Retraction of “Flexible and Microporous Chitosan Hydrogel/Nano ZnO Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation”

Kumar, P.T. Sudheesh; Anilkumar, T. V.; Ramya, C.; Reshmi, P.; Unnikrishnan, Ambika Gopalakrishnan; Nair, Shantikumar V.; Jayakumar, R.

doi:10.1021/acsami.9b11759

Cited by 30 publications

(34 citation statements)

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“…as compared with S. aureus, which was due to the thicker peptidoglycan layer of S. aureus. A similar result was observed in the flexible and microporous ZnO-incorporated chitosan composite bandages [28]. The antibacterial activity of the CPMAZnO-4 film indicated that this film could be appropriate for effective wound healing.…”

Section: Antibacterial and Cytotoxicity Studiessupporting

confidence: 77%

Zinc Oxide–Incorporated Chitosan–Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material

Seeli

Das

Prabaharan

2023

JFB

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A novel type of porous films based on the ZnO-incorporated chitosan–poly(methacrylic acid) polyelectrolyte complex was developed as a wound healing material. The structure of porous films was established by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and energy dispersive X-ray (EDX) analysis. Scanning electron microscope (SEM) and porosity studies revealed that the pore size and porosity of the developed films increased with the increase in zinc oxide (ZnO) concentration. The porous films with maximum ZnO content exhibited improved water swelling degree (1400%), controlled biodegradation (12%) for 28 days, a porosity of 64%, and a tensile strength of 0.47 MPa. Moreover, these films presented antibacterial activity toward Staphylococcus aureus and Micrococcus sp. due to the existence of ZnO particles. Cytotoxicity studies demonstrated that the developed films had no cytotoxicity against the mouse mesenchymal stem (C3H10T1/2) cell line. These results reveal that ZnO-incorporated chitosan-poly(methacrylic acid) films could be used as an ideal material for wound healing application.

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Section: Antibacterial and Cytotoxicity Studiessupporting

confidence: 77%

Zinc Oxide–Incorporated Chitosan–Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material

Seeli

Das

Prabaharan

2023

JFB

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“…125 Due to the mentioned properties of CS, this material has been used clinically as a wound dressing in various forms such as hydrogels, membranes, films, scaffolds, and sponges. [126][127][128] Honey Honeybees (Apis mellifera, family: Apidae) collect nectar from the flowers and produce a sweet and natural product called honey. 129 In fact, honey is a water-soluble natural carbohydrate.…”

Section: Animal Origin Carbohydratesmentioning

confidence: 99%

Natural polymers in wound healing: From academic studies to commercial products

Tavakoli

Labbaf

Mirhaj

et al. 2023

J of Applied Polymer Sci

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Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that are widely used in wound healing. This is due to their biocompatibility and their chemical structural similarity to the extracellular matrix (ECM). Wound healing is a complex process and requires a multidisciplinary approach and appropriate treatment product to enable a full recovery. Chronic nonhealing wounds significantly caused the reduction. Currently, diabetic and nonhealing wounds are considered the unmet clinical need and a new effective treatment will benefit patients and the economy. This research was aimed to critically review both literature as well as industrial products that used carbohydrates and proteins in wound dressing for the treatment of the wound. The outcome was chitosan (CS), as a carbohydrate, has the most clinical application as it is readily available and affordable, and has shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr has not yet found clinical use when compared with CS.

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“…Ideal wound dressings should have excellent antibacterial activity and promote wound healing processes by reducing the incidence of inflammatory responses. 35,36 The zeta potential of the PIL-OHA-6 hydrogel was 53.55 mV (Fig. S8 †), indicating Paper Biomaterials Science that the hydrogel surface was positively charged, which would endow the hydrogel with antibacterial performance and promotion of cell crawling and proliferation.…”

Section: In Vitro Antibacterial Performance Of the Pil-oha Hydrogelsmentioning

confidence: 99%

Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic wounds under electrical stimulation

et al. 2022

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Retraction of “Flexible and Microporous Chitosan Hydrogel/Nano ZnO Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation”

Cited by 30 publications

References 0 publications

Zinc Oxide–Incorporated Chitosan–Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material

Zinc Oxide–Incorporated Chitosan–Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material

Natural polymers in wound healing: From academic studies to commercial products

Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic wounds under electrical stimulation

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