Retraction to: “Signaling pathways in tumor vasculogenic mimicry”

Paulis, Yvette W.J.; Soetekouw, Patricia M.M.B.; Verheul, H.; Tjan‐Heijnen, Vivianne C. G.

doi:10.1134/s000629791306014x

Cited by 1 publication

(4 citation statements)

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“…4 Several molecular mechanisms and signal transduction pathways participate in VM formation. 5,6,40 In vitro, we found that TP53INP1 knock-down was associated with the formation of channel-like structures in breast cancer cells. In addition, the expression of VE-cadherin, a hallmark of VM, was reduced in TP53INP1-overexpressing breast cancer cells.…”

Section: Discussionmentioning

confidence: 85%

“…VM can provide a blood supply for a malignant tumour, and it also provides a route for tumour cells to escape the primary lesion . Several molecular mechanisms and signal transduction pathways participate in VM formation …”

Section: Discussionmentioning

confidence: 99%

“…Vasculogenic mimicry (VM), a newly discovered blood supply model, is a vessel structure made of cancer cells and lacking endothelial cells . A hypoxic microenvironment not only leads to VM formation but also accelerates tumour metastasis, increasing the risk of resistance to chemotherapy in breast cancer . The expression of hypoxia‐inducible factor‐1α (HIF‐1α) has been reported to be associated with VM in many cancers types, including liver cancer, ovarian cancer, colorectal cancer and melanoma .…”

Section: Introductionmentioning

confidence: 99%

“…4 A hypoxic microenvironment not only leads to VM formation but also accelerates tumour metastasis, increasing the risk of resistance to chemotherapy in breast cancer. 5,6 The expression of hypoxia-inducible factor-1a (HIF-1a) has been reported to be associated with VM in many cancers types, including liver cancer, 7 ovarian cancer, 8 colorectal cancer 9 and melanoma. 10 These observations suggest a new idea for inhibiting VM formation in hypoxia.…”

mentioning

confidence: 99%

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TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer

Wang

Sun

Zhang

et al. 2018

J Cellular Molecular Medi

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Tumour protein p53‐inducible nuclear protein 1 (TP53INP1) is a tumour suppressor associated with malignant tumour metastasis. Vasculogenic mimicry (VM) is a new tumour vascular supply pattern that significantly influences tumour metastasis and contributes to a poor prognosis. However, the molecular mechanism of the relationship between TP53INP1 and breast cancer VM formation is unknown. Here, we explored the underlying mechanism by which TP53INP1 regulates VM formation in vitro and in vivo. High TP53INP1 expression was not only negatively correlated with a poor prognosis but also had a negative relationship with VE‐cadherin, HIF‐1α and Snail expression. TP53INP1 overexpression inhibited breast cancer invasion, migration, epithelial‐mesenchymal transition (EMT) and VM formation; conversely, TP53INP1 down‐regulation promoted these processes in vitro by functional experiments and Western blot analysis. We established a hypoxia model induced by CoCl2 and assessed the effects of TP53INP1 on hypoxia‐induced EMT and VM formation. In addition, we confirmed that a reactive oxygen species (ROS)‐mediated signalling pathway participated in TP53INP1‐mediated VM formation. Together, our results show that TP53INP1 inhibits hypoxia‐induced EMT and VM formation via the ROS/GSK‐3β/Snail pathway in breast cancer, which offers new insights into breast cancer clinical therapy.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%