvar yanıtı azaltmada faydası olduğunu belirten çalışmalar vardır. [26][27][28] Çalışmamızda elde edilen sonuçlar bu verileri desteklememektedir.…”

Section: Tablo 2 Enflamatuvar Faktörlerin Her Iki Gruptaki Ameliyat unclassified

The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass

Çalışal¹

2013

Turk Gogus Kalp Dama

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Retransfusion of suctioned blood during cardiopulmonary bypass impairs hemostasis

Cited by 156 publications

References 18 publications

Effects of Cell-Saving Devices and Filters on Transfusion in Cardiac Surgery: A Multicenter Randomized Study

Effects of Cell-Saving Devices and Filters on Transfusion in Cardiac Surgery: A Multicenter Randomized Study

The Cardiotomy Trial

The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass

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