Retraction to Chronic Inflammation: Accelerator of Biological Aging

Fougère, Bertrand; Boulanger, Éric; Nourhashémi, Fati; Guyonnet, Sophie; Cesari, Matteo

doi:10.1093/gerona/gly284

Cited by 45 publications

(58 citation statements)

References 93 publications

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“…14 Taken together, alleviation of systemic inflammation could in theory prevent and/or mitigate the development of certain age-associated chronic disorders, linked to 'inflammaging'. Although a pathogenic role of 'inflammaging' in the development of systemic disorders in aged humans is widely acknowledged, [1][2][3]15,16 the possibility that the responsible cytokines could originate in the skin has not yet been explored. Yet, because of its sheer size, the skin is worthy of consideration as a potential contributor to systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Topical applications of an emollient reduce circulating pro‐inflammatory cytokine levels in chronically aged humans: a pilot clinical study

Mauro

Dang

et al. 2019

Acad Dermatol Venereol

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Background While increased levels of circulating inflammatory cytokines in chronologically aged humans have been linked to the development of ageing‐associated chronic disorders (e.g., cardiovascular disease, type II diabetes, osteoporosis and Alzheimer's disease), approaches that reduce circulating cytokines are not yet available. In chronologically aged mice, we recently demonstrated that epidermal dysfunction largely accounts for age‐associated elevations in circulating cytokine levels, and that improving epidermal function reduced circulating cytokine levels. Objective We performed a pilot study to determine whether improving epidermal function reduces circulating pro‐inflammatory cytokine levels in aged humans. Methods Thirty‐three aged humans were topically treated twice‐daily for 30 days, with ≈ 3 mL of an emollient, previously shown to improve epidermal function, while untreated, aged humans and a cohort of young volunteers served as controls. Changes in epidermal function and levels of three key, age‐related, plasma cytokines (IL‐1β, IL‐6 and TNFα) were measured at baseline and after treatment, using Luminex 200™ system. Results We also found significantly higher baseline levels of IL‐1β, IL‐6 and TNFα in aged vs. young humans (P < 0.001), as previously reported. Topical applications of the barrier repair emollient significantly enhanced epidermal permeability barrier function (P < 0.01) and stratum corneum hydration (P < 0.05). In parallel, circulating levels of IL‐1β and IL‐6 normalized, while TNFα levels declined substantially. Conclusion The results of this preliminary study suggest that a larger clinical trial should be performed to confirm whether improving epidermal function also can reduce circulating pro‐inflammatory cytokine levels in aged humans, while also possibly attenuating the downstream development of chronic inflammatory disorders in the aged humans.

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Section: Discussionmentioning

confidence: 99%

Topical applications of an emollient reduce circulating pro‐inflammatory cytokine levels in chronically aged humans: a pilot clinical study

Mauro

Dang

et al. 2019

Acad Dermatol Venereol

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“…43 Bidirectional relationships have been postulated between frailty and several chronic diseases. In some cases, this may be due to shared pathophysiology (eg, cardiovascular and cerebrovascular disease), 44 and in other cases, frailty may be linked with chronic disease via functional impairment (eg, osteoporosis with fracture). Consequently, chronic diseases are likely to be important therapeutic targets for frailty.…”

Section: Frailty Interventionsmentioning

confidence: 99%

Differences in frailty in older men and women

Gordon

Hubbard

2019

Medical Journal of Australia

104

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Summary Frailty describes an individual's vulnerability to adverse health outcomes and is a useful construct that assists health professionals to understand the heterogeneity of the ageing population. While the pathophysiological pathways that lead to frailty are not well defined, an individual's sex appears to be a key factor influencing the ageing trajectory. Compared with age‐matched men, women tend to have poorer health status (ie, they are more frail) but longer life expectancy (ie, they are more resilient). It seems likely that a combination of biological, behavioural and social factors underpin this male–female health–survival paradox. Randomised controlled trial data for frailty interventions in older adults are emerging, with multicomponent programs incorporating exercise and nutrition‐based strategies showing promise. Pharmaceutical and other innovative therapeutic strategies for frailty are highly anticipated. Sex differences in the effectiveness of frailty interventions have not been addressed in the research literature to date. In the future, successful interventions may target many (if not all) biopsychosocial domains, with careful consideration of issues relevant to each sex.

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“…5 A decline in health with advancing age is partly attributable to increased inflammation and number of comorbidities, many of which may be irreversible. 6,7 Decline in nutritional status is a modifiable risk factor that directly affects the development of malnutrition which, in most cases, is amenable to intervention. [8][9][10] It is important to identify nutritional vulnerability among community-dwelling older adults, so that preventative or supportive strategies can be implemented when needed.…”

mentioning

confidence: 99%

Associations between nutrition risk status, body composition and physical performance among community‐dwelling older adults

Chatindiara

Williams

Sycamore

et al. 2019

Australian and New Zealand Journal of Public Health

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Objective: To investigate the associations between nutrition risk status, body composition and physical performance among community‐dwelling older New Zealanders. Methods: This cross‐sectional study enrolled 257 community‐dwelling older adults (median age 79 years). Assessments included the Mini Nutritional Assessment‐Short Form (MNA®‐SF) for nutrition risk; the Eating Assessment Tool‐10 for dysphagia risk; bioimpedance analysis for body composition (free fat mass (FFM) and percentage body fat) and gait speed for physical performance. A multiple logistics regression analysis was conducted, to determine factors associated with lower odds [OR (95% CI)] for nutrition risk. Results: Every yearly increase in age was associated with higher odds 1.09 (1.01–1.17) for nutrition risk. Additionally, nutrition risk was less likely to occur among participants of age <85 years 0.30 (0.11–0.79), with no dysphagia 0.29 (0.09–0.97) and those with a healthy gait speed 0.29 (0.09–0.97). Lower odds for nutrition risk were also found with increasing values of FFM index 0.51 (0.34–0.77), and percentage body fat 0.81 (0.72–0.90). Gait speed was positively correlated with FFM index (r=0.19 p<0.022), percentage body fat (r=0.23, p=0.006) and BMI (r=0.29, p<0.001). Conclusion: Among these participants, associations between nutrition risk, body composition and physical performance were found. Implications for public health: Routine screening of nutrition risk and/or physical performance among vulnerable older adults is key towards identifying those in need of assessment and dietary intervention. Alongside strategies to encourage physical activity, this may help to slow losses of FFM and protect physical performance.

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Retraction to Chronic Inflammation: Accelerator of Biological Aging

Cited by 45 publications

References 93 publications

Topical applications of an emollient reduce circulating pro‐inflammatory cytokine levels in chronically aged humans: a pilot clinical study

Topical applications of an emollient reduce circulating pro‐inflammatory cytokine levels in chronically aged humans: a pilot clinical study

Differences in frailty in older men and women

Associations between nutrition risk status, body composition and physical performance among community‐dwelling older adults

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